SARS‐CoV‐2 ORF7a blocked autophagy flux by intervening in the fusion between autophagosome and lysosome to promote viral infection and pathogenesis

SARS-CoV-2 ORF7a protein blocks virus clearance by regulating autophagy

(2023) Huimei Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Evaluation of SARS-CoV-2 ORF7a Deletions from COVID-19-Positive Individuals and Its Impact on Virus Spread in Cell Culture

(2023) Maria Clara da Costa Simas et al.   Viruses-Basel

Omicron variant of SARS‐CoV‐2: Genomics, transmissibility, and responses to current COVID‐19 vaccines

(2022) Yusha Araf et al.   JOURNAL OF MEDICAL VIROLOGY

SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection

(2022) Xiaolin Zhang et al.   Autophagy

KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity

(2022) Guokai Yan et al.   Autophagy

SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5

(2022) Uddhav Timilsina et al.   Nature Communications

Coronavirus Usurps the Autophagy-Lysosome Pathway and Induces Membranes Rearrangement for Infection and Pathogenesis

(2022) Haowei Liang et al.   Frontiers in Microbiology

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication

(2022) Peili Hou et al.   Autophagy

SARS‐CoV‐2 ORF10 antagonizes STING‐dependent interferon activation and autophagy

(2022) Lulu Han et al.   JOURNAL OF MEDICAL VIROLOGY

Ubiquitination of SARS-CoV-2 ORF7a Prevents Cell Death Induced by Recruiting BclXL To Activate ER Stress

(2022) Zhixin Liu et al.   Microbiology Spectrum

Impairment of antiviral immune response and disruption of cellular functions by SARS-CoV-2 ORF7a and ORF7b

(2022) Tránsito García-García et al.   iScience

Micro-PET imaging of hepatitis C virus NS3/4A protease activity using a protease-activatable retention probe

(2022) Chih-Hung Chuang et al.   Frontiers in Microbiology

A novel cell culture system modeling the SARS-CoV-2 life cycle

(2021) Xiaohui Ju et al.   PLoS Pathogens

Structural insight reveals SARS-CoV-2 ORF7a as an immunomodulating factor for human CD14+ monocytes

(2021) Ziliang Zhou et al.   iScience

Two conserved oligomer interfaces of NSP7 and NSP8 underpin the dynamic assembly of SARS-CoV-2 RdRP

(2021) Mahamaya Biswal et al.   NUCLEIC ACIDS RESEARCH

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

(2021) Yabin Zhang et al.   Cell Discovery

miR‐148a‐3p silences the CANX/MHC‐I pathway and impairs CD8 + T cell‐mediated immune attack in colorectal cancer

(2021) Jinxiu Zheng et al.   FASEB JOURNAL

The SARS-CoV-2 Nucleocapsid Protein and Its Role in Viral Structure, Biological Functions, and a Potential Target for Drug or Vaccine Mitigation

(2021) Zhihua Bai et al.   Viruses-Basel

Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2

(2021) Shaojun Zhang et al.   CELL RESEARCH

Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses

(2021) Saathvik R. Kannan et al.   JOURNAL OF AUTOIMMUNITY

Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China

(2020) Fei Yu et al.   MICROBES AND INFECTION

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy

(2020) Domenico Benvenuto et al.   JOURNAL OF INFECTION

The hallmarks of COVID-19 disease

(2020) Daolin Tang et al.   PLoS Pathogens

The Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1

(2020) Huifang Zhu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

(2020) Jin-Yan Li et al.   VIRUS RESEARCH

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

(2020) Sourish Ghosh et al.   CELL

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes

(2019) Juan-Vicente Bou et al.   Cell Reports

Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir

(2019) Jennifer Timm et al.   ACS Chemical Biology

Evaluating the inhibitory effect of eight compounds from Daphne papyracea against the NS3/4A protease of hepatitis C virus

(2018) Ying Wei et al.   NATURAL PRODUCT RESEARCH

Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease

(2016) Victor L. Perez et al.   Ocular Surface

Viruses and the autophagy pathway

(2015) William T. Jackson   VIROLOGY

Virus-induced double-membrane vesicles

(2014) Emmanuelle Blanchard et al.   CELLULAR MICROBIOLOGY

Coxsackievirus B Exits the Host Cell in Shed Microvesicles Displaying Autophagosomal Markers

(2014) Scott M. Robinson et al.   PLoS Pathogens

Restoration of Type I Interferon Expression by Heme and Related Tetrapyrroles Through Inhibition of NS3/4A Protease

(2013) Zhaowen Zhu et al.   JOURNAL OF INFECTIOUS DISEASES

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles

(2013) M. M. Angelini et al.   mBio

Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus

(2011) Ann D Kwong et al.   NATURE BIOTECHNOLOGY