Article
Pharmacology & Pharmacy
Catarina Teixeira-Guedes, Ana Rita Bras, Ricardo G. Teixeira, Andreia Valente, Ana Preto
Summary: This study evaluated the anti-cancer properties and mechanisms of action of ruthenium complexes in the treatment of colorectal cancer (CRC). The complexes displayed high bioactivity by reducing cell proliferation, inducing cell cycle arrest, increasing apoptosis, and inhibiting MEK/ERK and PI3K/AKT signaling pathways. The complexes also decreased cellular clonogenic ability and cell migration by disrupting F-actin cytoskeleton integrity, making them promising as a new therapeutic strategy for CRC treatment.
Article
Biochemistry & Molecular Biology
Damiano Cirri, Tiziano Marzo, Iogann Tolbatov, Alessandro Marrone, Francesco Saladini, Ilaria Vicenti, Filippo Dragoni, Adele Boccuto, Luigi Messori
Summary: Certain metal compounds have shown significant antiviral properties with acceptable cytotoxicity, potentially impacting nucleophile sites in the proteins or nucleobase strands of SARS-CoV-2 through metalation. Only deprotonated Cys and Sec residues can react favorably with these metallodrugs.
Article
Biochemistry & Molecular Biology
Sindhu G. Nair, Ahmed F. El-Yazbi, Amira F. El-Yazbi
Summary: In this study, we investigated the molecular mechanism of a ruthenium complex in inducing DNA damage using a simple, sensitive, and multiplexed assay. Our results showed that the complex induced significant damage at specific sites, with the extent of damage increasing with the number of guanines. We also confirmed the interaction between the complex and DNA using thermal analysis and MALDI-TOF-MS. Furthermore, we successfully applied our method to determine the potency of the complex in inducing DNA damage in K-Ras and N-Ras genes, which are commonly involved in cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Inorganic & Nuclear
Cristiane F. A. Teixeira, Estefane I. Teixeira, J. P. C. Nascimento, M. Amilcar Junior, L. M. C. Pinto, Anderson R. L. Caires, G. B. Alcantara, Ana C. Micheletti, Victor M. Deflon, Davi F. Back, Heveline Silva, Lucas Pizzuti, Gleison Antonio Casagrande
Summary: Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE/thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. These complexes exhibited similar structural behavior around the Copper(I) atoms and showed promising antimicrobial and anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Biochemistry & Molecular Biology
Rone Aparecido De Grandis, Analu Rocha Costa, Carlos Andre Ferreira Moraes, Natalia Zaneti Sampaio, Igor Henrique Cerqueira, Wellington Garcia Marques, Adriana Pereira Mundin Guedes, Joao Honorato de Araujo-Neto, Fernando Rogerio Pavan, Felipe Cerqueira Demidoff, Chaquip Daher Netto, Alzir Azevedo Batista, Flavia Aparecida Resende
Summary: In this study, two new Ru(II)/bipyridine/phenanthroline complexes containing lapachol as ligand were synthesized and tested for cytotoxicity against cancer cells. The results showed that one of the complexes exhibited selective toxicity against various cancer cells, which was related to the increase in reactive oxygen species and its potential binding to DNA. The findings contribute to the understanding of the anti-cancer potential and toxicological events of these new ruthenium complexes.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Srividya Swaminathan, Rajasekharan Jayakumari Deepak, Ramasamy Karvembu
Summary: The field of bioorganometallic chemistry has seen significant expansion in recent years, particularly in the development of efficient catalysts and anticancer drugs using organometallic complexes. The properties and processes of these complexes, particularly those of ruthenium(II) and osmium(II), rely on electronic and steric factors. These complexes have been widely used as versatile precursors in biological and catalytic applications. By indirectly affecting cellular redox homeostasis through catalytic transfer hydrogenation, they have shown promise in anticancer therapy.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Oncology
Sabyasachi Banerjee, Subhasis Banerjee
Summary: Metal-based therapy, especially platinum complexes, has become a significant approach in treating cancer. Advances in the understanding of biomolecular mechanisms have led to the development of non-classical platinum-based complexes with different mechanisms of action. The synthesis of new metal-based complexes with improved cytotoxicity and safety profiles has also been a focus. Several agents are currently in clinical trials or awaiting regulatory approval.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Evgeny K. Apartsin, Nadezhda Knauer, Ulf Dietrich Kahlert, Anne-Marie Caminade
Summary: Dendritic molecules with metal complexes are potential therapeutic entities, and metallodendrons are particularly of interest as antitumor agents. In this study, we synthesized amphiphilic metallodendrons and tested their antitumor activity against glioblastoma. The results showed that the metallodendrons exhibited higher cytotoxic activity compared to the clinical standard of care for glioblastoma, indicating their potential as antitumor entities.
