Article
Pathology
Yoshihiro Ito, Kenichi Kohashi, Makoto Endo, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yosuke Susuki, Kengo Kawaguchi, Hiroshi Furukawa, Yuki Tateishi, Yuichi Yamada, Izumi Kinoshita, Taro Mori, Hidetaka Yamamoto, Yasuharu Nakashima, Yoshinao Oda
Summary: Loss of H3K27 methylation may be a useful diagnostic marker for MPNST, with significant correlations to certain pathological and immunohistochemical features. In multivariate analysis, local recurrence, distant metastasis, high FNCLCC grade, and loss of SOX10 expression were identified as independent prognostic factors for overall survival in MPNST patients.
Article
Pathology
Shin Ishihara, Hidetaka Yamamoto, Takeshi Iwasaki, Yu Toda, Takeo Yamamoto, Masato Yoshimoto, Yoshihiro Ito, Yousuke Susuki, Kengo Kawaguchi, Izumi Kinoshita, Yuichi Yamada, Kenichi Kohashi, Toshifumi Fujiwara, Nokitaka Setsu, Makoto Endo, Yoshihiro Matsumoto, Yuko Kakuda, Yasuharu Nakashima, Yoshinao Oda
Summary: This study aimed to elucidate the clinicopathologic and molecular features of malignant giant cell tumors of bone (MGCTBs) through immunohistochemistry, fluorescence in situ hybridization (FISH) and next generation sequencing (NGS). The results suggested that p53 alteration and dysfunction of histone methylation as evidenced by H3K27me3 loss may play an important role in the malignant progression of GCTB. The combined histologic, immunohistochemical and molecular information may be helpful for the diagnosis of challenging cases.
Article
Veterinary Sciences
Kristina Tekavec, Tanja Svara, Tanja Knific, Jernej Mlakar, Mitja Gombac, Carlo Cantile
Summary: Nerve sheath tumors (NSTs) are characterized by abnormal cell growth in various types of cells. Loss of H3K27me3 expression in a subset of MNSTs has been identified as a potential diagnostic marker. In a study of 68 canine tumors previously diagnosed as NST, 25% showed loss of H3K27me3 expression, 49% had mosaic loss of expression, and 26% retained expression. However, there were no significant correlations between H3K27me3 expression and histopathological features or other markers. More research is needed to evaluate the diagnostic value of H3K27me3 loss in canine NST.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Oncology
Giulio Bonomo, Alessandro Gans, Elio Mazzapicchi, Emanuele Rubiu, Paolo Alimonti, Marica Eoli, Rosina Paterra, Bianca Pollo, Guglielmo Iess, Francesco Restelli, Jacopo Falco, Francesco Acerbi, Marco Paolo Schiariti, Paolo Ferroli, Morgan Broggi
Summary: In this paper, the clinical and diagnostic features of Sporadic Spinal Psammomatous Malignant Melanotic Nerve Sheath Tumor (SSP-MMNST) are reviewed, and possible pathogenetic mechanisms are investigated to improve therapeutic strategies. A case of a young female with SSP-MMNST arising from C5-6 right spinal roots is also reported. The study found that SSP-MMNST has a high recurrence rate and residual disease is associated with a higher risk of systemic disease spreading, suggesting the importance of adjuvant radiation therapy.
FRONTIERS IN ONCOLOGY
(2023)
Letter
Oncology
John Lennon Silva Cunha, Saygo Tomo, Ederson Kerlakian de Paiva Gomes Fernandes, Margarite Maria Delmondes Freitas, Oslei Paes de Almeida, Bruno Augusto Benevenuto de Andrade, Ciro Dantas Soares, Ricardo Luiz Cavalcanti de Albuquerque-Junior
Summary: This study reports a rare case of intraosseous MPNST in a 28-year-old male without neurofibromatosis type 1, discovered as an incidental finding on imaging exam. After wide surgical resection, the patient remained with no evidence of recurrence or metastatic disease during a three-year follow-up.
