Review
Pharmacology & Pharmacy
Chu-Yang Zeng, Xi-Feng Wang, Fu-Zhou Hua
Summary: Osteoarthritis is a common degenerative disease associated with age, for which there are currently no established cures. Understanding the mechanisms involved in the onset and progression of osteoarthritis is crucial for developing new preventive and therapeutic strategies. This review summarizes the role of hypoxia in the pathogenesis of osteoarthritis and focuses on therapeutic treatments targeting HIF-1 alpha. Further elucidation of the regulatory mechanisms of HIF-1 alpha in osteoarthritis may provide valuable insights for the development of novel osteoarthritis treatment strategies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Lu Yu, Yulin Wang, Yan Hong Guo, Liuwei Wang, Zijun Yang, Zi Han Zhai, Lin Tang
Summary: HIF-1 alpha-mediated mitophagy plays a protective role in diabetic nephropathy, preventing apoptosis and ROS production.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Prasad Sulkshane, Jonathan Ram, Anita Thakur, Noa Reis, Oded Kleifeld, Michael H. Glickman
Summary: The study reveals that damaged mitochondria can be cleared via Parkin-independent mitophagy under oxidative stress conditions induced by hypoxia or CoCl2. The process involves extensive ubiquitination and degradation of key mitochondrial proteins, independent of the five ubiquitin-binding autophagy receptors. Additionally, the clearance of oxidation-damaged mitochondria relies on DRP1-mediated mitochondrial fragmentation and BNIP3/NIX-mediated mitophagy.
Article
Biochemistry & Molecular Biology
Zhilong Ren, Duilio Michele Potenza, Yiqiong Ma, Guillaume Ajalbert, David Hoogewijs, Xiu-Fen Ming, Zhihong Yang
Summary: Hypoxia causes injury to podocytes, and the presence of Arg-II in podocytes contributes to this injury. However, the elimination of Arg-II does not significantly affect hypoxia-induced albuminuria, but it does reduce albuminuria in aging.
Article
Pharmacology & Pharmacy
Zhouliang Guo, Yang Yang, Lu Li, Qing Zhao, Yuyin Li, Zhenxing Liu, Limin Hao, Baoqiang Guo, Aipo Diao
Summary: This study identifies caffeic acid as a novel PHD2 inhibitor that activates the hypoxia-associated transcription factor HIF, leading to a neuroprotective effect against hypoxia.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Physiology
Ruiqin Hu, Genfang Li, Qianghua Xu, Liangbiao Chen
Summary: This study investigated the role of iron in the hypoxic responses of two zebrafish-derived cell lines. The results showed that iron homeostasis is important for maintaining mitochondrial integrity in hypoxic stress, and this effect is cell type-dependent.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cell Biology
Nasim Kheshtchin, Jamshid Hadjati
Summary: Hypoxia, a common characteristic of solid tumors, contributes to different aspects of tumor progression and limits the efficacy of immunotherapies. Developing new immunotherapy strategies involving therapeutic targeting of HIF-1 molecules associated with hypoxia may enhance the clinical effectiveness of immunotherapy. Targeting hypoxia presents a potential opportunity to improve the clinical benefit of cancer immunotherapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elena Monti, Alessandro Mancini, Emanuela Marras, Marzia Bruna Gariboldi
Summary: Experimental evidence suggests that mitochondrial ROS plays a pivotal role in hypoxia-induced Epithelial-Mesenchymal Transition (EMT), and inhibiting mitochondrial ROS production could reverse EMT. UQCRB is a key factor in hypoxic signaling-induced EMT and may serve as a new therapeutic target for drug development.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Orthopedics
Feng Wang, Ting Zhou, Chen Xu Zhou, Quan Bing Zhang, Hua Wang, Yun Zhou
Summary: This study investigated the effects of remobilization on skeletal muscle and the role of BNIP3-dependent mitophagy. Within the first three days of remobilization, rats exhibited decreased muscle weight-to-body weight ratio, cross-sectional area, and ATP concentration, along with increased ROS production and HIF-1a protein levels in skeletal muscle. Results also indicated sustained activation of BNIP3-dependent mitophagy during remobilization, which may contribute to skeletal muscle atrophy.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Federica Barreca, Michele Aventaggiato, Laura Vitiello, Luigi Sansone, Matteo Antonio Russo, Antonello Mai, Sergio Valente, Marco Tafani
Summary: This study suggests that activation of SIRT5 and reduction in Pi could be a valid strategy to inhibit cell proliferation by reducing glutamine metabolism and mitophagy, leading to the accumulation of ROS.
