Article
Biochemistry & Molecular Biology
Vicneswarry Dorairaj, Siti Aishah Sulaiman, Nadiah Abu, Nor Azian Abdul Murad
Summary: The global prevalence of nonalcoholic fatty liver disease (NAFLD) or metabolic associated fatty liver disease (MAFLD) is increasing, necessitating the search for alternative techniques or tools for accurate diagnosis. Early detection is important because nonalcoholic steatohepatitis (NASH) is a marker for severe disease progression. This review summarizes the current noninvasive tools for NAFLD diagnosis and their performance, as well as discussing potential and newer alternative tools for diagnosing NAFLD.
Review
Medical Laboratory Technology
Mei Xue, Wei Chen, Xu Li
Summary: EV-transferred lncRNAs play crucial roles in cancer progression and show significant potential as noninvasive biomarkers or therapeutic targets for cancer diagnosis and treatment, particularly in bladder cancer (BC).
CLINICA CHIMICA ACTA
(2021)
Article
Multidisciplinary Sciences
Qichen Shen, Zhuizui Huang, Jiachen Yao, Yuanxiang Jin
Summary: This review discusses the modulatory functions of extracellular vesicles (EVs) in the intestine, with a focus on their roles and applications in the clinical therapy of inflammatory bowel disease (IBD). By establishing EV-mediated interaction systems between host intestine and microbiota, the possible mechanisms of IBD pathogenesis and its cure are described.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Nutrition & Dietetics
Bin Zeng, Ting Chen, Jun-Yi Luo, Lin Zhang, Qian-Yun Xi, Qing-Yan Jiang, Jia-Jie Sun, Yong-Liang Zhang
Summary: Extracellular vesicles (EVs) containing noncoding RNAs (ncRNAs), such as microRNAs, long noncoding RNAs, and circular RNAs, are crucial for intercellular communication. Milk-derived EV ncRNAs have been shown to play significant roles in biological processes and may have epigenetic regulatory effects in recipients. Further research is needed to fully understand the precise functions of milk EV ncRNAs.
ADVANCES IN NUTRITION
(2021)
Review
Medicine, Research & Experimental
Linling Chen, Qianmin Ou, Xiaoxing Kou
Summary: This review comprehensively summarizes the various roles of extracellular vesicles (EVs) in the pathogenesis and treatment of inflammatory bowel disease (IBD), highlighting the challenges and future directions in this field. It provides valuable insights into the indispensable roles of EVs in IBD and offers ideas for future therapeutic strategies.
Review
Nanoscience & Nanotechnology
De-feng Li, Mei-feng Yang, Jing Xu, Hao-ming Xu, Min-zheng Zhu, Yu-jie Liang, Yuan Zhang, Cheng-mei Tian, Yu-qiang Nie, Rui-yue Shi, Li-sheng Wang, Jun Yao
Summary: The rapid development of extracellular vesicles (EVs) based nanotechnology has provided unprecedented opportunities for nanomedicine platforms. EVs, such as exosomes and exosome-like nanoparticles, play important roles in the pathogenesis of inflammatory bowel disease (IBD) through their interaction and communication with intestinal epithelial cells, immune cells, and gut microbiota. They have the potential to be used as theranostic nanomedicine for IBD treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Gastroenterology & Hepatology
M. Valter, S. Verstockt, J. A. Finalet Ferreiro, I Cleynen
Summary: Extracellular vesicles are important mediators of intercellular communication, playing key roles in physiological and pathological processes such as immune regulation and intestinal epithelial repair. Their presence in body fluids offers opportunities for diagnostic, prognostic, and therapeutic applications, particularly in the context of inflammatory bowel disease.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Biochemistry & Molecular Biology
Kangchun Wang, Xin Wang, Qi Pan, Bei Zhao
Summary: Liquid biopsy is a noninvasive detection method that shows promising prospects in the diagnosis, treatment monitoring, and prognosis assessment of pancreatic cancer.
Review
Engineering, Environmental
Han Liu, Jinru Sun, Mingkai Wang, Sicheng Wang, Jiacan Su, Can Xu
Summary: Inflammatory bowel disease (IBD) is a serious gastrointestinal disease characterized by pain, diarrhea, and bloody stools. Intestinal organoids and organoids extracellular vesicles (OEVs) have shown great potential in IBD treatment. Intestinal organoids have various applications in disease modeling, drug development, and host-microbe interactions, while OEVs have physiological effects and can participate in physiological and pathological processes. This review provides an overview of IBD and its current treatments, as well as the construction and applications of intestinal organoids and OEVs in IBD treatment. The advantages and challenges of these approaches are also discussed.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Oncology
Weiqiang Tang, Min Xia, Yajie Liao, Yuan Fang, Gebo Wen, Jing Zhong
Summary: Exosomes are lipid bilayer extracellular vesicles that play critical roles in cancer initiation and progression, including TNBC. Tumor-derived exosomes have been found to be involved in various key processes of cancer, such as invasion, metastasis, angiogenesis, epithelial-mesenchymal transition, and drug resistance. Their dysregulation has been linked to the clinicopathological characteristics and prognosis of TNBC patients, making them a potential target for diagnosis and treatment.
