Preferential expression of SCN1A in GABAergic neurons improves survival and epileptic phenotype in a mouse model of Dravet syndrome

SCN1A: bioinformatically-informed revised boundaries for promoter and enhancer regions

(2023) Susanna Pagni et al.   HUMAN MOLECULAR GENETICS

Adeno-Associated Virus Toolkit to Target Diverse Brain Cells

(2022) Rosemary C. Challis et al.   Annual Review of Neuroscience

Cell-selective AAV-mediated <i>SCN1A </i>Gene Regulation Therapy Rescues Mortality and Seizure Phenotypes in a Dravet Syndrome Mouse Model and is Well Tolerated in Non-human Primates

(2022) Annie Tanenhaus et al.   HUMAN GENE THERAPY

NaV1.1 haploinsufficiency impairs glutamatergic and GABAergic neuron function in the thalamus

(2022) Carleigh Studtmann et al.   NEUROBIOLOGY OF DISEASE

Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome

(2022) Joanna Mattis et al.   eLife

Functional Investigation of a Neuronal Microcircuit in the CA1 Area of the Hippocampus Reveals Synaptic Dysfunction in Dravet Syndrome Mice

(2022) Yael Almog et al.   Frontiers in Molecular Neuroscience

Genetic therapeutic advancements for Dravet Syndrome

(2022) Ellie Chilcott et al.   EPILEPSY & BEHAVIOR

GABA tonic currents and glial cells are altered during epileptogenesis in a mouse model of Dravet syndrome

(2022) Rosa Chiara Goisis et al.   Frontiers in Cellular Neuroscience

Dravet Syndrome: Advances in Etiology, Clinical Presentation, and Treatment

(2022) Zimeng He et al.   EPILEPSY RESEARCH

Application of a split‐Cre system for high‐capacity adenoviral vector amplification

(2022) Manuela Gonzalez‐Aparicio et al.   Biotechnology Journal

Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice

(2021) Jessica L. Haigh et al.   Genome Medicine

Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations

(2021) Lucia Mora-Jimenez et al.   Molecular Therapy-Nucleic Acids

SCN1A Mutation—Beyond Dravet Syndrome: A Systematic Review and Narrative Synthesis

(2021) Jiangwei Ding et al.   Frontiers in Neurology

Interneuron desynchronization precedes seizures in a mouse model of Dravet syndrome

(2020) Conny H. Tran et al.   JOURNAL OF NEUROSCIENCE

Convulsive seizures and some behavioral comorbidities are uncoupled in the Scn1a A1783V Dravet syndrome mouse model

(2020) Saja Fadila et al.   EPILEPSIA

Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans

(2020) Douglas Vormstein-Schneider et al.   NATURE NEUROSCIENCE

Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome

(2020) Zhou Han et al.   Science Translational Medicine

Developmental alterations in firing properties of hippocampal CA1 inhibitory and excitatory neurons in a mouse model of Dravet syndrome

(2020) Yael Almog et al.   NEUROBIOLOGY OF DISEASE

Influence of common SCN1A promoter variants on the severity of SCN1A ‐related phenotypes

(2019) Iris M. Lange et al.   Molecular Genetics & Genomic Medicine

Dlx5 and Dlx6 expression in GABAergic neurons controls behavior, metabolism, healthy aging and lifespan

(2019) Camille de Lombares et al.   Aging-US

dCas9-based Scn1a gene activation restores inhibitory interneuron excitability and attenuates seizures in Dravet syndrome mice

(2019) Gaia Colasante et al.   MOLECULAR THERAPY

Epilepsy and neuropsychiatric comorbidities in mice carrying a recurrent Dravet syndrome SCN1A missense mutation

(2019) Ana Ricobaraza et al.   Scientific Reports

A Method to Culture GABAergic Interneurons Derived from the Medial Ganglionic Eminence

(2018) Sira A. Franchi et al.   Frontiers in Cellular Neuroscience

Adaptation of vectors and drug-inducible systems for controlled expression of transgenes in the tumor microenvironment

(2017) Joanna Poutou et al.   JOURNAL OF CONTROLLED RELEASE

Synapsin II Regulation of GABAergic Synaptic Transmission Is Dependent on Interneuron Subtype

(2017) Pedro Feliciano et al.   JOURNAL OF NEUROSCIENCE

Resveratrol attenuates monocyte-to-macrophage differentiation and associated inflammation via modulation of intracellular GSH homeostasis: Relevance in atherosclerosis

(2016) Sathish Babu Vasamsetti et al.   FREE RADICAL BIOLOGY AND MEDICINE

A viral strategy for targeting and manipulating interneurons across vertebrate species

(2016) Jordane Dimidschstein et al.   NATURE NEUROSCIENCE

Dissecting the phenotypes of Dravet syndrome by gene deletion

(2015) Moran Rubinstein et al.   BRAIN

hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells

(2015) Brooke A. DeRosa et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Transcription of the Human Sodium Channel SCN1A Gene Is Repressed by a Scaffolding Protein RACK1

(2014) Zhao-Fei Dong et al.   MOLECULAR NEUROBIOLOGY

Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome

(2014) C. Tai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome

(2013) Ikuo Ogiwara et al.   HUMAN MOLECULAR GENETICS

Noncanonical Roles of Voltage-Gated Sodium Channels

(2013) Joel A. Black et al.   NEURON

HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice

(2012) S H MacLeod et al.   CANCER GENE THERAPY

Synaptotagmin-2 Is a Reliable Marker for Parvalbumin Positive Inhibitory Boutons in the Mouse Visual Cortex

(2012) Jean-Pierre Sommeijer et al.   PLoS One

Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

(2012) C. S. Cheah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Location of the Synaptosome-Binding Regions on Botulinum Neurotoxin B

(2011) Behzod Z. Dolimbek et al.   BIOCHEMISTRY

Dravet syndrome history

(2011) CHARLOTTE DRAVET   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Retrospective multiinstitutional study of the prevalence of early death in Dravet syndrome

(2011) Masako Sakauchi et al.   EPILEPSIA

Deletions of SCN1A 5′ genomic region with promoter activity in Dravet syndrome

(2010) Tojo Nakayama et al.   HUMAN MUTATION

A rapid protocol for construction and production of high-capacity adenoviral vectors

(2009) Lorenz Jager et al.   Nature Protocols

Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons

(2009) L. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation-based prediction of the transcription regulatory region of the SCN1A gene

(2009) Yue-Sheng Long et al.   Progress in Natural Science-Materials International

Identification of the promoter region and the 5′-untranslated exons of the human voltage-gated sodium channel Nav1.1 gene (SCN1A) and enhancement of gene expression by the 5′-untranslated exons

(2008) Yue-Sheng Long et al.   JOURNAL OF NEUROSCIENCE RESEARCH