Targeted delivery of PROTAC-based prodrug activated by bond-cleavage bioorthogonal chemistry for microneedle-assisted cancer therapy

Metal-free bioorthogonal click chemistry in cancer theranostics

(2022) Dan Wu et al.   CHEMICAL SOCIETY REVIEWS

Rational Design for Nitroreductase (NTR)-Responsive Proteolysis Targeting Chimeras (PROTACs) Selectively Targeting Tumor Tissues

(2022) Shi Shi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enzyme-Catalyzed Activation of Pro-PROTAC for Cell-Selective Protein Degradation

(2022) Chunjing Liang et al.   CCS Chemistry

Targeting Undruggable Transcription Factors with PROTACs: Advances and Perspectives

(2022) Yan Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy

(2022) Jing Gao et al.   Nature Communications

Microneedle Patches with O 2 Propellant for Deeply and Fast Delivering Photosensitizers: Towards Improved Photodynamic Therapy

(2022) Pei Liu et al.   Advanced Science

Microneedle Patches Loaded with Nanovesicles for Glucose Transporter-Mediated Insulin Delivery

(2022) Qian Chen et al.   ACS Nano

RGD peptide modified platinum nanozyme Co-loaded glutathione-responsive prodrug nanoparticles for enhanced chemo-photodynamic bladder cancer therapy

(2022) Ying Hao et al.   BIOMATERIALS

Radiotherapy-Triggered Proteolysis Targeting Chimera Prodrug Activation in Tumors

(2022) Chunrong Yang et al.   Journal of the American Chemical Society

Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras

(2022) Thang Cong Do et al.   Science Advances

Efficacy of pH-Sensitive Nanomedicines in Tumors with Different c-MYC Expression Depends on the Intratumoral Activation Profile

(2021) Hitoshi Shibasaki et al.   ACS Nano

Microneedle-assisted genome editing: A transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders

(2021) Tao Wan et al.   Science Advances

Bioorthogonal catalytic patch

(2021) Zhaowei Chen et al.   Nature Nanotechnology

Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer

(2021) Shipeng He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General Strategy for Macrotheranostic Prodrug Activation: Synergy between the Acidic Tumor Microenvironment and Bioorthogonal Chemistry

(2020) Yansong Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PHOTACs enable optical control of protein degradation

(2020) Martin Reynders et al.   Science Advances

Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells

(2019) Shiyao Sui et al.   Cell Death & Disease

Light-Induced Protein Degradation with Photocaged PROTACs

(2019) Gang Xue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a Therapeutic and Diagnostic Target in Cancer

(2018) Kuojun Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hierarchical Tumor Microenvironment-Responsive Nanomedicine for Programmed Delivery of Chemotherapeutics

(2018) Sheng Wang et al.   ADVANCED MATERIALS

BRD4 and Cancer: going beyond transcriptional regulation

(2018) Benedetta Donati et al.   Molecular Cancer

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

(2016) Ester Jiménez-Moreno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small-Molecule PROTACS: New Approaches to Protein Degradation

(2016) Momar Toure et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Bioorthogonal Near-Infrared Fluorogenic Probe for mRNA Detection

(2016) Haoxing Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras

(2016) Honorine Lebraud et al.   ACS Central Science

Inverse electron demand Diels–Alder (iEDDA)-initiated conjugation: a (high) potential click chemistry scheme

(2013) Astrid-Caroline Knall et al.   CHEMICAL SOCIETY REVIEWS

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY