Article
Cell Biology
Leilei Xu, Zhenhua Feng, Zhicheng Dai, Wayne Y. W. Lee, Zhichong Wu, Zhen Liu, Xu Sun, Nelson Tang, Jack Chun-Yiu Cheng, Yong Qiu, Zezhang Zhu
Summary: This study found that rs1322330 in the promoter region of LBX1 is significantly associated with AIS in the Chinese population, potentially regulating myogenesis in the paraspinal muscles and contributing to the etiology of AIS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Chen He, Jian-Tao Yang, Qian Zheng, Zhao Mei, Christina Zong-Hao Ma
Summary: This study found that the Schroth exercise significantly improved the symmetry of the paraspinal muscles in patients with adolescent idiopathic scoliosis (AIS). Symmetry exercise further reduced the symmetry index, while asymmetric exercise increased the symmetry index. Among the four exercises, on all fours (exercise 1) and kneeling on one side (exercise 3) were the most and the least effective in improving symmetry, respectively. Squatting on the bar (exercise 2) and sitting with side bending (exercise 4) had the highest muscle activity on the concave and convex side, respectively.
BIOENGINEERING-BASEL
(2022)
Article
Genetics & Heredity
Piotr Janusz, Malgorzata Chmielewska, Miroslaw Andrusiewicz, Malgorzata Kotwicka, Tomasz Kotwicki
Summary: This study found that the severity of spinal curvature in IS patients may be associated with the methylation level of T-DMR2 in muscle tissue, and that DNA methylation of T-DMRs is specific to muscle tissue location. The methylation level is correlated with ESR1 expression level on the concave side, but not on the convex side.
Article
Orthopedics
Bahar Shahidi, Andrew Yoo, Christine Farnsworth, Peter O. Newton, Samuel R. Ward
Summary: This study compared paraspinal muscle microarchitecture and composition between concave and convex sides of scoliotic curves in AIS patients. It was found that muscle fibers were larger on the convex side of the curve, but muscles on both sides were atrophic compared to non-scoliotic individuals, with high levels of collagen observed.
Article
Medicine, General & Internal
Hong Jin Kim, Jae Hyuk Yang, Dong-Gune Chang, Se-Il Suk, Seung Woo Suh, Yunjin Nam, Sang-Il Kim, Kwang-Sup Song
Summary: Following posterior fusion surgery for adolescent idiopathic scoliosis, there are long-term changes in the volume of paraspinal muscles, with a significant increase in the psoas major muscle and decrease in the multifidus and erector spine muscles. It is crucial to minimize injury to the erector spine muscle to maintain development of the psoas major muscle.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Martin Simoneau, Jean-Philippe Pialasse, Pierre Mercier, Jean-Sebastien Blouin
Summary: This study aimed to investigate the neural control mechanisms of adolescent idiopathic scoliosis. The findings suggest that adolescents with idiopathic scoliosis exhibit increased variability in the timing of alpha oscillations in the control of axial muscles, which may be associated with spine deformation.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Orthopedics
Wai Kit Tam, Jason P. Y. Cheung, Paul A. Koljonen, Kenny Y. H. Kwan, Kenneth M. C. Cheung, Victor Y. L. Leung
Summary: This study found an association between abnormal HIF-2 alpha expression in paraspinal muscles and disproportionate slow twitch muscle fiber content in the concave musculature of AIS patients, suggesting HIF-2 alpha dysregulation as a possible risk factor for AIS.
Review
Genetics & Heredity
Duan Sun, Zihao Ding, Yong Hai, Yunzhong Cheng
Summary: Scoliosis, a three-dimensional deformity of the spine, is closely related to genetic, hormonal, and environmental factors. Epigenetic alterations in scoliosis have been studied but a comprehensive review is lacking. We analyzed 25 studies on DNA methylation, non-coding RNAs, histone modifications, and chromatin remodeling in scoliosis. DNA methylation and non-coding RNAs are well-researched, providing insights into prevention and treatment strategies. However, there is limited research on histone modifications and chromatin remodeling in scoliosis. Further exploration is needed to understand the overall effects of epigenetics in scoliosis.
FRONTIERS IN GENETICS
(2023)
Article
Clinical Neurology
Cesare Faldini, Francesca Barile, Fabrizio Perna, Stefano Pasini, Michele Fiore, Giovanni Viroli, Alberto Di Martino, Alberto Ruffilli
Summary: This article presents an original surgical technique for the treatment of rigid Adult Idiopathic Scoliosis (AdIS) and evaluates the results in a cohort of 40 patients. The surgical technique, Hi-PoAD, proved to be safe and effective in correcting spinal deformity and improving clinical outcomes.
EUROPEAN SPINE JOURNAL
(2021)
Article
Clinical Neurology
Zhen Wang, Xu'an Huang, Haining Tan, Jinqian Liang, Zheng Li, Jianxiong Shen
Summary: The study compares proteomic profiles of paraspinal muscle imbalance between idiopathic scoliosis (IS) and congenital scoliosis (CS). Samples of bilateral paraspinal muscles were collected from matched patients, and differentially expressed proteins (DEPs) were identified. Bioinformatic analyses showed that DEPs in IS were mainly enriched in calcium ion binding and DNA binding, while DEPs in CS were mainly enriched in receptor activity and immune response. Comparison of DEPs between IS and CS identified only a few shared proteins. Conclusion: IS and CS exhibit proteomic imbalance in paraspinal muscles, but there are limited similarities.
Article
Acoustics
Raphael Pietton, Mercedes David, Alisa Hisaund, Tristan Langlais, Wafa Skalli, Raphael Vialle, Claudio Vergari
Summary: The study aimed to investigate the use of shear-wave elastography to measure intercostal muscle shear-wave speed in healthy children and those with adolescent idiopathic scoliosis. Results showed that SWS was significantly higher during apnea in both groups compared to normal breathing, but no significant difference was observed between groups in apnea or in normal breathing.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Clinical Neurology
Zhichong Wu, Zhicheng Dai, Wang Yuwen, Zhen Liu, Yong Qiu, Jack Chun-Yiu Cheng, Zezhang Zhu, Leilei Xu
Summary: This study investigated the association of CHD7 with adolescent idiopathic scoliosis in Chinese Han population. The results showed that genetic variants of CHD7 were significantly associated with AIS, and the decreased expression of CHD7 may be involved in the abnormal bone mass of AIS patients. Further studies are needed to explore the functional role of CHD7 in the pathogenesis of AIS.
Article
Clinical Neurology
Benjamin Sherman, Peymon Madi, Afshin Aminian
Summary: The study found that performing thoracoplasty with posterior spinal fusion for adolescent idiopathic scoliosis did not increase immediate post-operative pain, narcotic use or oxygen consumption. Additionally, patients showed improved self-image scores after thoracoplasty.
EUROPEAN SPINE JOURNAL
(2021)
Review
Health Care Sciences & Services
Nicola Montemurro, Luca Ricciardi, Alba Scerrati, Giorgio Ippolito, Giorgio Lofrese, Sokol Trungu, Andrea Stoccoro
Summary: This study found that approximately 35.1% of individuals with 22q11.2 deletion syndrome develop scoliosis. By studying miRNAs in both 22q11.2DS and AIS, two shared miRNAs were identified, supporting the hypothesis of common molecular alterations in these two diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Jean-Francois Catanzariti, Alexandre Rimetz, Florence Genevieve, Gemma Renaud, Natacha Mounet
Summary: This study aims to verify the link between obesity and adolescent idiopathic scoliosis (AIS). By conducting X-ray measurements on obese adolescents, it was found that the prevalence of AIS in this population is twice as high as in the general population.
EUROPEAN SPINE JOURNAL
(2023)