期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 16, 期 15, 页码 1230-1243出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557516666160505115743
关键词
Cancer; COX-2; Cyclooxygenase; Inflammation; Oncology; PGE2
资金
- Open Project Program of State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences [Y412201442]
- National Natural Science Fund [31300643]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Cancer is a major cause of death worldwide despite significant advances in surgery and biology. Several recent studies have suggested that there is a close connection between tumorigenesis and inflammation. Cyclooxygenase-2 (COX-2), a link between inflammation and cancer, was proposed as a prime target for cancer therapy. However, the main available COX-2 inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), have several side effects that limit their application in cancer treatment. Additional research is needed to identify drugs that can regulate COX-2 or prostaglandin E2 (PGE2) with greater efficacy. Understanding the mechanism of COX-2/PGE2-mediated cancer and inflammation would be very useful for successful drug development. Progress of research and development into the role of COX related signaling both in inflammation and tumorigenesis in recent years has been summarized and introduced in this paper. Novel drugs designed to inhibit COX-2-related cancers are discussed to provide references for further development of novel drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据