Article
Clinical Neurology
Yifan Yang, Ran Zhang, Zhifang Zhong, Jun Li, Yi Feng
Summary: Transauricular vagal nerve stimulation (taVNS) can effectively relieve chemotherapy-induced neuropathic pain in the short term, improve sleep status and quality of life in patients with CIPN, and is expected to become a novel clinical treatment method. However, the mechanism of taVNS in CIPN needs further investigation.
NEUROLOGICAL SCIENCES
(2023)
Review
Cell Biology
Giovanni Cirillo, Flor Negrete-Diaz, Daniela Yucuma, Assunta Virtuoso, Sohaib Ali Korai, Ciro De Luca, Eugenijus Kaniusas, Michele Papa, Fivos Panetsos
Summary: This paper provides a comprehensive overview of the pathogenesis and therapeutic approaches for inflammatory bowel diseases. The interaction between the enteric and central nervous systems and the role of the vagus nerve in autoimmune diseases are highlighted. Neuroprosthetic stimulation of the vagus nerve, particularly transcutaneous stimulation of the auricular branch, has been suggested as a potential therapeutic approach for controlling intestinal inflammation.
Article
Clinical Neurology
Jifei Sun, Chunlei Guo, Yue Ma, Shanshan Gao, Yi Luo, Qingyan Chen, Yang Hong, Xiaobing Hou, Xue Xiao, Xue Yu, Peijing Rong, Jiliang Fang
Summary: Previous studies have demonstrated the clinical efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in the treatment of major depressive disorder (MDD), and its mechanism of action involves the modulation of the default mode network (DMN) and cognitive control network (CCN). However, the immediate effect of taVNS on MDD is not well understood. This study aimed to investigate the immediate effect of taVNS on MDD and its impact on the DMN and CCN.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Chaoren Tan, Meng Qiao, Yue Ma, Yi Luo, Jiliang Fang, Yongsheng Yang
Summary: The study aimed to evaluate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) in treating depression. A total of 12 studies with 838 participants were included. The results showed that taVNS significantly improved depression and reduced Hamilton Depression Scale scores. Compared to sham-taVMS, taVNS had higher response rates and comparable efficacy to antidepressants (ATD), with fewer side effects. However, the number of studies was small and the evidence quality was low to very low. In conclusion, taVNS is an effective and safe method for alleviating depression scores and has a comparable response rate to ATD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Ittetsu Kin, Tatsuya Sasaki, Takao Yasuhara, Masahiro Kameda, Takashi Agari, Mihoko Okazaki, Kakeru Hosomoto, Yosuke Okazaki, Satoru Yabuno, Satoshi Kawauchi, Ken Kuwahara, Jun Morimoto, Kyohei Kin, Michiari Umakoshi, Yousuke Tomita, Naoki Tajiri, Cesario Borlongan, Isao Date
Summary: This study examined the efficacy of vagus nerve stimulation (VNS) on Parkinson's disease model rats using a wireless controllable electrical stimulator. The results showed that VNS with 0.25-0.5 mA intensity significantly improved behavioral impairment, preserved dopamine neurons, reduced inflammatory glial cells, and increased noradrenergic neurons. Further research confirmed the practicality and effectiveness of the new experimental device.
Article
Clinical Neurology
Kristina M. Deligiannidis, Thalia Robakis, Sarah C. Homitsky, Erona Ibroci, Bridget King, Sunu Jacob, Diana Coppola, Shane Raines, Konstantinos Alataris
Summary: The study suggests that the Nesos taVNS system may be an effective non-invasive, non-pharmacological treatment for major depressive disorder with peripartum onset. However, further evaluation in larger sham-controlled studies is needed.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Gastroenterology & Hepatology
Stephen J. Chapman, Jack A. Helliwell, Maureen Naylor, Cerys Tassinari, Neil Corrigan, David G. Jayne
Summary: This study demonstrates the safety, treatment compliance, and usability of self-administered nVNS in patients undergoing major colorectal surgery. The application of nVNS in patients undergoing colorectal surgery warrants further investigation.
