Review
Clinical Neurology
Konark Malhotra, Christina Zompola, Aikaterini Theodorou, Aristeidis H. Katsanos, Ashkan Shoamanesh, Himanshu Gupta, Simon Beshara, Nitin Goyal, Jason Chang, Ashis H. Tayal, Efstathios Boviatsis, Konstantinos Voumvourakis, Charlotte Cordonnier, David J. Werring, Andrei V. Alexandrov, Georgios Tsivgoulis
Summary: Among patients with spontaneous intracerebral hemorrhage, approximately 1 in 4 cases have undetermined etiology, leading to a relatively high short-term mortality rate. Cerebral amyloid angiopathy accounts for the largest hemorrhage volume, while hypertensive arteriopathy and undetermined ICH have smaller volumes.
Article
Neurosciences
Mengke Zhang, Ruiwen Che, Wenbo Zhao, Hailiang Sun, Changhong Ren, Jin Ma, Wenbo Hu, Milan Jia, Chuanjie Wu, Xin Liu, Xunming Ji
Summary: This study aimed to explore the relationship between computed tomography (CT)-based cerebral small vessel disease (SVD) markers and the clinical outcomes in patients with cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH). The results showed that the SVD markers based on CT could predict the short-term outcome more effectively in patients with CAA-ICH. Further studies are needed to validate these findings and identify modifiable factors for preventing CAA-ICH development.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Sabine Voigt, Siham Amlal, Emma A. Koemans, Ingeborg Rasing, Ellis S. van Etten, Erik W. van Zwet, Mark A. van Buchem, Gisela M. Terwindt, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: The study investigated the topographical and temporal patterns of index and recurrent intracerebral hemorrhages in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA). Results showed a preference for occipital lobe in both index and recurrent ICHs, with no acceleration in time nor gradual increase of hematoma volume between subsequent ICHs.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Aayushi Garg, Santiago Ortega-Gutierrez, Mudassir Farooqui, Nandakumar Nagaraja
Summary: This study found that patients with intracerebral hemorrhage (ICH) and concomitant cerebral amyloid angiopathy (CAA) are three times more likely to have readmissions for recurrent ICH compared to patients without CAA.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Howard Kirshner, Matthew Schrag
Summary: Intracerebral hemorrhage (ICH) accounts for 15% of all strokes in the US, yet almost 50% of fatal strokes. The most common causes are hypertension and cerebral amyloid angiopathy. Treatment focuses on managing edema, reducing blood pressure, and correcting coagulopathy. Current standard of care includes supportive therapies, but there is no definitive curative therapy like mechanical thrombectomy for ischemic stroke. New medical and surgical approaches show promise in improving ICH management.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Clinical Neurology
Yuyi Zhu, Lu Liu, Luyao Zhong, Yajun Cheng, Shihong Zhang, Bo Wu, Deren Wang, Mangmang Xu
Summary: The study aims to investigate the association between burden of cerebral small vessel disease (CSVD) caused by hypertensive angiopathy (HA) and cerebral amyloid angiopathy (CAA) on MRI in patients with primary intracerebral hemorrhage (ICH). The results showed a significant association between HA-CSVD and CAA-CSVD, which needs to be confirmed in future studies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Simon Fandler-Hoefler, Thomas Gattringer, Christian Enzinger, David J. Werring
Summary: This study found that patients with probable CAA who were diagnosed using the Boston v2.0 criteria had a lower risk of ICH recurrence compared to those diagnosed using the v1.5 criteria.
Article
Clinical Neurology
Evangelos Pavlos Myserlis, Christopher D. Anderson, Marios K. Georgakis
Summary: Recent evidence suggests that higher CRP levels are associated with lower risk of Alzheimer disease, and this study explores whether genetically proxied CRP levels are also associated with lobar intracerebral hemorrhage (ICH) caused by cerebral amyloid angiopathy. The results show that higher genetically proxied CRP levels are associated with lower odds of lobar ICH, supporting the hypothesis that high CRP levels may have a protective role in amyloid-related pathology.
Article
Medicine, General & Internal
Russell P. Sawyer, Stacie L. Demel, Mary E. Comeau, Miranda Marion, Jonathan Rosand, Carl D. Langefeld, Daniel Woo
Summary: Apolipoprotein E alleles are associated with both Alzheimer's disease and intracerebral hemorrhage; intracerebral hemorrhage has a high risk of subsequent dementia; variations in CR1 and CLU genes are associated with an increased risk of lobar ICH.
Article
Clinical Neurology
Joan Marti-Fabregas, Pol G. Camps-Renom, Jonathan G. Best, Anna Ramos-Pachon, Marina Guasch-Jimenez, Alejandro Martinez-Domeno, Daniel M. Guisado-Alonso, Beatriz M. Gomez-Anson, Gareth Ambler, Duncan Wilson, Keon-Joo Lee, Jae-Sung Lim, Hee-Joon Bae, Masayuki Shiozawa, Masatoshi Koga, Kazunori G. Toyoda, Michael G. Hennerici, Hugues Chabriat, Eric Jouvent, Debbie Yuen Kwun Wong, Henry Mak, Kui Kai Lau, Young Dae Kim, Tae-Jin Song, Ji-Hoe Heo, Sebastian Eppinger, Thomas Gattringer, Ender Uysal, Derya Selcuk Demirelli, Natan Bornstein, Einor Ben Assayag, Hen A. Hallevi, Jeremy A. Molad, Masashi Nishihara, Jun Tanaka, Hideo Hara, Yusuke B. Yakushiji, Shelagh B. Coutts, Eric A. Smith, Alexandros A. Polymeris, Benjamin Wagner, David A. Seiffge, Philippe A. Lyrer, Nils T. Peters, Stefan T. Engelter, Rustam Al-Shahi Salman, Hans Rudolf Jager, Gregory Y. H. Lip, Martina Goeldlin, Leonidas Panos, Christopher Charles G. Karayiannis, Thanh G. K. Phan, Velandai K. Srikanth, Nicolas Christ, Sarah Gunkel, Felix W. Fluri, Thomas W. Leung, Yannie O. Y. Soo, Winnie Chu, Jill Abrigo, Carmen Barbato, Simone Browning, Robert Simister, Anne-Marie Mendyk, Regis Bordet, Saima Hilal, Bibek Gyanwali, Christopher Chen, Simon Jung, Dilek Necioglu Orken, David Werring, Luis Prats-Sanchez
Summary: This study aimed to investigate the risk of future cerebrovascular events in patients with ischemic stroke (IS) or transient ischemic attack (TIA) and cortical superficial siderosis (cSS), as well as the benefits and safety of antithrombotic drugs for secondary prevention. The study found that cSS was associated with an increased risk of stroke, and the risk of IS was higher than that of intracranial hemorrhage (ICrH) in patients receiving antiplatelet or anticoagulant treatment alone, while the risk of ICrH was higher than that of IS in patients receiving both treatments. Therefore, the study suggests that using antiplatelet or anticoagulant drugs alone is safe in patients with cSS, but combined antithrombotic therapy might be hazardous.
Article
Clinical Neurology
Giuseppe Scopelliti, Barbara Casolla, Gregoire Boulouis, Gregory Kuchcinski, Solene Moulin, Didier Leys, Hilde Henon, Charlotte Cordonnier, Marco Pasi
Summary: Anxiety is common among survivors of spontaneous intracerebral hemorrhage (ICH), often occurring together with depressive symptoms even years after the initial event. Lobar ICH location is significantly associated with anxiety 1-2 years after ICH.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Review
Clinical Neurology
Mangmang Xu, Yuyi Zhu, Xindi Song, Xuelian Zhong, Xinxin Yu, Deren Wang, Yajun Cheng, Wendan Tao, Bo Wu, Ming Liu
Summary: In this systematic review and meta-analysis, we investigated the relationship between cerebral amyloid angiopathy (CAA) and arteriolosclerosis in intracerebral hemorrhage (ICH) patients. We also compared the MRI and pathological changes of markers of cerebral small vessel disease (CSVD). The results indicated that severe CAA was potentially associated with arteriolosclerosis. Patients with evidence of CAA had a higher number of microbleeds compared to those without CAA. However, further research is needed to explore the pathological changes of CSVD markers according to the etiology of ICH.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Medicine, General & Internal
Carmen Barbato, Piergiuseppe Liuzzi, Anna Maria Romoli, Francesca Draghi, Daniela Maccanti, Andrea Mannini, Claudio Macchi, Francesca Cecchi, Bahia Hakiki
Summary: This study found that sporadic CAA associated with cerebral hemorrhage is independently associated with poorer rehabilitation outcomes, regardless of age. This suggests the importance of improving knowledge about CAA to better predict rehabilitation outcomes.
Review
Clinical Neurology
Xinglei Jia, Menghan Bo, Hong Zhao, Jia Xu, Luqian Pan, Zhengyu Lu
Summary: Cerebral amyloid angiopathy (CAA) related intracerebral hemorrhage (ICH) has a high recurrence rate, and risk factors associated with recurrence include previous ICH, baseline ICH volume, subarachnoid hemorrhage, cortical superficial siderosis, disseminated cortical superficial siderosis, and centrum semiovale-perivascular spaces severity.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Mingxu Xia, Ya Su, Jiayu Fu, Jiajie Xu, Qiong Wang, Feng Gao, Yong Shen, Qiang Dong, Xin Cheng
Summary: This study found that serum MMP-2 levels in the acute phase may serve as a promising biomarker to predict CAA-ICH recurrence and evaluate the risk of cognitive impairment. Additionally, higher levels of MMP-2 were associated with cerebral microbleeds count and MRI burden score.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Dermatology
Alexis Kelly, Alexander Pai, Ben Lertsakdadet, Bernard Choi, Kristen M. Kelly
LASERS IN SURGERY AND MEDICINE
(2020)
Article
Nanoscience & Nanotechnology
Wangcun Jia, Joshua M. Burns, Betty Villantay, Jack C. Tang, Raviraj Vankayala, Ben Lertsakdadet, Bernard Choi, J. Stuart Nelson, Bahman Anvari
ACS APPLIED MATERIALS & INTERFACES
(2020)
Editorial Material
Engineering, Biomedical
John A. White, Donald P. Gaver, Robert J. Butera, Bernard Choi, Mary J. Dunlop, K. Jane Grande-Allen, Anna Grosberg, Robert W. Hitchcock, Aileen Y. Huang-Saad, Miiri Kotche, Aaron M. Kyle, Amy L. Lerner, John H. Linehan, Robert A. Linsenmeier, Michael I. Miller, Jason A. Papin, Lori Setton, Allyson Sgro, Michael L. Smith, Muhammad Zaman, Abraham P. Lee
ANNALS OF BIOMEDICAL ENGINEERING
(2020)
Article
Cardiac & Cardiovascular Systems
Christian Crouzet, Robert H. Wilson, Donald Lee, Afsheen Bazrafkan, Bruce J. Tromberg, Yama Akbari, Bernard Choi
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Biochemical Research Methods
Evelyn M. Hoover, Christian Crouzet, Julianna M. Bordas, Dario X. Figueroa Velez, Sunil P. Gandhi, Bernard Choi, Melissa B. Lodoen
Summary: The CAS technique is a minimally invasive surgical technique that allows long-term cerebral blood flow imaging through the intact mouse skull. With CAS, researchers can observe cerebral blood flow dynamics, measure cerebral blood flow stably, and investigate potential therapeutic effects of modifying cerebral blood flow in mouse models relevant to human disease.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Neurosciences
Bernard Choi, Christian Crouzet, Wei Ling Lau, David H. Cribbs, Mark J. Fisher
Summary: The prevalence of mild cognitive impairment increases with age and is exacerbated by chronic kidney disease (CKD). CKD is associated with various impairments in cerebral microvasculature and brain health. Preliminary findings suggest that altered kidney function can lead to changes in cerebrovascular reactivity in CKD, affecting cerebral blood flow and potentially cognitive function.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Neurosciences
Katiana Khouri, Danny F. Xie, Christian Crouzet, Adrian W. Bahani, David H. Cribbs, Mark J. Fisher, Bernard Choi
Summary: The study presents a two-day protocol combining perfusion-based labeling with a clearing step to visualize and characterize the three-dimensional microvasculature in the whole brain. By using retro-orbital injection and light-sheet microscopy, sharp visualization of cerebral microvasculature throughout the intact mouse brain is achieved.
Article
Neurosciences
Robert H. Wilson, Christian Crouzet, Mohammad Torabzadeh, Afsheen Bazrafkan, Niki Maki, Bruce J. Tromberg, Yama Akbari, Bernard Choi
Summary: This study demonstrates a multimodal technique for measuring absolute CMRO2 in the rodent brain. By using laser speckle imaging and spatial frequency domain imaging to obtain spatiotemporal maps of cerebral blood flow, tissue absorption, and tissue scattering, combined with a mathematical model, absolute CMRO2 values can be calculated. The results obtained with this method in a rat model of cardiac arrest are consistent with those obtained through magnetic resonance and positron emission tomography.
