Direct visualization of immune status for tumor‐infiltrating lymphocytes by rolling circle amplification

MetaTiME integrates single-cell gene expression to characterize the meta-components of the tumor immune microenvironment

(2023) Yi Zhang et al.   Nature Communications

Modulating T Cell Responses by Targeting CD3

(2023) Ashwathi Puravankara Menon et al.   Cancers

Chromogenic Visualization of Single RNA Molecules In Situ with Duplex Capability by Rolling Circle Amplification with Alkaline Phosphatase

(2023) Ruolan Huang et al.   ANALYTICAL CHEMISTRY

Recent advances in biomaterial-boosted adoptive cell therapy

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Assessment of a Simplified Cell-Free DNA Method for Prenatal Down Syndrome Screening

(2022) Glenn E Palomaki et al.   CLINICAL CHEMISTRY

Clinical implications of T cell exhaustion for cancer immunotherapy

(2022) Andrew Chow et al.   Nature Reviews Clinical Oncology

Hierarchical DNA branch assembly-encoded fluorescent nanoladders for single-cell transcripts imaging

(2022) Xiaowen Cao et al.   NUCLEIC ACIDS RESEARCH

Beyond conventional immune-checkpoint inhibition — novel immunotherapies for renal cell carcinoma

(2021) David A. Braun et al.   Nature Reviews Clinical Oncology

Chemokines and the immune response to cancer

(2021) Aleksandra J. Ozga et al.   IMMUNITY

Evolution of systemic therapy for stages I–III non-metastatic non-small-cell lung cancer

(2021) Jamie E. Chaft et al.   Nature Reviews Clinical Oncology

Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes

(2021) Wantao Wu et al.   Journal of Hematology & Oncology

Immunotherapies for hepatocellular carcinoma

(2021) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

RNA-primed Amplification for Noise-suppressed Visualization of Single-cell Splice Variants

(2020) Xiaowen Cao et al.   ANALYTICAL CHEMISTRY

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

(2020) Yuanyuan Zhang et al.   Cellular & Molecular Immunology

Hybridization-based in situ sequencing (HybISS) for spatially resolved transcriptomics in human and mouse brain tissue

(2020) Daniel Gyllborg et al.   NUCLEIC ACIDS RESEARCH

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation

(2019) Wenjun Ouyang et al.   IMMUNITY

Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging

(2019) Ziming Du et al.   Nature Protocols

Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment

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Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

(2018) Xinyi Guo et al.   NATURE MEDICINE

SpliceRCA: in Situ Single-Cell Analysis of mRNA Splicing Variants

(2018) Xiaojun Ren et al.   ACS Central Science

DNA-Sequence-Encoded Rolling Circle Amplicon for Single-Cell RNA Imaging

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Flow cytometry: Surface markers and beyond

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Multispectral quantitative analysis of tumor-infiltrating lymphocyte (TIL) in triple negative breast cancer.

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Direct Visualization of Single-Nucleotide Variation in mtDNA Using a CRISPR/Cas9-Mediated Proximity Ligation Assay

(2018) Kaixiang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-cell transcriptomics to explore the immune system in health and disease

(2017) Michael J. T. Stubbington et al.   SCIENCE

Single-cell study of the extracellular matrix effect on cell growth by in situ imaging of gene expression

(2017) Yupeng Sun et al.   Chemical Science

Tumor-infiltrating lymphocytes (TILs) density as prognostic determinant in stage II colorectal cancer

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A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

(2016) Meromit Singer et al.   CELL

4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8+ T cell proliferation

(2016) Beom K Choi et al.   Cellular & Molecular Immunology

Highly Multiplexed Subcellular RNA Sequencing in Situ

(2014) J. H. Lee et al.   SCIENCE

In situ sequencing for RNA analysis in preserved tissue and cells

(2013) Rongqin Ke et al.   NATURE METHODS

In situ detection and genotyping of individual mRNA molecules

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Imaging individual mRNA molecules using multiple singly labeled probes

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