Article
Oncology
Francisca Valenzuela-Molina, Florina I. Bura, Mari C. Vazquez-Borrego, Melissa Granados-Rodriguez, Blanca Rufian-Andujar, Sebastian Rufian-Pena, Angela Casado-Adam, Juan Manuel Sanchez-Hidalgo, Lidia Rodriguez-Ortiz, Rosa Ortega-Salas, Ana Martinez-Lopez, Carmen Michan, Jose Alhama, Alvaro Arjona-Sanchez, Antonio Romero-Ruiz
Summary: This study demonstrated for the first time the presence of low intratumoral oxygen levels and increased markers of hypoxia and oxidative stress in PMP patients. However, more research is needed to understand the potential role of oxidative stress in PMP and develop new therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Mengqing Xiong, Yang Zhao, Huaheng Mo, Haizhen Yang, Fang Yue, Ke Hu
Summary: The study revealed that intermittent hypoxia exacerbated BLM-induced pulmonary fibrosis, with higher expression of ROS and HIF-1 alpha related to oxidative stress and inflammation. There was a positive linear correlation between HIF-1 alpha expression and hydroxyproline content, as well as a positive correlation between inflammation and ROS expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maciej Jaskiewicz, Adrianna Moszynska, Jaroslaw Kroliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzynska, Magda Gebert, Michal Dabrowski, James F. Collawn, Rafal Bartoszewski
Summary: HIF is a transcription factor that activates the adaptive hypoxic response during low oxygen levels. HIF-1 and HIF-2 mediate this response in a sequential manner, but their transcriptional profiles differ and the transition between them is not well understood.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
O. Petteri Hirvonen, Maarit Lehti, Heikki Kyrolainen, Heikki Kainulainen
Summary: Small doses of oral D-glyceric acid (DGA) have been shown to activate mitochondrial metabolism and reduce inflammation. The present study reveals that after a 4-day DGA regimen, a dose of DGA can acutely activate the HO-1 pathway, while long-term DGA regimen may downregulate the HO-1 pathway. These findings are important for the prevention of chronic diseases, especially aging-related diseases.
Review
Pharmacology & Pharmacy
Yijie Wang, Xiong Liu, Weixiao Huang, Junjie Liang, Yan Chen
Summary: Alterations in protein ubiquitination and HIF signaling contribute to tumorigenesis and tumor progression. ROS upregulation in tumors has multiple effects on HIF signaling and the ubiquitin system. Multiple E3 ligases and UBDs work together to regulate the expression and activity of HIF, helping cancer cells cope with hypoxia. Understanding the complex networks between E3 ligase, UBDs, ROS, and HIF provides insights into the cellular response to hypoxia and identifies novel molecular targets for cancer treatment.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Cell Biology
Christopher L. Souders, Jasenka Zubcevic, Christopher J. Martyniuk
Summary: The colonic epithelium plays a crucial role in the production and transport of vasoactive metabolites and neurotransmitters that modulate the immune system, affect cellular metabolism, and regulate blood pressure. Inflammation in the colon and microbial metabolites have been highlighted in the pathology of hypertension, particularly the interaction between TNF alpha and SCFA metabolites. This review identifies novel pathways in the colonic epithelium related to hypertension and emphasizes the complexity of host-microbiota interactions in regulating blood pressure and metabolic function.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Environmental Sciences
Bernard Robaire, Geraldine Delbes, Jessica A. Head, Vicki L. Marlatt, Christopher J. Martyniuk, Stephane Reynaud, Vance L. Trudeau, Jan A. Mennigen
Summary: Studies have mainly focused on the effects of EDCs on adult males and females, but exposure of mature or developing gametes can lead to multigenerational and transgenerational effects. By synthesizing knowledge across vertebrate species, potential mechanisms of EDC effects are discussed, and recommendations for advancing the field are proposed.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
V. L. Marlatt, S. Bayen, D. Castaneda-Cortes, G. Delbes, P. Grigorova, V. S. Langlois, C. J. Martyniuk, C. D. Metcalfe, L. Parent, A. Rwigemera, P. Thomson, G. Van der Kraak
Summary: This review summarizes the current knowledge of the impacts of EDCs on reproductive success in wildlife and humans, with a focus on retrospective assessment and laboratory-based experiments. The evidence suggests that anthropogenic chemicals negatively impact reproduction by altering endocrine system function, particularly in aquatic species. Similar effects are observed in mammalian wildlife and humans in epidemiological studies. Further research is needed on the implications of chemical exposures during development and the potential for long-term reproductive effects. Field-based observations and long-term population level studies are key to addressing knowledge gaps.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Julie Robitaille, Nancy D. Denslow, Beate Escher, Hajime G. Kurita-Oyamada, Vicki Marlatt, Christopher J. Martyniuk, Laia Navarro-Martin, Ryan Prosser, Thomas Sanderson, Viviane Yargeau, Valerie S. Langlois
Summary: This paper discusses the hazards of endocrine disrupting chemicals (EDCs) in water resources, the potential bioassays for screening EDCs, advantages and limitations of sample preparation methods, and provides several key recommendations.