Article
Acoustics
Zhenzhen Jin, Kaiping Zhao, Wen Guo, Dandan Wang, Yukun Deng, Tao Chen
Summary: This study aimed to differentiate malignant peripheral nerve sheath tumors (MPNSTs) from benign peripheral nerve sheath tumors (BPNSTs) using sonography. Key features were identified, and a scoring system was established. The results demonstrated the effectiveness of sonography in differentiating between MPNSTs and BPNSTs.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Oncology
Sumanth Nagabushan, Loretta M. S. Lau, Paulette Barahona, Marie Wong, Alexandra Sherstyuk, Glenn M. Marshall, Vanessa Tyrrell, Eva A. Wegner, Paul G. Ekert, Mark J. Cowley, Chelsea Mayoh, Toby N. Trahair, Philip Crowe, Antoinette Anazodo, David S. Ziegler
Summary: The prognosis of recurrent malignant peripheral nerve sheath tumors (MPNST) is poor and surgical resection remains the main treatment option. Chemoradiation approaches have not significantly improved outcomes, while therapies targeting genomic drivers of MPNST have been unsuccessful. MEK inhibitors show promise in preclinical studies but clinical efficacy remains unknown.
NPJ PRECISION ONCOLOGY
(2021)
Article
Oncology
Daniel Feucht, Susanne R. Kerscher, Christer Ruff, Martin U. Schuhmann, Constantin Roder, Julian Zipfel
Summary: Assessing GBM patients with MRI revealed the potential of ONSD to identify high ICP. Preoperative increase in ONSD was associated with edema, while postoperatively ONSD decreased until 3 months after surgery and increased again at 12 months. Further prospective data collection is warranted for validation.
Review
Radiology, Nuclear Medicine & Medical Imaging
Mitchell P. Wilson, Prayash Katlariwala, Gavin Low, Mohammad H. Murad, Matthew D. F. McInnes, Line Jacques, Andrew S. Jack
Summary: This systematic review and meta-analysis evaluated the diagnostic accuracy of MRI for differentiating malignant from benign peripheral nerve sheath tumors. The study found that combining features such as diffusion restriction can optimize the diagnostic accuracy of MRI for detecting MPNSTs.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ziyu Guo, Wei Liu, Ziqian Dong, Lan Yang, Peng Xie
Summary: This is a rare case of malignant peripheral nerve sheath tumor involving the solitary lumbar vertebra. The patient presented with growing lumbocrural pain for 2 months. CT scan revealed a solitary vertebral lesion, highly suggestive of metastatic malignancy. F-18-FDG PET/CT showed heterogeneous intense FDG accumulation in the vertebral lesion with an SUVmax of 16.4. Pathological examination confirmed the diagnosis of malignant peripheral nerve sheath tumor. This case highlights the importance of considering MPNST when there is solitary vertebra invasion with increased FDG uptake.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Clinical Neurology
Megan C. Everson, Courtney Pendleton, Megan M. Jack, Brandon W. Smith, Jodi M. Carter, Robert J. Spinner
Summary: Malignant perineurioma is a rare subset of MPNST with distinct clinical features. Patients in the study had uncomplicated clinical courses post-diagnosis, but further research is needed to fully understand the clinical course of these rare tumors.
WORLD NEUROSURGERY
(2021)
Article
Pathology
Judith Jebastin Thangaiah, Brooke E. Westling, Anja C. Roden, Caterina Giannini, Michael Tetzlaff, Woo Cheal Cho, Andrew L. Folpe
Summary: Loss of H3K27me2 is not specific to MPNST and is also seen in other tumors, especially those in the blue nevus family.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2022)
Article
Clinical Neurology
Michael Zhang, Elizabeth Tong, Forrest Hamrick, Edward H. Lee, Lydia T. Tam, Courtney Pendleton, Brandon W. Smith, Nicholas F. Hug, Sandip Biswal, Jayne Seekins, Sarah A. Mattonen, Sandy Napel, Cynthia J. Campen, Robert J. Spinner, Kristen W. Yeom, Thomas J. Wilson, Mark A. Mahan
Summary: This study developed a machine learning approach using high-dimensional radiomics features and clinical data to differentiate benign from malignant peripheral nerve sheath tumors (PNSTs). The method achieved high specificity and AUC on the test set, outperforming human experts in tumor classification.