Correction
Chemistry, Inorganic & Nuclear
Jiahe Li, Zhiyuan Wang, Zhongting Chen, Xingyong Xue, Kejuan Lin, Hailan Chen, Lixia Pan, Yulin Yuan, Zhen Ma
Summary: The correction provides revised information on the crystal structure, photoluminescence, and DNA interactions of silver complexes with substituted terpyridines, which show potential as anticancer metallodrugs.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Liqiang Wang, Bin Huang, Xuemin Duan, Guijuan Jiang, Yanshi Xiong, Shengfei Zhong, Jintao Wang, Xiangwen Liao
Summary: New ruthenium complexes were synthesized and found to have significant antimicrobial activity against Staphylococcus aureus, with Ru(II)-3 being the most effective, increasing susceptibility to common antibiotics and showing low resistance even after 20 passages. Additionally, Ru(II)-3 efficiently inhibited biofilm formation and toxin secretion of Staphylococcus aureus, indicating its potential as a novel antimicrobial agent.
JOURNAL OF CHEMICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Jose C. Paez-Franco, Miriam R. Zermeno-Ortega, Carmen Myriam de la O-contreras, Daniel Canseco-Gonzalez, Jesus R. Parra-Unda, Alcives Avila-Sorrosa, Raul G. Enriquez, Juan M. German-Acacio, David Morales-Morales
Summary: Fluorination of pharmaceutical agents is crucial for modifying their pharmacological profiles and addressing the limitations of metallodrugs, ultimately enhancing their potential anticancer activity.
Article
Chemistry, Medicinal
Zohaib Rana, Sarah Diermeier, Fearghal P. Walsh, Muhammad Hanif, Christian G. Hartinger, Rhonda J. Rosengren
Summary: The novel HDAC inhibitors Jazz90 and Jazz167 showed higher cancer-cell selectivity and anti-angiogenic effects in metastatic castration-resistant prostate cancer cells compared to SAHA, with no toxicity observed in mice, indicating potential for further in vivo studies.
Review
Chemistry, Medicinal
Tiziano Marzo, Diego La Mendola
Summary: Angiogenesis is a crucial process for tissue and organ function and growth, controlled by complex mechanisms involving metal ions. Some heavier metal ion complexes are used as anticancer agents, affecting angiogenic mechanisms. Understanding the interaction between metal ions and angiogenesis may provide insights for developing new inorganic drugs to combat resistance and recurrence in cancer treatment.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Klaudia Cseh, Heiko Geisler, Kristina Stanojkovska, Julia Westermayr, Philipp Brunmayr, Dominik Wenisch, Natalie Gajic, Michaela Hejl, Martin Schaier, Gunda Koellensperger, Michael A. A. Jakupec, Philipp Marquetand, Wolfgang Kandioller
Summary: The main purpose of this study was to synthesize a new set of naphthoquinone-based ruthenium(II) arene complexes and understand their mode of action. The chemical structures and biological activities of these compounds were examined, and a positive correlation was found between cytotoxicity, lipophilicity, and cellular accumulation. This study provides important insights into the effects of these arene complexes.
