Article
Multidisciplinary Sciences
M. M. Yinhua Zhao, M. M. Yanyu Shi, Huang Lin
Summary: Recent studies suggest hypoxia promotes adipose-derived stem cells (ADSCs) to attenuate hypoxia/reoxygenation (H/R)-induced damage to human dermal microvascular endothelial cells (HDMECs). Extracellular vesicles (EVs) from ADSCs play a crucial role in regenerative medicine. This study investigated the effect of EVs from hypoxia-pretreated ADSCs on HDMECs and found that they effectively attenuate H/R-induced damage through autophagy activation and inhibiting apoptosis and oxidative stress.
Article
Cell Biology
Khushboo Goel, Erica L. Beatman, Nicholas Egersdorf, April Scruggs, Danting Cao, Evgeny V. Berdyshev, Kelly S. Schweitzer, Irina Petrache
Summary: The destruction of alveoli by cigarette smoke-induced apoptosis is a major factor in the development of emphysema. However, while lung endothelial cells from chronic smokers show increased resistance to apoptosis, their decreased expression of S1P1 may impair their autophagic response.
Article
Endocrinology & Metabolism
Haitao Zhang, Yan Shen, Il-man Kim, Neal L. Weintraub, Yaoliang Tang
Summary: Diabetes leads to abnormal cellular metabolism in CMECs, affecting glycolysis and mitochondrial oxidative phosphorylation, resulting in increased intracellular ROS levels. Gene expression and protein levels differ between diabetic and WT CMECs. Additionally, diabetic CMECs exhibit decreased cell proliferation and increased cellular apoptosis compared to WT CMECs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Zonghao Tang, Renfeng Xu, Zhenghong Zhang, Congjian Shi, Yan Zhang, Hongqin Yang, Qingqiang Lin, Yiping Liu, Fengping Lin, Baorong Geng, Zhengchao Wang
Summary: Hypoxia drives the activation of HIF-1 alpha/BNIP3 signaling, inducing an increase in autophagy, which protects GCs from apoptosis during follicular development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Wei He, Yu Fu, Song Yao, Lan Huang
Summary: The periodontal ligament consists of fibroblasts, cementoblasts, osteoblasts, osteoclasts, periodontal ligament stem cells (PDLSCs), and epithelial cell rests of Malassez. The regulation of programmed cell death is important for immune response but can also lead to the loss of periodontal supporting tissues and root resorption. These findings are relevant for understanding periodontitis and orthodontic root resorption. This comprehensive review focuses on recent studies on mechanisms of periodontal ligament cell death.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaojun Li, Zhenping Gui, Huizi Liu, Shaojie Qian, Yanan Jia, Xiaopan Luo
Summary: The study demonstrated that pretreatment with remifentanil (REM) ameliorated H/R-induced human cardiac microvascular endothelial cell (HCMEC) dysfunction by regulating the PI3K/Akt/HIF-1 alpha signaling pathway. REM enhanced cell viability, migratory abilities, and tube-like structure formations of H/R-stimulated HCMECs in a concentration-dependent manner, while also decreasing cell permeability and upregulating tight junction proteins expression. Inhibition of PI3K/Akt rescued REM-enhanced HCMEC function under H/R condition.
Article
Oncology
Carla Fourie, Manisha du Plessis, Justin Mills, Anna -Mart Engelbrecht
Summary: This study explores the role of HIF-1 alpha in breast cancer cells under hypoxic conditions and its impact on cell survival, apoptosis, and autophagy. The results suggest that targeting HIF-1 alpha may sensitize breast cancer cells to doxorubicin treatment and improve treatment responses. Silencing the HIF-1 alpha gene expression attenuates treatment resistance in a hypoxic environment.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Yanyan Wang, Marong Fang, Qiannan Ren, Wei Qi, Xinli Bai, Nashwa Amin, Xiangjian Zhang, Zhenzhong Li, Lihong Zhang
Summary: Intracranial aneurysm is a localized dilation of the intracranial arteries, and its rupture can be catastrophic. Hypertension mediates endothelial cell damage, which is a major risk factor for intracranial aneurysm. Sox17 is highly expressed in intracranial vascular endothelial cells and its genetic alteration is a major genetic risk factor for intracranial aneurysm. In this study, we found that knockdown of Sox17 worsened AngII-induced apoptosis and autophagy in human brain microvascular endothelial cells, while overexpression of Sox17 had the opposite effect.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Yan Wang, Yu Zhang, Jiao Li, Ranzun Zhao, Xianping Long, Chaofu Li, Weiwei Liu, Wenming Chen, Bei Shi
Summary: Mydgf can reduce apoptosis of cardiac microvascular endothelial cells (CMECs) induced by hypoxia/reoxygenation (HR) through regulating oxidative stress in endoplasmic reticulum stress (ERS).