Article
Multidisciplinary Sciences
Sabrina H. Rossi, Izzy Newsham, Sara Pita, Kevin Brennan, Gahee Park, Christopher G. Smith, Radoslaw P. Lach, Thomas Mitchell, Junfan Huang, Anne Babbage, Anne Y. Warren, John T. Leppert, Grant D. Stewart, Olivier Gevaert, Charles E. Massie, Shamith A. Samarajiwa
Summary: Current diagnostic strategies are unable to differentiate between benign and malignant small renal masses accurately, leading to unnecessary surgery in 20% of patients. The MethylBoostER machine learning model, utilizing DNA methylation data, can classify pathological subtypes of renal tumors and provide a more confident presurgical diagnosis, potentially improving treatment decision-making.
Article
Multidisciplinary Sciences
Jody Fromm Longo, Stephanie N. Brosius, Iya Znoyko, Victoria A. Alers, Dorea P. Jenkins, Robert C. Wilson, Andrew J. Carroll, Daynna J. Wolff, Kevin A. Roth, Steven L. Carro
Summary: This article introduces a new sporadic MPNST cell line, 2XSB, with molecular and genomic features similar to the parent tumor, providing a useful tool for investigating the biology and potential treatment regimens for sporadic MPNSTs. The cells display invasive capabilities and form solid tumors when xenografted into immunodeficient mice, and genomic analyses reveal mutations in key genes implicated in MPNST pathogenesis.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Silvia Stacchiotti, Hans Roland Duerr, Inga-Marie Schaefer, Klaus Woertler, Rick Haas, Annalisa Trama, Augusto Caraceni, Jyoti Bajpai, Giacomo Giulio Baldi, Nicholas Bernthal, Jean-Yves Blay, Kjetil Boye, Javier-Martin Broto, Wei-Wu Tom Chen, Paolo Angelo Dei Tos, Jayesh Desai, Stephan Emhofer, Mikael Eriksson, Alessandro Gronchi, Hans Gelderblom, Jendrik Hardes, Wolfgang Hartmann, John Healey, Antoine Italiano, Robin L. Jones, Akira Kawai, Andreas Leithner, Herbert Loong, Eric Mascard, Carlo Morosi, Nadine Otten, Emanuela Palmerini, Shreyaskumar R. Patel, Peter Reichardt, Brian Rubin, Piotr Rutkowski, Claudia Sangalli, Kathrin Schuster, Beatrice M. Seddon, Morena Shkcodra, Eric L. Staals, William Tap, Matt van de Rijn, Kirsten van Langevelde, Filip M. M. Vanhoenacker, Andrew Wagner, Lisette Wiltink, Sydney Stern, Michiel Van de Sande, Sebastian Bauer
Summary: Tenosynovial giant cell tumour (TGCT) is a rare, locally aggressive tumor that arises from the joints, bursa, and tendon sheaths. There are two types of TGCT: nodular and diffuse, with the former exhibiting a slow disease course and the latter showing locally aggressive behavior. Although not life-threatening, TGCT can cause chronic pain and negatively impact function and quality of life. CSFR1 inhibitors are effective in treating TGCT but are not widely available. The lack of guidelines and uncertainty in selecting appropriate therapy lead to inconsistent adoption of new treatments and suboptimal outcomes for patients. A global consensus meeting was held in June 2022 to develop evidence-based recommendations for the optimal management of TGCT.
CANCER TREATMENT REVIEWS
(2023)
Article
Pathology
Arjen H. G. Cleven, Karoly Szuhai, David G. P. van IJzendoorn, Eline Groen, Hans Baelde, Willem H. Schreuder, Inge H. Briaire-de Bruijn, Stijn W. van der Meeren, Maarten C. Kleijwegt, Wouter R. Furth, Herman M. Kroon, Albert J. H. Suurmeijer, Dilara C. Savci-Heijink, Daniel Baumhoer, Judith V. M. G. Bovee
Summary: Psammomatoid ossifying fibroma (PsOF) is a benign fibro-osseous neoplasm that mainly affects extragnathic bones, especially the frontal and ethmoid bones, in adolescents and young adults. Identifying the specific genes involved in chromosomal breakpoints and their frequency in PsOF can improve diagnostic accuracy. SATB2 rearrangement is a recurrent molecular alteration specific to PsOF and distinguishes it from other related diseases.
Article
Cell Biology
Myung Chang Lee, Hongchen Cai, Christopher W. Murray, Chuan Li, Yan Ting Shue, Laura Andrejka, Andy L. He, Alessandra M. E. Hozlem, Alexandros P. Drainans, Julie H. Ko, Garry L. Coles, Christina Kong, Shirley Zhu, ChunFang Zhu, Jason Wang, Matt van de Rijn, Dmitri A. Petrov, Monte M. Winslow, Julien Sage
Summary: We developed a quantitative multiplexed approach based on lentiviral barcoding and CRISPR-Cas9-mediated genome editing to functionally study candidate regulators of tumor initiation and growth in small cell lung cancer (SCLC). Naphthalene pre-treatment enhanced lentiviral vector-mediated SCLC initiation and enabled high-throughput sequencing analysis of tumor clones. The analysis identified TSC1 in the PI3K-AKT-mTOR pathway as a robust tumor suppressor in SCLC. This approach will provide insight into drivers of SCLC and facilitate the development of precision therapies for specific SCLC genotypes.
Article
Oncology
Nam Q. Bui, Neda Nemat-Gorgani, Ajay Subramanian, Ileana A. Torres, Marta Lohman, Timothy J. Sears, Matt van de Rijn, Gregory W. Charville, Hans-Christoph Becker, David S. Wang, Gloria L. Hwang, Kristen N. Ganjoo, Everett J. Moding
Summary: This study evaluated the role of circulating tumor DNA (ctDNA) as a biomarker in monitoring treatment response in patients with advanced soft tissue sarcomas (STS). The results showed that ctDNA was associated with treatment response, progression-free survival, and overall survival. This suggests that ctDNA may serve as a promising biomarker in STS patients.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Gabriele Romano, Francesca Paradiso, Peng Li, Pooja Shukla, Lindsay N. Barger, Olivia El Naggar, John P. Miller, Roger J. Liang, Timothy L. Helms, Alexander J. Lazar, Jennifer A. Wargo, Francesca Taraballi, James C. Costello, Lawrence N. Kwong
Summary: Patients with BRAF-mutant melanoma respond well to combined BRAF and MEK inhibition, but relapse is common within 2 years. Minimal residual disease (MRD), which consists of drug-tolerant tumor cells in a dormant state, is a major cause of drug resistance. By studying a mouse model, researchers found that sustaining chemokine signaling can impair MRD maintenance by increasing the recruitment of effector T cells.
CANCER IMMUNOLOGY RESEARCH
(2023)
Review
Oncology
Brandon M. Cope, Raymond S. Traweek, Rossana Lazcano, Emily Z. Keung, Alexander J. Lazar, Christina L. Roland, Elise F. Nassif
Summary: Immunotherapy has greatly improved cancer care, but leiomyosarcoma is not responsive to early immune-based therapies. This review discusses the results of immunotherapy trials in leiomyosarcoma and highlights the differences between soft-tissue and uterine leiomyosarcomas. It also explores the molecular subgroups of leiomyosarcomas and their impact on response to immune checkpoint blockade, proposing future directions for improving immunotherapy in leiomyosarcoma patients. Leiomyosarcoma is a rare and aggressive tumor with low tumor mutational burden, frequent alterations in certain genes, and a highly infiltrated immune microenvironment. This review provides insights for the development of biomarker-based immune therapies.
Article
Multidisciplinary Sciences
Shirley Greenbaum, Inna Averbukh, Erin Soon, Gabrielle Rizzuto, Alex Baranski, Noah F. Greenwald, Adam Kagel, Marc Bosse, Eleni G. Jaswa, Zumana Khair, Shirley Kwok, Shiri Warshawsky, Hadeesha Piyadasa, Mako Goldston, Angie Spence, Geneva Miller, Morgan Schwartz, Will Graf, David Van Valen, Virginia D. Winn, Travis Hollmann, Leeat Keren, Matt van de Rijn, Michael Angelo
Summary: A spatiotemporal atlas of the human maternal-fetal interface in the first half of pregnancy was constructed using a multiomics approach. The study revealed that gestational age significantly influenced the frequency of maternal immune and stromal cells, with tolerogenic subsets becoming enriched at later time points. Spiral artery remodeling was primarily correlated with extravillous trophoblast invasion and was defined by distinct transcriptional pathways.