Article
Critical Care Medicine
Ben S. Lertsakdadet, Gordon T. Kennedy, Randolph Stone, Christine Kowalczewski, Andrew C. Kowalczewski, Shanmugasundaram Natesan, Robert J. Christy, Anthony J. Durkin, Bernard Choi
Summary: The study demonstrates that blood-flow measurements with LSI can serve as an appropriate strategy for accurately assessing burn severity, even in a dynamic burn wound environment.
Article
Multidisciplinary Sciences
Christian Crouzet, Gwangjin Jeong, Rachel H. Chae, Krystal T. LoPresti, Cody E. Dunn, Danny F. Xie, Chiagoziem Agu, Chuo Fang, Ane C. F. Nunes, Wei Ling Lau, Sehwan Kim, David H. Cribbs, Mark Fisher, Bernard Choi
Summary: This study compared three digital pathology approaches for identifying and quantifying CMHs from Prussian blue-stained brain sections. Deep learning and ratiometric approaches outperformed phasor analysis, with deep learning showing the highest precision and ratiometric approach exhibiting the most versatility while maintaining accuracy.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Sangwoo Han, Mayra Isabel Contreras, Afsheen Bazrafkan, Masih Rafi, Shirin M. Dara, Ani Orujyan, Anais Panossian, Christian Crouzet, Beth Lopour, Bernard Choi, Robert H. Wilson, Yama Akbari
Summary: This study explored the role of anoxic spreading depolarizations (SD) in cerebral hemodynamics and metabolism, peripheral blood pressure, and the relationship between these variables in rats. The results showed decoupling of peripheral blood pressure from cerebral blood flow and metabolism during anoxic SD, possible modification of cerebrovascular resistance by anoxic SD, and a correlation between shorter time differences between anoxic SDs and better neurological outcomes.
NEUROCRITICAL CARE
(2022)
Article
Neurosciences
Pil-Jong Kim, Hyun-Tae Kim, Bernard Choi, Teo Jeon Shin
Summary: Sedation is commonly used to relieve fear and anxiety during procedures. This study investigated the altered network connection during dexmedetomidine (DEX)-induced sedation using graph theory. The results showed that the brain network during DEX-induced sedation exhibited a transition towards random behavior and significant disturbances in the alpha frequency band, suggesting a relationship between changes in brain network critical to cognition and the mechanism of sedation.
NEUROSCIENCE LETTERS
(2023)
Review
Neurosciences
Christian Crouzet, Thinh Phan, Robert H. Wilson, Teo Jeon Shin, Bernard Choi
Summary: The complex cerebrovascular network plays a critical role in regulating local cerebral blood flow and maintaining brain balance. Disorders like Alzheimer's disease and neurological injury disrupt this regulation, leading to impaired brain balance. In rodents, studying cortical hemodynamic changes using widefield optical imaging approaches can provide insights into these complex dynamics. These approaches can measure hemodynamic information like blood flow and oxygenation over a wide range of brain tissue depth, improving our understanding of cerebrovascular mechanisms in AD and neurological injury.
Proceedings Paper
Optics
Yuto Shimada, Kazuki Takada, Hoang Son Nam, Kakeru Miyazaki, Keita Yasutomi, Shoji Kawahito, Christian Crouzet, Bernard Choi, Gordon T. Kennedy, Anthony J. Durkin, Keiichiro Kagawa
Summary: In this study, a method combining multi-band spatial frequency domain imaging (SFDI) and multi-exposure laser speckle contrast imaging (MELSCI) with a laboratory-designed CMOS image sensor was developed for simultaneous multi-modal imaging to improve the accuracy of medical diagnosis.
DESIGN AND QUALITY FOR BIOMEDICAL TECHNOLOGIES XV
(2022)
Review
Anesthesiology
Teo Jeon Shin, Pil-Jong Kim, Bernard Choi
Summary: General anesthesia is crucial for medical procedures, but the exact mechanisms of anesthetics are still not well understood. Mathematical models can provide insights into the dynamics of neuronal connectivity and help study the mechanisms of action of anesthetics.
KOREAN JOURNAL OF ANESTHESIOLOGY
(2022)
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)