Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2

Myofilament-associated proteins with intrinsic disorder (MAPIDs) and their resolution by computational modeling

(2023) Bin Sun et al.   QUARTERLY REVIEWS OF BIOPHYSICS

The role of alpha actinin paralogs in cardiac hypertrophy and contractile force production

(2023) Dylan T. Burnette et al.   BIOPHYSICAL JOURNAL

Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function

(2023) Maicon Landim-Vieira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2

(2023) Sophie Broadway-Stringer et al.   Cells

Nucleus Mechanosensing in Cardiomyocytes

(2023) Isabella Leite Coscarella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myofibril orientation as a metric for characterizing heart disease

(2022) Weikang Ma et al.   BIOPHYSICAL JOURNAL

ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes

(2022) Antonia T. L. Zech et al.   Cells

Titin force in muscle cells alters lattice order, thick and thin filament protein formation

(2022) Anthony L. Hessel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the native cardiac thin filament at systolic Ca2+ levels

(2021) Cristina M. Risi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction

(2021) Taejeong Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium

(2021) Weikang Ma et al.   CIRCULATION RESEARCH

Non-Canonical Interaction between Calmodulin and Calcineurin Contributes to the Differential Regulation of Plant-Derived Calmodulins on Calcineurin

(2021) Bin Sun et al.   Journal of Chemical Information and Modeling

Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms

(2021) Malene E. Lindholm et al.   Circulation-Genomic and Precision Medicine

Cardiac sarcomere mechanics in health and disease

(2021) Claudia Crocini et al.   Biophysical Reviews

Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin

(2020) Sandra Swist et al.   Nature Communications

Deletion of Enigma Homologue from the Z-disc slows tension development kinetics in mouse myocardium

(2019) Zachery R. Gregorich et al.   JOURNAL OF GENERAL PHYSIOLOGY

Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy

(2019) Maksymilian Prondzynski et al.   EMBO Molecular Medicine

The intrinsically disordered carboxy-terminus of troponin-T binds to troponin-C to modulate myocardial force generation

(2019) Jamie R. Johnston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2

(2019) Lawrence X. Cai et al.   Scientific Reports

Prognostic implications of left ventricular global longitudinal strain in patients with bicuspid aortic valve disease and preserved left ventricular ejection fraction

(2019) William K F Kong et al.   European Heart Journal-Cardiovascular Imaging

Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle

(2018) Weikang Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle

(2018) David Gonzalez-Martinez et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structure of isolated Z-disks from honeybee flight muscle

(2017) Mara Rusu et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

α-Actinin/titin interaction: A dynamic and mechanically stable cluster of bonds in the muscle Z-disk

(2017) Marco Grison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C

(2017) Tiago Veltri et al.   Scientific Reports

Global longitudinal strain is associated with heart failure outcomes in hypertrophic cardiomyopathy

(2016) Patricia Reant et al.   HEART

Why we need to understand the mechanics of developing cardiac sarcomeres in humans

(2016) R. John Solaro   JOURNAL OF PHYSIOLOGY-LONDON

Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2016) Josè Manuel Pioner et al.   Stem Cell Reports

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

The non-muscle functions of actinins: an update

(2014) Kate S. Foley et al.   BIOCHEMICAL JOURNAL

The Structure and Regulation of Human Muscle α-Actinin

(2014) Euripedes de Almeida Ribeiro et al.   CELL

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

(2013) Daniel R. Roe et al.   Journal of Chemical Theory and Computation

The length-tension curve in muscle depends on lattice spacing

(2013) C. D. Williams et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Thick-to-Thin Filament Surface Distance Modulates Cross-Bridge Kinetics in Drosophila Flight Muscle

(2012) Bertrand C.W. Tanner et al.   BIOPHYSICAL JOURNAL

α-Actinin2 is required for the lateral alignment of Z discs and ventricular chamber enlargement during zebrafish cardiogenesis

(2012) Jingchun Yang et al.   FASEB JOURNAL

TheDrosophilaZ-disc Protein Z(210) Is an Adult Muscle Isoform of Zasp52, Which Is Required for Normal Myofibril Organization in Indirect Flight Muscles

(2012) Maria B. Chechenova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

(2012) Bill R. Miller et al.   Journal of Chemical Theory and Computation

Fetal Cardiac Troponin Isoforms Rescue the Increased Ca2+Sensitivity Produced by a Novel Double Deletion in Cardiac Troponin T Linked to Restrictive Cardiomyopathy

(2011) Jose Renato Pinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sarcomeric Z-Disc and Z-Discopathies

(2011) Ralph Knöll et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width

(2010) Brenda Russell et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

α-Actinin Is Required for the Proper Assembly of Z-Disk/Focal-Adhesion-Like Structures and for Efficient Locomotion in Caenorhabditis elegans

(2010) Gary L. Moulder et al.   JOURNAL OF MOLECULAR BIOLOGY

Global Longitudinal Strain as a Major Predictor of Cardiac Events in Patients with Depressed Left Ventricular Function: A Multicenter Study

(2010) Aude Mignot et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms

(2010) Jonathan M. Elkins et al.   PROTEIN SCIENCE

Mutations in Alpha-Actinin-2 Cause Hypertrophic Cardiomyopathy

(2009) Christine Chiu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

α-Actinin structure and regulation

(2008) B. Sjöblom et al.   CELLULAR AND MOLECULAR LIFE SCIENCES