Inhibition of SUMOylation promotes remyelination and reduces IL-17 mediated autoimmune inflammation: Novel approach toward treatment of inflammatory CNS demyelinating disease

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

(2021) Steven P. Langston et al.   JOURNAL OF MEDICINAL CHEMISTRY

Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study

(2021) Peng Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

RORγt protein modifications and IL-17-mediated inflammation

(2021) Ritesh Kumar et al.   TRENDS IN IMMUNOLOGY

Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis

(2020) Andrew P. Robinson et al.   Scientific Reports

The Role of TH17 Cells in Multiple Sclerosis: Therapeutic Implications

(2020) Tobias Moser et al.   AUTOIMMUNITY REVIEWS

Anacardic acid induces IL-33 and promotes remyelination in CNS

(2020) Åsa Ljunggren-Rose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes

(2020) Cuicui Wang et al.   JCI Insight

Transcriptional control of myelination and remyelination

(2019) Elisabeth Sock et al.   GLIA

Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation

(2018) Benayahu Elbaz et al.   Cell Reports

Elucidating the transactivation domain of the pleiotropic transcription factor Myrf

(2018) Jin-ok Choi et al.   Scientific Reports

SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2

(2018) Amir Kumar Singh et al.   Nature Communications

Sumoylation of RORγt regulates TH17 differentiation and thymocyte development

(2018) Zhiheng He et al.   Nature Communications

Ubc9Is Required for Positive Selection and Late-Stage Maturation of Thymocytes

(2017) Aibo Wang et al.   JOURNAL OF IMMUNOLOGY

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

(2017) Xingyue He et al.   Nature Chemical Biology

Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons

(2017) Yousuf O. Ali et al.   Scientific Reports

Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model

(2017) Marina Yu Khodanovich et al.   Scientific Reports

The implication of SUMO in intrinsic and innate immunity

(2016) Zara Hannoun et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases

(2016) Sascha Rutz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A mouse model for testing remyelinating therapies

(2016) C. Brian Bai et al.   EXPERIMENTAL NEUROLOGY

Protein SUMOylation Is Required for Regulatory T Cell Expansion and Function

(2016) Xiao Ding et al.   Cell Reports

Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions

(2015) Dhavalkumar D. Patel et al.   IMMUNITY

Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

(2015) Adrien Decque et al.   NATURE IMMUNOLOGY

Global Reprogramming of Host SUMOylation during Influenza Virus Infection

(2015) Patricia Domingues et al.   Cell Reports

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

SUMO: A Multifaceted Modifier of Chromatin Structure and Function

(2013) Caelin Cubeñas-Potts et al.   DEVELOPMENTAL CELL

Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation

(2013) H. Neyret-Kahn et al.   GENOME RESEARCH

A regenerative approach to the treatment of multiple sclerosis

(2013) Vishal A. Deshmukh et al.   NATURE

Interplay between viruses and host sumoylation pathways

(2013) Roger D. Everett et al.   NATURE REVIEWS MICROBIOLOGY

Effect of Leukemia Inhibitory Factor on the Myelinogenic Ability of Schwann-Like Cells Induced from Human Adipose-Derived Stem Cells

(2012) Shahnaz Razavi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Myelin Gene Regulatory Factor Is Required for Maintenance of Myelin and Mature Oligodendrocyte Identity in the Adult CNS

(2012) M. Koenning et al.   JOURNAL OF NEUROSCIENCE

Olesoxime accelerates myelination and promotes repair in models of demyelination

(2011) Karine Magalon et al.   ANNALS OF NEUROLOGY

Targets and consequences of protein SUMOylation in neurons

(2010) Kevin A. Wilkinson et al.   BRAIN RESEARCH REVIEWS

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fast bound pool fraction imaging of the in vivo rat brain: Association with myelin content and validation in the C6 glioma model

(2010) Hunter R. Underhill et al.   NEUROIMAGE

Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination

(2009) Ben Emery et al.   CELL

Two-tier transcriptional control of oligodendrocyte differentiation

(2009) Huiliang Li et al.   CURRENT OPINION IN NEUROBIOLOGY

Functional recovery of callosal axons following demyelination: a critical window

(2009) D.K. Crawford et al.   NEUROSCIENCE

What Is the Optimal Value of the g-Ratio for Myelinated Fibers in the Rat CNS? A Theoretical Approach

(2009) Taylor Chomiak et al.   PLoS One