Article
Infectious Diseases
Se Ra Shin, Seong Mi Noh, Woo Kyung Jung, Sook Shin, Young Kyung Park, Dong Chan Moon, Suk-Kyung Lim, Yong Ho Park, Kun Taek Park
Summary: The study conducted in South Korea between 2017 and 2019 identified various ESC-resistant bacterial isolates in companion animals, with predominant species being E. coli, Klebsiella, and others. These isolates displayed diversity in sequence types and resistance genes.
Article
Microbiology
Feleke Moges, Mucheye Gizachew, Mulat Dagnew, Azanaw Amare, Bekele Sharew, Setegn Eshetie, Wondwossen Abebe, Yihenew Million, Tigist Feleke, Moges Tiruneh
Summary: The study aimed to assess MDR, ESBL, and carbapenemase-producing GNB in patients attending three referral hospitals in Amhara region. The results showed high rates of MDR and ESBL production, with E. coli and Klebsiella spp. being the most common ESBL producers. Klebsiella spp., Enterobacter spp., E. coli, and Citrobacter spp. were typical carbapenemase-producing isolates.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Veterinary Sciences
Vincent Plassard, Philippe Gisbert, Sophie A. Granier, Yves Millemann
Summary: The study aimed to test a surveillance protocol for detecting specific bacteria in dairy farms, with limitations including missing samples and lack of specificity in detection results.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Julieta Madrid-Morales, Aditi Sharma, Kelly Reveles, Carolina Velez-Mejia, Teri Hopkins, Linda Yang, Elizabeth Walter, Jose Cadena
Summary: This study aimed to validate and compare five published prediction models for ESBL-producing Enterobacteriaceae infections. The modified Hopkins and Duke prediction models were found to be the most accurate in discriminating between Gram-negative bacteremia patients in a veteran population.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Abdurezak Zakir, Belayneh Regasa Dadi, Addis Aklilu, Yisiak Oumer
Summary: This study found a high prevalence of ES beta L-producing gram-negative bacilli among neonates, with a significant association between rectal carriage of ES beta L and factors such as endotracheal intubation, specific antibiotic treatments, and length of stay in the neonatal intensive care unit. Continuous monitoring of drug resistance patterns is crucial for effective treatment and management of these bacteria.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Camille Gonzalez, Herve Volland, Saoussen Oueslati, Lea Niol, Camille Legrand, Laura Francius, Arnaud Chalin, Anais Vogel, Stephanie Simon, Thierry Naas
Summary: A LFIA prototype has been developed and evaluated for the rapid and reliable detection of GES-type beta-lactamases. The method is efficient, rapid, and easy to implement, making it suitable for confirmation of GES-type beta-lactamases in clinical microbiology laboratories.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Qian Xu, Ying Fu, Jingshu Ji, Xiaoxing Du, Yunsong Yu
Summary: The study revealed the combined effect of aztreonam and amoxicillin/clavulanic acid against carbapenem-resistant Gram-negative pathogens, showing bactericidal effects against infections caused by MBL-producing CR-GNOs.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Microbiology
Yuvaneswary Veloo, Syahidiah S. A. Thahir, Sakshaleni Rajendiran, Lim K. Hock, Norazah Ahmad, Vickneshwaran Muthu, Rafiza Shaharudin
Summary: The indiscriminate use of antibiotics in poultry farming has led to the emergence of antibiotic-resistant bacteria in poultry products and the surrounding environment. This study found high rates of multidrug-resistant Gram-negative bacteria in the environment of poultry farms, with some strains exhibiting resistance to multiple antibiotics. The presence of these bacteria poses a significant threat to the effectiveness of available antibiotics in treating infectious diseases. Efforts to regulate antibiotic use and conduct research on One Health issues are necessary to combat and prevent the spread of antibiotic-resistant bacteria.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Takuma Ohnishi, Yoshinori Mishima, Tomomi Naito, Nozomi Matsuda, Shohei Ariji, Daisuke Umino, Kikuko Tamura, Hajime Nishimoto, Keiji Kinoshita, Naonori Maeda, Azusa Kawaguchi, Ryuta Yonezawa, Shigenao Mimura, Hiroyuki Fukushima, Kenji Nanao, Makoto Yoshida, Toshio Sekijima, Isamu Kamimaki
Summary: This study aimed to clarify the risk factors and treatment strategies for febrile urinary tract infection (fUTI) caused by ESBL-producing bacteria in Japanese children. The results showed that children in the ESBL group were more likely to have a history of recent antibiotic use or prophylactic antibiotic use and experience recurrent UTIs. Most children with fUTI experience clinical improvement regardless of the choice of antibiotic.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Takuma Ohnishi, Yoshinori Mishima, Tomomi Naito, Nozomi Matsuda, Shohei Ariji, Daisuke Umino, Kikuko Tamura, Hajime Nishimoto, Keiji Kinoshita, Naonori Maeda, Azusa Kawaguchi, Ryuta Yonezawa, Shigenao Mimura, Hiroyuki Fukushima, Kenji Nanao, Makoto Yoshida, Toshio Sekijima, Isamu Kamimaki
Summary: This study aimed to clarify the risk factors and treatment strategies for febrile urinary tract infection (fUTI) caused by ESBL-producing bacteria in Japanese children. The results showed that children with a history of recent antibiotic use or prophylactic antibiotic use and recurrent UTIs were more likely to have fUTI caused by ESBL-producing bacteria. Regardless of the choice of antibiotic, most children with fUTI experienced clinical improvement.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Souha S. Kanj, Matteo Bassetti, Pattarachai Kiratisin, Camilla Rodrigues, Maria Virginia Villegas, Yunsong Yu, David van Duin
Summary: Multidrug-resistant Gram-negative bacteria pose a critical threat to healthcare. New antibiotics and combination therapies, including ceftazidime-avibactam, meropenem-vaborbactam, and ceftolozane-tazobactam, have shown effectiveness in treating these infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Felicia A. Owusu, Noah Obeng-Nkrumah, Esther Gyinae, Sarkodie Kodom, Rhodalyn Tagoe, Blessing Kofi Adu Tabi, Nicholas T. K. D. Dayie, Japheth A. Opintan, Beverly Egyir
Summary: Resistance to routine antimicrobials is observed in β-lactamase-producing Gram-negative bacteria (GNB) from clinical sources. The occurrence of carbapenemases, extended-spectrum β-lactamases (ESBLs), and AmpCs genes was also detected. Escherichia coli and Klebsiella pneumoniae were the most common GNB, with 46% and 17% prevalence respectively. Multi-drug resistance (MDR) was observed in 44% of the isolates.
Article
Public, Environmental & Occupational Health
Chen Shang, Run Yang, Ya Yang, Haomin Zhang, Jianjun Zhang, Qiang Xia, Yuan Gao, Yuxiao Deng
Summary: This study investigated the colonization rate, subsequent infections, and clinical outcomes of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in liver transplantation (LT) recipients. The results showed that ESBL-E colonization was not associated with ESBL-E infection or increased risk of ESBL-GNB infection. Furthermore, ESBL-E colonization did not lead to worse prognoses when compared with non-colonized patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Hemlata, Mujtaba Aamir Bhat, Vijay Kumar, Mohammad Z. Ahmed, Ali S. Alqahtani, Mohammed S. Alqahtani, Arif Tasleem Jan, Safikur Rahman, Archana Tiwari
Summary: The study identified 20 ESBLs in bacteria from wastewater treatment plants, with 11 bla(CTX-M) positive isolates, and discovered a novel CTX-M-152 inhibitor, Ellagic acid.
MICROBIAL PATHOGENESIS
(2021)
Article
Medicine, General & Internal
Doreen Mloka, Raphael Z. Sangeda, Kennedy D. Mwambete, Appolinary R. Kamuhabwa
Summary: This study investigated the prevalence of beta-lactamase-producing Gram-positive pathogens and Enterobacteriaceae with extended-spectrum beta-lactamase (ESBL) in Dar es Salaam, Tanzania. The results showed a high proportion of these bacteria strains are resistant to cephalosporins and exhibit beta-lactamase or ESBL production.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Microbiology
Sanmarie Schlebusch, Rikki M. A. Graham, Amy V. Jennison, Melissa M. Lassig-Smith, Patrick N. A. Harris, Jeffrey Lipman, Paraic O. Cuiv, David L. Paterson
Summary: This study found that using routine rectal swab collection techniques for testing the gut microbiome in intensive care patients is useful and yields similar results to fecal samples. This finding is significant for clinical practice.
Article
Immunology
Brian M. Forde, Haakon Bergh, Thom Cuddihy, Krispin Hajkowicz, Trish Hurst, E. Geoffrey Playford, Belinda C. Henderson, Naomi Runnegar, Julia Clark, Amy Jennison, Susan Moss, Anna Hume, Hugo Leroux, Scott A. Beatson, David L. Paterson, Patrick N. A. Harris
Summary: This study implemented a program of routine sequencing of multi-drug resistant organisms and used custom analysis pipeline to automate reporting and support infection control interventions. The results showed the identification of transmission events within three hospitals, highlighting the feasibility of routine WGS for MDR pathogens.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Burcu Isler, Abdullah Tarik Aslan, Murat Akova, Patrick Harris, David L. Paterson
Summary: This article reviews the literature on the treatment of OXA-48-like and NDM-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) and provides updated information on available antibiotic treatment strategies. The best treatment option for OXA-48 producers is ceftazidime-avibactam, followed by colistin. There is an unmet need for the treatment of NDM producers, but ceftazidime-avibactam and aztreonam combination or cefiderocol can be used if available.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
Article
Pathology
Jill Parkes-smith, Haakon Bergh, Patrick N. A. Harris
Summary: Staphylococcus aureus bacteraemia has high morbidity and mortality, and timely use of effective antibiotics is crucial. Molecular diagnostics can shorten the time from blood culture positivity to identification of MRSA or MSSA.
Letter
Immunology
Pranita D. Tamma, Patrick N. A. Harris, Amy J. Mathers, Eric Wenzler, Romney M. Humphries
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Jessica Schults, Felicity Edwards, Karina Charles, Adam D. D. Irwin, Claire M. M. Rickard, Patrick N. A. Harris, David L. L. Paterson, Kevin Laupland
Summary: This study aimed to determine the incidence, risk factors, and outcomes of Moraxella species bloodstream infection (BSI) in a large Australian population. The incidence rate was 4.3 per million residents, with males and infants having the highest risk. The 30-day all-cause case-fatality rate was 4%, and it was significantly higher among adults compared to children.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Amanda Corley, Amanda J. Ullman, Nicole Marsh, Jodie Genzel, Emily N. Larsen, Emily Young, Catriona Booker, Patrick N. A. Harris, Claire M. Rickard
Summary: This study aimed to determine the feasibility of using evidence-based securement bundles to reduce peripheral intravenous catheter (PIVC) failure. The results showed that conducting a large randomized controlled trial (RCT) on securement bundles is feasible, with adjustments to the screening process. Innovative dressing and securement solutions are needed to reduce the unacceptable PIVC failure rates.
Article
Microbiology
Holly A. Sinclair, Felicity Edwards, Patrick N. A. Harris, Claire Heney, Kevin B. Laupland
Summary: A retrospective population-based cohort study conducted in Queensland, Australia revealed that the incidence of Aeromonas species bloodstream infection (BSI) was relatively low in the region and did not show significant changes over a 20-year period. The study also found that the occurrence of Aeromonas species BSI varied significantly in different seasons, climate zones, and geographical locations, with higher rates observed in tropical north regions and among elderly males.
Article
Infectious Diseases
Adam G. G. Stewart, Jason A. A. Roberts, Brian M. M. Forde, Haakon Bergh, Timothy J. J. Kidd, Hugh Wright, Patrick N. A. Harris
Summary: Elizabethkingia meningoseptica is a rare multidrug-resistant gram-negative bacterium that primarily causes infections in vulnerable hosts. It can cause severe sepsis and complicated infections, and there is limited data on suitable therapeutic options. This study presents a case of prolonged bloodstream and central nervous system infection due to E. meningoseptica, treated with dose-optimized combination antibiotic therapy, but showed evidence of microbiological and clinical failure.
MICROBIAL DRUG RESISTANCE
(2023)
Article
Microbiology
Budi Permana, Patrick N. A. Harris, Naomi Runnegar, Margaret Lindsay, Belinda C. Henderson, E. G. Playford, David L. Paterson, Scott A. Beatson, Brian M. Forde
Summary: An outbreak of vanB-type VREfm ST78 occurred in a large tertiary Australian hospital. Whole-genome sequencing revealed a complex transmission route involving unknown environmental reservoirs. This genomic analysis provided detailed information on the local epidemiology of the outbreak strain and facilitated better targeted control measures for VREfm.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Nicole G. Ertl, Adam D. Irwin, Joanne Macdonald, Michelle J. Bauer, Claire Y. T. Wang, Patrick N. A. Harris, Claire Heney, Hosam M. Zowawi, David M. Whiley
Summary: In this study, rapid diagnostic assays using recombinase polymerase amplification with lateral flow detection (RPA-LF) were developed and tested for detecting the beta-lactamase genes CTX-M and CMY-2. The assays showed high sensitivity (82.1% - 100%) and specificity (100%), with a short turnaround time (15-20 min). The results suggest that these RPA-LF assays have the potential to be used in clinical and low-resource settings for rapid antimicrobial resistance detection.
JAC-ANTIMICROBIAL RESISTANCE
(2023)
Article
Medicine, General & Internal
Natalie Davidson, Felicity Edwards, Patrick N. A. Harris, Kevin B. Laupland
Summary: This study aimed to determine the incidence and risk factors for developing Vibrio species bloodstream infections and compare differences between different species. The study found an incidence rate of 1.2 cases/1 million person-years for Vibrio infections in Australia, with the highest incidence occurring in the summer months and in the tropical north. Increasing age, male sex, and multiple comorbidities were identified as risk factors. Vibrio vulnificus was the most frequently isolated pathogen and associated with the most severe disease. The overall case fatality rate was 19%.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Medicine, General & Internal
Adam G. Stewart, Claire Heney, David L. Paterson, Patrick N. A. Harris, Felicity Edwards, Kevin B. Laupland
Summary: A 20-year study in Queensland, Australia, found that Scedosporium and Lomentospora species, which are environmental moulds, rarely cause bloodstream infection in immunocompromised hosts. Among 22 incident episodes of Scedosporium and Lomentospora species bloodstream infection, 18 were caused by Lomentospora prolificans, 3 by Scedosporium apiospermum complex, and 1 by a nonspeciated Scedosporium species. The overall mortality rate for these patients was high, with 81% dying during their index admission and all-cause mortality at 30, 90, and 365 days being 73%, 82%, and 91% respectively. In addition, all 20 patients with haematological malignancy died within 365 days of follow-up, with a median time to death of 9 days following the diagnosis of bloodstream infection.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)