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Review
Biochemistry & Molecular Biology
Moussa Omorou, Yiwei Huang, Meng Gao, Chenxi Mu, Weijing Xu, Yuchun Han, Hui Xu
Summary: Forkhead box O3 (FOXO3) is a protein encoded by the FOXO3 gene expressed throughout the body and could play a crucial role in longevity and various pathologies. This study comprehensively reviews the expression of FOXO3 under ischemia and reperfusion (IR) conditions and its molecular mechanisms. The expression level of FOXO3 is tissue-specific, with increased expression in lung and intestinal epithelial cells after IR but downregulation in the kidney after IR and skeletal muscles following ischemia. FOXO3 expression in the brain, liver, and heart following IR can be both increased and decreased, contributing to ischemia and reperfusion injury. Controlling FOXO3 expression genetically or pharmacologically may help prevent or treat IR damage.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qiuling Liu, Tujing Song, Bing Chen, Jingjing Zhang, Wen Li
Summary: Hypoxia is crucial for the development of various disorders, especially hypoxic cerebropathy. The damage to the blood-brain barrier (BBB) caused by hypoxia is well known. This study explored the correlation between endothelial ferroptosis and hypoxia-induced BBB damage using in vivo zebrafish and in vitro bEnd.3 cells. The results showed that hypoxic treatment could induce BBB disruption by down-regulating claudin-5 (CLDN5) expression in both zebrafish cerebrovascular endothelial cells and bEnd.3 cells.
Review
Geriatrics & Gerontology
Yuying Guan, Jia Liu, Yakun Gu, Xunming Ji
Summary: Cerebrovascular microcirculation is crucial for brain function, and angiogenesis plays a significant role in remodeling the microcirculation. Hypoxia is an important regulator of angiogenesis, but it also negatively affects cerebral vascular tissue. Establishing a model that promotes cerebral microvasculogenesis without causing injury is essential.
Article
Cardiac & Cardiovascular Systems
Sander Trenson, Hadewich Hermans, Sander Craps, Peter Pokreisz, Pauline de Zeeuw, Jore Van Wauwe, Hilde Gillijns, Denise Veltman, Fangfei Wei, Ellen Caluwe, Rik Gijsbers, Pieter Baatsen, Jan A. Staessen, Bart Ghesquiere, Peter Carmeliet, Filip Rega, Bart Meuris, Bart Meyns, Wouter Oosterlinck, Jurgen Duchenne, Kaatje Goetschalckx, Jens-Uwe Voigt, Marie-Christine Herregods, Paul Herijgers, Aernout Luttun, Stefan Janssens
Summary: The study revealed that pressure overload induces major transcriptional and metabolic adaptations in cardiac MiVEC, resulting in excessive interstitial fibrosis and impaired angiogenesis. Women with AS are more affected, with compromised functional status, and this identifies new targets for intervention.
CIRCULATION-HEART FAILURE
(2021)
Article
Pharmacology & Pharmacy
Qianlong Zhang, Yonggang Cao, Yongsheng Liu, Wei Huang, Jing Ren, Peng Wang, Chao Song, Kai Fan, Lina Ba, Lixin Wang, Hongli Sun
Summary: This study investigated the mechanism of shear stress in microvascular I/R injury and found that shear stress can reverse CMECs apoptosis and relieve microvascular injury by activating the YAP/miR-206/PDCD4 signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yang Liu, Guanlin Yang, Shiqiao Huo, Jiabi Wu, Ping Ren, Yonggang Cao, Jingquan Gao, Liquan Tong, Dongyu Min
Summary: This study found that lutein has a protective effect on cardiac microvascular endothelial cell ferroptosis induced by pressure overload in cardiac hypertrophy. Lutein supplementation increased interferon regulatory factor expression, providing protection and inhibiting ferroptosis by regulating solute carrier family 7 member 11 and glutathione peroxidase 4 expression. Therefore, targeting interferon regulatory factor may be a promising therapeutic strategy for effective cardioprotection in patients with cardiac hypertrophy and heart failure.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)