Inhibition of lysosome-tethered Ragulator-Rag-3D complex restricts the replication of Enterovirus 71 and Coxsackie A16

Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection

(2022) Siwen Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel RIPK1 Inhibitor Reduces GVHD in Mice via a Non-immunosuppressive Mechanism that Restores Intestinal Homeostasis

(2022) Xiaoliang Yu et al.   BLOOD

Drug Repositioning for Hand, Foot, and Mouth Disease

(2022) Ran Yan et al.   Viruses-Basel

The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

(2021) Takeshi Nakatani et al.   Nature Communications

ANXA2 Facilitates Enterovirus 71 Infection by Interacting with 3D Polymerase and PI4KB to Assist the Assembly of Replication Organelles

(2021) Qiuhan Zhang et al.   VIROLOGICA SINICA

An infectious clone of enterovirus 71(EV71) that is capable of infecting neonatal immune competent mice without adaptive mutations

(2020) Huiying Zhang et al.   Emerging Microbes & Infections

Protecting the most vulnerable from hand, foot, and mouth disease

(2020) Yong Wah Tan et al.   LANCET INFECTIOUS DISEASES

ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB

(2019) Heyrhyoung Lyoo et al.   mBio

Viral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome Replication

(2019) Orly Laufman et al.   CELL

Bypassing pan-enterovirus host factor PLA2G16

(2019) Jim Baggen et al.   Nature Communications

Recent progress and challenges in drug development to fight hand, foot and mouth disease

(2019) Ze Qin Lim et al.   Expert Opinion on Drug Discovery

Bioorthogonal Metabolic Labeling Utilizing Protein Biosynthesis for Dynamic Visualization of Nonenveloped Enterovirus 71 Infection

(2019) Fangfang Wang et al.   ACS Applied Materials & Interfaces

Characterization of the c10orf76‐PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication

(2019) Jacob A McPhail et al.   EMBO REPORTS

An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease

(2018) Yong Wah Tan et al.   ANTIVIRAL RESEARCH

The life cycle of non-polio enteroviruses and how to target it

(2018) Jim Baggen et al.   NATURE REVIEWS MICROBIOLOGY

Enterovirus 3A Facilitates Viral Replication by Promoting Phosphatidylinositol 4-Kinase IIIβ–ACBD3 Interaction

(2017) Xia Xiao et al.   JOURNAL OF VIROLOGY

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

(2017) Ming-Yuan Su et al.   MOLECULAR CELL

Structural basis for the assembly of the Ragulator-Rag GTPase complex

(2017) Ryo Yonehara et al.   Nature Communications

Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane

(2017) Zongkai Mu et al.   Cell Discovery

BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication

(2016) Stefanie Morosky et al.   JOURNAL OF VIROLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Review of Enterovirus 71 Vaccines

(2014) P. Chong et al.   CLINICAL INFECTIOUS DISEASES

The late endosomal p14–MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration

(2014) Natalia Schiefermeier et al.   JOURNAL OF CELL BIOLOGY

Hand, foot, and mouth disease in China, 2008–12: an epidemiological study

(2014) Weijia Xing et al.   LANCET INFECTIOUS DISEASES

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: Evaluation of antiviral efficacy in a murine infection model

(2013) Xiaonan Zhang et al.   ANTIVIRAL RESEARCH

Caveolar Endocytosis Is Required for Human PSGL-1-Mediated Enterovirus 71 Infection

(2013) H.-Y. Lin et al.   JOURNAL OF VIROLOGY

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Echovirus 7 Entry into Polarized Intestinal Epithelial Cells Requires Clathrin and Rab7

(2012) C. Kim et al.   mBio

The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes

(2011) Yusuke Takahashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Non-Mouse-Adapted Enterovirus 71 (EV71) Strain Exhibits Neurotropism, Causing Neurological Manifestations in a Novel Mouse Model of EV71 Infection

(2011) W. X. Khong et al.   JOURNAL OF VIROLOGY

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Virology, epidemiology, pathogenesis, and control of enterovirus 71

(2010) Tom Solomon et al.   LANCET INFECTIOUS DISEASES

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK–ERK pathway to late endosomes

(2009) Shigeyki Nada et al.   EMBO JOURNAL

Scavenger receptor B2 is a cellular receptor for enterovirus 71

(2009) Seiya Yamayoshi et al.   NATURE MEDICINE

Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71

(2009) Yorihiro Nishimura et al.   NATURE MEDICINE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE