Article
Chemistry, Multidisciplinary
Alessandro de Sire, Lorenzo Lippi, Claudio Curci, Dario Calafiore, Carlo Cisari, Antonio Ammendolia, Marco Invernizzi
Summary: The combination of ultrasound-guided RF ablation of genicular nerves and rehabilitative exercise therapy showed significant pain relief and improvement in functioning and HRQoL outcomes in KOA patients. Most patients had over 80% adherence to the exercise program, and no major adverse events were reported.
APPLIED SCIENCES-BASEL
(2021)
Article
Orthopedics
Chinchu Kolakkanni, Nitesh Manohar Gonnade, Ravi Gaur, Ashish Kumar Nayyar, Rambeer Ghuleliya, Abins Tk
Summary: In this study, the accuracy of ultrasound-guided bony landmarks in locating the superomedial, superolateral, and inferomedial genicular nerves was evaluated. The results showed that it is possible to perform radiofrequency ablation of these nerves with 100% accuracy using this method.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
A. Panagopoulos, P. Tsiplakos, K. Katsanos, P. Antzoulas, J. Lakoumentas
Summary: This study compares the efficacy, safety, and complications of cooled radiofrequency ablation (CRFA) and cryoneurolysis (CRYO) in relieving pain in symptomatic knee osteoarthritis (KOA). A prospective randomized trial will recruit 70 KOA patients, with 35 in the CRFA group and 35 in the CRYO group. The primary outcome is pain relief measured using the Numerical Rating Pain Scale (NRPS) at 2, 4, 12, and 24 weeks post-intervention.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Orthopedics
Jaspal R. Singh, Susie S. Kwon, Frank Schirripa, Behnum A. Habibi, Ethan Rand
Summary: Genicular nerve bipolar radiofrequency neurotomy (B-RFN) can improve pain and functional outcomes in chronic knee osteoarthritis (OA), but further research is needed to determine the appropriate patient population for this procedure.
Article
Medicine, General & Internal
Elsayed M. Elemam, Ola T. Abdel Dayem, Sherif A. Mousa, Hanaa M. Mohammed
Summary: This study compared the effectiveness of monopolar and bipolar radiofrequency ablation guided by ultrasound in treating chronic knee osteoarthritis pain. The results showed that bipolar ablation was more effective in reducing pain duration and severity, as well as improving VAS and OKS scores.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Anesthesiology
Zachary L. McCormick, Jaymin Patel, Aaron Conger, Clark C. Smith
Summary: Although genicular nerve radiofrequency ablation is generally considered safe, there have been reported cases of severe complications such as septic arthritis, tendon injuries, burns, and significant hematomas. As with any emerging procedure, there may be other complications that have not yet been reported.
Review
Rehabilitation
Alexandra E. Fogarty, Taylor Burnham, Keith Kuo, Quinn Tate, Beau P. Sperry, Cole Cheney, David R. Walega, Lynn Kohan, Steven P. Cohen, Daniel M. Cushman, Zachary L. McCormick, Aaron Conger
Summary: The objective of this study was to evaluate the effectiveness of fluoroscopically guided genicular nerve radiofrequency ablation for knee osteoarthritis. The results showed that radiofrequency ablation can provide significant pain relief after 6 months, with a higher probability of success compared to intra-articular steroid injection and hyaluronic acid injection. The treatment also improved the participants' Oxford Knee Score and Western Ontario and McMaster Universities Osteoarthritis Index scores. Based on the available evidence, fluoroscopically guided genicular nerve radiofrequency ablation is an effective treatment for reducing pain associated with knee osteoarthritis.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Anesthesiology
Omyma Shehata Mohamed, Sara Mohamed Omar, Alaa Fouli Gaber, Manal Mohamed Hassanien, Abd-Elraheem Mahmoud Mohamed
Summary: The study findings suggest that using the 3-needle technique for genicular nerve ablation in chronic knee osteoarthritis patients results in better efficacy and higher patient satisfaction compared to the single-needle technique.
Article
Anesthesiology
Amy Belba, Thibaut Vanneste, Sander M. J. Van Kuijk, Dieter Mesotten, Roel Mestrum, Koen Van Boxem, Astrid Van Lantschoot, Johan Bellemans, Marc Van de Velde, Jan Van Zundert
Summary: The study found that over 30% of patients with refractory knee pain achieved clinical success with radiofrequency treatment of the genicular nerves, with an average duration of effect of 8.3 months and good safety profile.
Article
Anesthesiology
Yi-Wei Chang, I-Shiang Tzeng, Kun-Chang Lee, Ming-Chang Kao
Summary: Ultrasound-guided genicular nerve radiofrequency ablation can significantly alleviate pain and improve functional outcomes in knee osteoarthritis patients. Static balance control and quadriceps muscle strength are preserved, and there is a change in proprioception.
Article
Anesthesiology
Jeffrey Lyman, Fred Khalouf, Keith Zora, Michael DePalma, Eric Loudermilk, Maged Guiguis, Douglas Beall, Lynn Kohan, Antonia F. Chen
Summary: This study assessed the long-term outcomes of cooled radiofrequency ablation for chronic knee pain due to osteoarthritis. The results showed that CRFA provided durable pain relief, improved function, and improved quality of life at 18 and 24 months post procedure.
Article
Anesthesiology
Marc Caragea, Tyler Woodworth, Tim Curtis, Michael Blatt, Cole Cheney, Todd Brown, Daniel Carson, Keith T. Kuo, Dustin Randall, Emily Y. Huang, Andrea Carefoot, Masaru Teramoto, Megan Mills, Amanda Cooper, Taylor Burnham, Aaron Conger, Zachary L. McCormick
Summary: In this study, it was found that approximately half of the patients experienced clinically meaningful improvements in knee pain after genicular nerve radiofrequency ablation (GNRFA). Factors associated with higher likelihood of treatment success included more advanced osteoarthritis, no use of opioids, antidepressants, or anxiolytics, and targeting more than 3 nerves.
Article
Anesthesiology
Amy Belba, Thibaut Vanneste, Ali Jerjir, Kristof Smeets, Jean-Pierre Van Buyten, Johan Bellemans, Jan Van Zundert
Summary: This case report highlights the development of CRPS in a chronic knee pain patient after RF ablation of the genicular nerves, which was successfully treated with DRG stimulation. Physicians should be aware of this potential complication, especially in patients with a history of CRPS.
Article
Oncology
Hui Zheng, Peicheng Li, Ruidong Ma, Feng Zhang, Hongxiu Ji, Wayne L. Monsky, Evan Johnson, Weizhu Yang, Caifang Ni, Dayong Gao, Xiaoming Yang
Summary: This study aims to develop an innovative three-dimensional, multi-modal, perfusion-thermal electrode system to address the problem of residual tumor cells and recurrence after thermal ablation treatment.
Article
Anesthesiology
Loic Fonkoue, Arnaud Steyaert, Jean-Eric K. Kouame, Eric Bandolo, Julien Lebleu, Hermann Fossoh, Catherine Behets, Christine Detrembleur, Olivier Cornu
Summary: This study compared the effectiveness of genicular nerve blockade using classical anatomical targets versus revised targets in patients with chronic knee osteoarthritis pain. The results showed that the revised targets group had a greater reduction in pain scores in the short term.