Article
Biochemistry & Molecular Biology
Brandon Putterill, Charles Rono, Banothile Makhubela, Debra Meyer, Ntombenhle Gama
Summary: Infection by human immunodeficiency virus is a major global health challenge and the use of combination antiretroviral therapy has been successful. However, the associated side effects of these drugs necessitate the development of new treatment strategies. This study investigated metal-based complexes with anticancer activity for their potential in inhibiting viral entry. The complexes showed significant inhibition at low concentrations and were non-toxic to mammalian cells. In silico docking analysis indicated that the interaction with the CCR5 co-receptor may be the mechanism of action.
Article
Biochemistry & Molecular Biology
Irshad Ahmad, Swati Sharma, Neha Gupta, Qudsia Rashid, Mohammad Abid, Mohammad Z. Ashraf, Mohamad Aman Jairajpuri
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Chemistry, Multidisciplinary
Farooq Ahmad Wani, Amaduddin, Babita Aneja, Gerard Sheehan, Kevin Kavanagh, Rabia Ahmad, Mohammad Abid, Rajan Patel
Article
Chemistry, Multidisciplinary
Saigal, Mohammad Irfan, Parvez Khan, Mohammad Abid, Md Musawwer Khan
Article
Biochemistry & Molecular Biology
Bhumika Kumar, Sonia Verma, Mohammad Kashif, Ruby Sharma, Atul, Rajnikant Dixit, Agam P. Singh, Veena Pande, Ajay K. Saxena, Mohammad Abid, Kailash C. Pandey
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Review
Chemistry, Medicinal
Mohammad Abid, Shailja Singh, Timothy J. Egan, Mukesh C. Joshi
Summary: Apicomplexian parasite Plasmodium is responsible for malaria, a devastating infectious disease. The emergence of drug-resistant strains has led to the need for new antimalarials. This review summarizes the structure-activity relationship (SAR) of metal-containing aminoquinolines and their potential as potent antimalarial drugs.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Shadabi Bano, Abdul Burhan Khan, Sana Fatima, Qudsia Rashid, Amresh Prakash, Neha Gupta, Irshad Ahmad, Shoyab Ansari, Andrew M. Lynn, Mohammad Abid, Mohamad Aman Jairajpuri
Summary: Thromboembolic diseases are a leading cause of death in humans, and the search for safer anticoagulants is highly desirable. In this study, a synthetic modified form of mannose, namely mannose 2,3,4,5,6-O-pentasulfate (MPS), was shown to have appreciable anticoagulation properties. The results indicate that MPS binds effectively to heparin-binding sites and enhances the activity of HCII, leading to prolonged clotting time.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Vikash Kumar, Rumaisha Shoaib, Ankita Behl, Akshay Munjal, Mohammad Abid, Shailja Singh
Summary: Malaria is a human disease caused by protozoan parasites. The study found that the prefoldin PFD6 interacts with the malaria parasite surface protein MSP-1, potentially playing a role in stabilizing or trafficking MSP-1.
Article
Biochemistry & Molecular Biology
Kashish Azeem, Mofieed Ahmed, Taj Mohammad, Amad Uddin, Anas Shamsi, Md. Imtaiyaz Hassan, Shailja Singh, Rajan Patel, Mohammad Abid
Summary: This study investigated the binding mechanism of hydroxychloroquine (HCQ) with human serum albumin (HSA) and its effect on the stability of HSA using various spectroscopic techniques and molecular dynamic simulation. The results confirmed the strong binding between HCQ and HSA, with involvement of van der Waals forces and hydrogen bonding. HCQ was found to affect the secondary structure of HSA. This research provides important insights into the physicochemical properties and interaction mechanism of HCQ with HSA.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Infectious Diseases
Iram Irfan, Asghar Ali, Bharati Reddi, Mohd Abrar Khan, Phool Hasan, Sarfraz Ahmed, Amad Uddin, Magdalena Piatek, Kevin Kavanagh, Qazi Mohd Rizwanul Haque, Shailja Singh, Anthony Addlagatta, Mohammad Abid
Summary: In this study, compound PS9 was identified as a potent and selective inhibitor of bacterial MetAPs. It exhibited antibacterial potential against Gram-positive and Gram-negative bacterial strains, and showed synergistic effects when combined with ampicillin and ciprofloxacin. PS9 also inhibited the growth of multidrug-resistant environmental isolates and showed no significant cytotoxic effect on human cells. The study suggests that PS9 could be a useful candidate for the development of antibacterial alternatives.
Article
Biochemistry & Molecular Biology
Iram Irfan, Asghar Ali, Ayesha Ubaid, Yeshfeen Sherwani, Bhoomika Arora, Md. Musawwer Khan, Mukesh C. Joshi, Mohammad Abid
Summary: A series of natural alcohols containing novel substituted cinnamates were developed and screened against five bacterial strains. Among them, YS17 showed 100% growth inhibition against all strains except for E. faecalis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Razia Sultana, Asghar Ali, Charmy Twala, Rabiya Mehandi, Manish Rana, Daraksha Yameen, Mohammad Abid, Rahisuddin
Summary: We synthesized pyrazole-bearing Schiff base derivatives (5a-5e) and (6a-6h) and confirmed their structures through various spectral analyses. The antibacterial activity of all analogs was tested, with lead analogs 5c and 6c showing potent activity against E. coli and B. subtilis. Further studies revealed groove binding mode of compounds 5c and 6c with CT-DNA, and their pharmacokinetic and ADME properties were calculated.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Analytical
Kashish Azeem, Mofieed Ahmed, Amad Uddin, Shailja Singh, Rajan Patel, Mohammad Abid
Summary: This study compared the interaction mechanisms between two potential antimalarial compounds and human serum albumin. Results showed that one of the compounds exhibited higher affinity and has a more favorable interaction with the protein.
Review
Microbiology
Asghar Ali, Andaleeb Zahra, Mohan Kamthan, Fohad Mabood Husain, Thamer Albalawi, Mohammad Zubair, Roba Alatawy, Mohammad Abid, Md Salik Noorani
Summary: This review explores the diverse applications of microbial biofilms, their clinical consequences, and alternative therapies targeting these resilient structures. The beneficial applications of microbial biofilms in wastewater treatment, bioremediation, food industries, agriculture, and biotechnology are discussed. The mechanisms of biofilm formation, clinical consequences of biofilms, and their association with antibiotic resistance, chronic infections, and medical device-related infections are highlighted. Furthermore, the potential of antimicrobial agents, such as antimicrobial peptides, quorum-sensing inhibitors, phytoextracts, and nanoparticles, in targeting biofilms is examined.
Article
Chemistry, Multidisciplinary
Farhat Habib, Asghar Ali, Iram Irfan, Amir Azam, Mohammad Abid, Imran Ali
Summary: In this study, a series of novel 1,2,4-oxadiazole-sulfonamide conjugates were synthesized and evaluated for their antimicrobial activity. Compound 8d showed significant inhibitory activity against both Gram-positive and Gram-negative bacterial strains, and exhibited synergistic effect with some antibiotics. It also demonstrated favorable drug-like characteristics and no toxicity towards human red blood cells.
Review
Biochemistry & Molecular Biology
Amad Uddin, Meenal Chawla, Iram Irfan, Shubhra Mahajan, Shailja Singh, Mohammad Abid
Summary: Resistance of traditional antimalarial drugs remains a challenge, leading to the search for novel lead molecules. Artemisinin-based combination therapy is the WHO-recommended first-line treatment, while hybrid molecules offer a new strategy for the development of next-generation antimalarial drugs.
RSC MEDICINAL CHEMISTRY
(2021)