ENVIRONMENTAL RESEARCH
(2022)
Article
Engineering, Environmental
Jiye Zhang, Huihui Chen, Tianheng Tong, Ruimin Liu, Saihong Yan, Xuefang Liang, Christopher J. Martyniuk, Jinmiao Zha
Summary: Asian clams (Corbicula fluminea) exposed to different concentrations of Benzotriazole ultraviolet stabilizers (BUVSs) showed varying physiological and molecular toxic effects, including changes in filtration rate, histopathological changes, and induction of apoptosis. This study provides important insights into the toxicity and hazards of BUVSs in benthic organisms.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Emma Ivantsova, Isaac Konig, Christopher L. Souders II, David McNabney, Denina D. B. Simmons, Christopher J. Martyniuk
Summary: Blood pressure medication atenolol, a beta-blocker detected in wastewater systems, has negative effects on early stages of zebrafish development. It affects survival, heart rate, mitochondrial function, lipid and amino acid profiles, and locomotor activity. Atenolol decreases heart rate and alters lipid content in zebrafish at environmentally relevant levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Nazish Iftikhar, Isaac Konig, Cole English, Emma Ivantsova, Christopher L. L. Souders II, Imran Hashmi, Christopher J. J. Martyniuk
Summary: The broad-range bacteriostatic antibiotic sulfamethoxazole (SMX) has been found to have sub-lethal toxicity effects on developing zebrafish embryos and larvae, including decreased survivability, delayed hatch, and induced malformations. It also triggers an inflammatory response and alters the expression of genes related to apoptosis. These findings contribute to the understanding of antibiotic toxicity in aquatic organisms and provide a foundation for environmental risk assessment of SMX and other antibiotics.
Article
Multidisciplinary Sciences
Cole D. English, Kira J. Kazi, Isaac Konig, Emma Ivantsova, Christopher L. Souders Ii, Christopher J. Martyniuk
Summary: Zebrafish larvae were exposed to different concentrations of Ifosfamide, and RNA-seq analysis revealed 21 microRNAs that were associated with Ifosfamide exposure. This study provides valuable insights for the advancement of regulatory toxicology and biomarker discovery in aquatic environments.
Article
Environmental Sciences
Mohamed Hamed, Christopher J. Martyniuk, Rashad E. M. Said, Hamdy A. M. Soliman, Ahmed E. A. Badrey, Elhagag A. Hassan, Hani N. Abdelhamid, Alaa G. M. Osman, Alaa El -Din H. Sayed
Summary: This study reports the presence of pyrogallol in wastewater in Egypt for the first time. Acute and sub-acute toxicity experiments were conducted to evaluate the toxic effects of pyrogallol on catfish. The results showed that pyrogallol exposure caused morphological changes, hematological and biochemical alterations, indicating potential risks to aquatic species.
ENVIRONMENTAL POLLUTION
(2023)
Article
Endocrinology & Metabolism
Chunyu Lu, Di Peng, W. C. K. Udeesha Erandani, Kimberly Mitchell, Christopher J. Martyniuk, Vance L. Trudeau
Summary: The detection and quantification of hormones are crucial for assessing experimental models and diagnosing diseases. Traditional methods involve separate experiments, while the new approach allows simultaneous measurement of different categories of hormones. This study presents a novel sample processing strategy for the simultaneous extraction and detection of peptides, steroids, and proteins.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Sarah J. Patuel, Cole English, Victoria Lopez-Scarim, Isaac Konig, Christopher L. Souders II, Emma Ivantsova, Christopher J. Martyniuk
Summary: The study investigates the effects of Broflanilide, a novel pesticide, on zebrafish larvae. It reveals that exposure to different concentrations of Broflanilide can impact gene networks associated with various neurological disorders, including axonal injury, depression, neuroinflammation, brain infarction, and excitotoxicity. The study also identifies genes related to MPTP-induced neurotoxicity, which has relevance for Parkinson's disease.
Article
Environmental Sciences
David W. Bertolatus, Larry B. Barber, Christopher J. Martyniuk, Huajun Zhen, Timothy W. Collette, Drew R. Ekman, Aaron Jastrow, Jennifer L. Rapp, Alan M. Vajda
Summary: In order to evaluate the relationships between anthropogenic impacts, contaminant occurrence, and fish health, fish exposures were conducted across different land use sites in the Shenandoah River watershed. The study found adverse reproductive outcomes and increased mortality in fish exposed to wastewater treatment plant effluent and agricultural impacts. Molecular biomarkers and hepatic metabolomic and transcriptomic profiles indicated variations in land use and contaminant profiles. This study demonstrated the linkages between human impacts, contaminant occurrence, and exposure effects, highlighting the increased risk of adverse outcomes in fish exposed to complex mixtures.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Isaac Konig, Nazish Iftikhar, Evelyn Henry, Cole English, Emma Ivantsova, Christopher L. Souders II, Silvana Marcussi, Christopher J. Martyniuk
Summary: This study compared the toxicity of carvacrol, acetylcarvacrol, and fipronil to early staged zebrafish. The results showed that carvacrol and its derivative have lower acute toxicity compared to fipronil.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Sarah J. Patuel, Cole English, Victoria Lopez-Scarim, Isaac Konig, Christopher L. Souders II, Emma Ivantsova, Christopher J. Martyniuk
Summary: This study evaluates the sub-lethal toxicity potential of broflanilide in early staged zebrafish and finds that the insecticide has minimal impact on survival and biochemical parameters of the fish but can induce neurotoxicity and motor dysfunction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)