Review
Oncology
Djoko Santoso, Mochammad Thaha, Maulana A. Empitu, Ika Nindya Kadariswantiningsih, Satriyo Dwi Suryantoro, Mutiara Rizki Haryati, Decsa Medika Hertanto, Dana Pramudya, Siprianus Ugroseno Yudho Bintoro, Nasronudin Nasronudin, Mochamad Yusuf Alsagaff, Hendri Susilo, Citrawati Dyah Kencono Wungu, Nicolaas C. Budhiparama, Pancras C. W. Hogendoorn
Summary: Osteitis fibrosa cystica (OFC) and Brown Tumours are rare bone lesions associated with chronic kidney disease. The mechanism of these conditions is not well understood, but recent literature suggests that factors such as overactivation of the renin-angiotensin-aldosterone system and chronic inflammation may contribute to their occurrence through osteoclast activation. In addition, hotspot KRAS mutations have been identified in these lesions, placing them in the spectrum of RAS-MAPK-driven neoplasms. Risk factors for OFC and Brown Tumours include age, gender, comorbidities, and certain medications. Diagnosis involves clinical symptoms of chronic bone pain and laboratory findings of hyperparathyroidism, as well as radiological imaging and histological examination.
Review
Oncology
Sanne Venneker, Judith V. M. G. Bovee
Summary: Chondrosarcomas frequently carry isocitrate dehydrogenase (IDH) gene mutations and these mutations play a significant role in early stages of cartilage tumour development. However, their role in later stages remains unclear. Other types of IDH mutant tumours have shown the impact of this mutation on patient outcomes and therapies. Factors such as tumour type, elevated oncometabolite levels, the type of model used in preclinical studies, and additional (epi)genetic alterations could explain the discrepancy in the role of IDH mutations. Recent studies have identified subgroups within IDH wildtype and mutant chondrosarcomas, which should be further studied to improve treatment and predictive biomarkers.
Meeting Abstract
Oncology
Danh D. Truong, Salah-Eddine Lamhamedi-Cherradi, Mayinuer Maitituoheti, Hannah C. Beird, Chia-Chin Wu, Sandhya Krishnan, Davis Ingram, P. Andrew Futreal, Mark Titus, Alexander Lazar, Kunal Rai, A. Robert MacLeod, Najat C. Daw, Andrea Hayes, Joseph Ludwig
Meeting Abstract
Medicine, Research & Experimental
Rossana Lazcano, Davis Ingram, Alexander Lazar, Wei-Lien (Billy) Wang, Jeffrey Cloutier
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Rossana Lazcano, Raymond Traweek, Davis Ingram, Khalida Wani, B. Ashleigh Guadagnolo, Ahsan Farooqi, Christina Roland, Emily Keung, Andrew Bishop, Wei-Lien (Billy) Wang, Elise Nassif, Alexander Lazar
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Sintawat Wangsiricharoen, Davis Ingram, Alexander Lazar, Wei-Lien (Billy) Wang
LABORATORY INVESTIGATION
(2023)
Article
Physiology
Ramzi Khalil, Josephine D. D. Bonnemaijer, Reinhold Kreutz, Herman P. Spaink, Pancras C. W. Hogendoorn, Hans J. Baelde
Summary: Transmembrane protein 14A (TMEM14A) is an important protein involved in maintaining the integrity of the glomerular filtration barrier. It suppresses Bax-mediated apoptosis and its expression is increased in proteinuric renal diseases.
PHYSIOLOGICAL REPORTS
(2023)
Review
Immunology
Marloes M. A. R. van Dorst, Jeremia J. Pyuza, Gyaviira Nkurunungi, Vesla I. Kullaya, Hermelijn H. Smits, Pancras C. W. Hogendoorn, Linda J. Wammes, Bart Everts, Alison M. Elliott, Simon P. Jochems, Maria Yazdanbakhsh
Summary: There is considerable variation in efficacy of vaccines across populations and geographical regions, which is influenced by multiple environmental factors. Current interventions targeting these factors have had variable success, highlighting the need for a better understanding of the immunological mechanisms involved in vaccine responses.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.
