Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities

Markers of progression in early-stage invasive breast cancer: a predictive immunohistochemical panel algorithm for distant recurrence risk stratification

(2015) Mohammed A. Aleskandarany et al.   BREAST CANCER RESEARCH AND TREATMENT

The Novolactone Natural Product Disrupts the Allosteric Regulation of Hsp70

(2015) A. Quamrul Hassan et al.   CHEMISTRY & BIOLOGY

Functionality of Class A and Class B J-protein co-chaperones with Hsp70

(2015) Hyun Young Yu et al.   FEBS LETTERS

Modulation of the Chaperone DnaK Allosterism by the Nucleotide Exchange Factor GrpE

(2015) Roberto Melero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Functional DnaK Dimer Is Essential for the Efficient Interaction with Hsp40 Heat Shock Protein

(2015) Evans Boateng Sarbeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of Intramolecular and Intermolecular Interactions in Functional Regulation of the Hsp70 J-protein Co-Chaperone Sis1

(2015) Hyun Young Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

(2015) Eugenia M. Clerico et al.   JOURNAL OF MOLECULAR BIOLOGY

Substrate-binding domain conformational dynamics mediate Hsp70 allostery

(2015) Anastasia Zhuravleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Bipartite Interaction between Hsp70 and CHIP Regulates Ubiquitination of Chaperoned Client Proteins

(2015) Huaqun Zhang et al.   STRUCTURE

Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules

(2015) Alina Röhl et al.   Nature Communications

Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90

(2015) Nina Morgner et al.   Cell Reports

Aspartic Protease Nepenthesin-1 as a Tool for Digestion in Hydrogen/Deuterium Exchange Mass Spectrometry

(2014) Alan Kadek et al.   ANALYTICAL CHEMISTRY

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

(2014) Elaine Kirschke et al.   CELL

The Assembly and Intermolecular Properties of the Hsp70-Tomm34-Hsp90 Molecular Chaperone Complex

(2014) Filip Trcka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteogenomic characterization of human colon and rectal cancer

(2014) Bing Zhang et al.   NATURE

Crystal Structure of the Stress-Inducible Human Heat Shock Protein 70 Substrate-Binding Domain in Complex with Peptide Substrate

(2014) Pingfeng Zhang et al.   PLoS One

Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop

(2014) Sara Alvira et al.   Nature Communications

Structural Insights into the Chaperone Activity of the 40-kDa Heat Shock Protein DnaJ

(2013) Jorge Cuéllar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

(2013) Ruifeng Qi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

(2013) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle

(2013) Zhuo Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain

(2013) Francesco A. Aprile et al.   PLoS One

TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome

(2012) Mohammed A. Aleskandarany et al.   BREAST CANCER RESEARCH AND TREATMENT

An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones

(2012) Anastasia Zhuravleva et al.   CELL

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

(2012) Andreas B Schmid et al.   EMBO JOURNAL

Dynamics of the regulation of Hsp90 by the co-chaperone Sti1

(2012) Chung-Tien Lee et al.   EMBO JOURNAL

The C-terminal Helices of Heat Shock Protein 70 Are Essential for J-domain Binding and ATPase Activation

(2012) Xue-Chao Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

The Lid Domain of Caenorhabditis elegans Hsc70 Influences ATP Turnover, Cofactor Binding and Protein Folding Activity

(2012) Li Sun et al.   PLoS One

Tom34: A cytosolic cochaperone of the Hsp90/Hsp70 protein complex involved in mitochondrial protein import

(2011) Pierre Faou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural Basis for the 14-3-3 Protein-dependent Inhibition of the Regulator of G Protein Signaling 3 (RGS3) Function

(2011) Lenka Rezabkova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanics of Hsp70 chaperones enables differential interaction with client proteins

(2011) Rainer Schlecht et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones

(2011) A. Zhuravleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical and structural studies on the high affinity of Hsp70 for ADP

(2011) Akihiko Arakawa et al.   PROTEIN SCIENCE

Peptide-Binding Sites As Revealed by the Crystal Structures of the Human Hsp40 Hdj1 C-Terminal Domain in Complex with the Octapeptide from Human Hsp70

(2010) Hironori Suzuki et al.   BIOCHEMISTRY

Balance between Folding and Degradation for Hsp90-Dependent Client Proteins: A Key Role for CHIP

(2010) Lenka Kundrat et al.   BIOCHEMISTRY

Versatile TPR domains accommodate different modes of target protein recognition and function

(2010) Rudi Kenneth Allan et al.   CELL STRESS & CHAPERONES

Gymnastics of Molecular Chaperones

(2010) Matthias P. Mayer   MOLECULAR CELL

NMR Characterizations of the Ice Binding Surface of an Antifreeze Protein

(2010) Jiang Hong et al.   PLoS One

Electrostatic Interactions of Hsp-organizing Protein Tetratricopeptide Domains with Hsp70 and Hsp90

(2009) Tommi Kajander et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric Coupling between the Lid and Interdomain Linker in DnaK Revealed by Inhibitor Binding Studies

(2008) M. Liebscher et al.   JOURNAL OF BACTERIOLOGY

Structural Studies on the Co-chaperone Hop and Its Complexes with Hsp90

(2008) S.C. Onuoha et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

(2008) Zhen Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK

(2007) Lyra Chang et al.   ANALYTICAL BIOCHEMISTRY