COLORECTAL DISEASE
(2021)
Article
Multidisciplinary Sciences
Alice Courties, Jeremy Boussier, Jerome Hadjadj, Nader Yatim, Laura Barnabei, Helene Pere, David Veyer, Solen Kerneis, Nicolas Carlier, Frederic Pene, Frederic Rieux-Laucat, Bruno Charbit, Vincent Bondet, Darragh Duffy, Francis Berenbaum, Benjamin Terrier, Jeremie Sellam
Summary: The expression of cholinergic system members may be associated with COVID-19 severity and inflammatory response. The decreased expression of a negative dominant duplicate CHRFAM7A is correlated with COVID-19-induced hypercytokinemia.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Shuai Zhang, Jia-Kai He, Gang-Liang Zhong, Yu Wang, Ya-Nan Zhao, Lei Wang, Shao-Yuan Li, Xue Xiao, Zheng-Yi Yang, Bin Zhao, Jin-Ling Zhang, Tian-Zi Jiang, Ji-Liang Fang, Pei-Jing Rong
Summary: This study aimed to explore the modulating effect of prolonged longitudinal transcutaneous auricular vagus nerve stimulation (taVNS) on the striatal subregions' functional connectivity (FC) in major depressive disorder (MDD) patients. The results showed that some functional connectivity values changed after taVNS treatment in MDD patients compared to healthy controls.
Article
Clinical Neurology
Andreas Buchmann, Christopher Ritter, Sabrina Theresia Muller, Melanie Haynes, Carmen Ghisleni, Ruth Tuura, Gregor Hasler
Summary: Subjects with a history of major depressive episode (MDE) showed significantly reduced respiratory sinus arrhythmia (RSA) compared to those who never experienced depression. Higher RSA was associated with lower anxiety and fear levels, particularly in relation to cardiac symptoms and the fear of dying. Lower RSA was also linked to elevated levels of cytokines and thyroid-stimulating hormone in the serum, suggesting a potential connection between the immune system, vegetative nervous system, and emotional dysregulation.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, Research & Experimental
Shaoyuan Li, Peijing Rong, Yu Wang, Guixing Jin, Xiaobing Hou, Suxia Li, Xue Xiao, Wei Zhou, Yue Wu, Yaping Liu, Yue Zhang, Bin Zhao, Yiting Huang, Jin Cao, Helen Chen, Sierra Hodges, Mark Vangel, Jian Kong
Summary: The study found that transcutaneous auricular vagus nerve stimulation (taVNS) is as effective as the commonly used antidepressant citalopram in treating major depressive disorder. Furthermore, taVNS showed significantly higher remission rates at week four and week six compared to citalopram.
Article
Immunology
Zhen Qin, Kefa Xiang, Ding-Feng Su, Yang Sun, Xia Liu
Summary: This study suggests that activating the cholinergic anti-inflammatory pathway (CAP) may be a potential therapeutic strategy for COVID-19. Substances such as nicotine can activate the CAP and exert anti-inflammatory effects both in vitro and in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Supender Kaur, Nathan R. Selden, Alejandro Aballay
Summary: The neural control of the immune system is crucial for maintaining immune homeostasis, and disruption of this control may lead to various diseases. In this study, the impact of vagus nerve stimulation (VNS) on gene expression in peripheral blood mononuclear cells (PBMCs) was investigated. The results showed that VNS downregulated genes related to stress, inflammatory response, and immunity, suggesting its anti-inflammatory effect.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Sheng Li, Di Qi, Jia-ni Li, Xin-yu Deng, Dao-xin Wang
Summary: The cholinergic anti-inflammatory pathway regulates lung injury repair after ARDS through the STAT3 signaling pathway, with vagus nerve stimulation reducing TNF-alpha and IL-1 beta secretion, increasing IL-10 levels, and altering macrophage markers. VNS inhibits the ARDS inflammatory response by promoting CAIP activity, activating alpha 7nAchR and inducing changes in gene expression associated with inflammation and macrophage function.
CELL DEATH DISCOVERY
(2021)
Article
Psychiatry
Ronald G. Garcia, Justine E. Cohen, Arielle D. Stanford, Aileen Gabriel, Jessica Stowell, Harlyn Aizley, Riccardo Barbieri, David Gitlin, Vitaly Napadow, Jill M. Goldstein
Summary: The study aimed to evaluate the acute effects of a novel respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) technique on brain activity and connectivity in women with MDD in response to negative stressful stimuli. Results showed that exhalatory-gated RAVANS effectively modulated brain circuitries regulating response to negative stress and led to significant acute reduction of depressive and anxiety symptoms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
