期刊
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
卷 80, 期 3, 页码 545-563出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MMBR.00005-16
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资金
- National Research Foundation of Korea grant - the South Korean government (MSIP) [20110030049]
- research fund of Hanyang University [HY-2014-P]
Heterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA (rDNA) heterochromatin, epigenetic states contribute to gene silencing and genome stability, which are required for proper chromosome segregation and a normal life span. Here, we focus on recent advances in the epigenetic regulation of rDNA silencing in Saccharomyces cerevisiae and in mammals, including regulation by several histone modifications and several protein components associated with the inner nuclear membrane within the nucleolus. Finally, we discuss the perturbations of rDNA epigenetic pathways in regulating cellular aging and in causing various types of diseases.
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