Article
Chemistry, Multidisciplinary
Jingang Liu, He Ren, Chen Zhang, Jiexin Li, Qian Qiu, Nan Zhang, Ning Jiang, Jonathan F. Lovell, Yumiao Zhang
Summary: A nested delivery system for orally taking the anti-inflammatory cytokine IL-10 for the treatment of inflammatory bowel disease (IBD) is developed. Compared with intravenous or intramuscular administration routes, this new method for orally taking protein has high patient compliance. This study also provides a versatile methodology for other oral protein-based therapeutics delivery.
Article
Neurosciences
Shiqian Han, Meng Ren, Tianyin Kuang, Mao Pang, Dongwei Guan, Yesong Liu, Yong Wang, Wengeng Zhang, Zhijia Ye
Summary: This study revealed dysregulated lncRNA expression patterns in NP-C disease, potentially playing a crucial role in its pathogenesis. RNA-seq analysis showed that mRNAs coexpressed with lncRNAs are mainly associated with immune system-related processes and neuroinflammation. Knockdown of specific lncRNAs could improve intracellular ROS levels and cell viability, as well as suppress inflammatory responses in vitro.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Oncology
Eunice Eugenia Robless, Justin Andrew Howard, Ilaria Casari, Marco Falasca
Summary: Extracellular vesicles, particularly exosomes, are key players in intercellular communication, with a specific focus on their role in pancreatic cancer. Long non-coding RNAs (lncRNAs) within these vesicles are of increasing interest as potential biomarkers and therapeutic targets for pancreatic cancer, yet their precise functions within cancer exosomes remain unclear.
Review
Endocrinology & Metabolism
Susanne N. Wijesinghe, Thomas Nicholson, Kostas Tsintzas, Simon W. Jones
Summary: Obesity is associated with chronic low-grade inflammation and long noncoding RNAs have been identified as key regulators of inflammatory pathways. Some lncRNAs are differentially expressed in obesity and related conditions like insulin resistance, type 2 diabetes, sarcopenia, osteoarthritis, and rheumatoid arthritis. Understanding the role of lncRNAs in mediating obesity-associated inflammation may lead to new therapeutic targets.
Review
Medicine, Research & Experimental
Fang Wei, Yan Li
Summary: Exosomes, as important messengers, play a crucial role in regulating the tumor immune microenvironment. Noncoding RNAs encapsulated in exosomes have significant regulatory functions in the tumor immune microenvironment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Saman Firoozi, Sara Pahlavan, Mohammad-Hossein Ghanian, Shahram Rabbani, Maryam Barekat, Abdoreza Nazari, Mohammad Pakzad, Faezeh Shekari, Seyedeh-Nafiseh Hassani, Fariba Moslem, Fatemeh Nobakht Lahrood, Mansoureh Soleimani, Hossein Baharvand
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Review
Engineering, Biomedical
Fatemeh Mehryab, Shahram Rabbani, Soraya Shahhosseini, Faezeh Shekari, Yousef Fatahi, Hossein Baharvand, Azadeh Haeri
ACTA BIOMATERIALIA
(2020)
Article
Biochemistry & Molecular Biology
Mehdi Alikhani, Fatemehsadat Amjadi, Mehdi Mirzaei, Yunqi Wu, Faezeh Shekari, Mahnaz Ashrafi, Mehdi Mehdizadeh, Matthew McKay, Sara Taleahmad, Samaneh Aghajanpour, Vivek Gupta, Hossein Baharvand, Reza Aflatoonian, Ghasem Hosseini Salekdeh
MOLECULAR BIOLOGY REPORTS
(2020)
Correction
Biochemistry & Molecular Biology
Padideh Karimi, Ali Gheisari, Sylvia J. Gasparini, Hossein Baharvand, Faezeh Shekari, Leila Satarian, Marius Ader
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Aida Ansari, Babak Andalibi, Mehdi Zarei, Farid Shekari
Summary: This study demonstrated that under Pb stress, mycorrhiza can improve growth and tolerance of Lallemantia iberica, while the proper concentration of putrescine combined with mycorrhiza and Pb stress can enhance plant performance.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Pathology
Raheleh Heydari, Meghdad Abdollahpour-Alitappeh, Faezeh Shekari, Anna Meyfour
Summary: In-depth analysis of EV content can lead to the identification of new potential biomarkers for early diagnosis and prognosis prediction of GI diseases. The use of a more targeted approach by establishing more reproducible and standardized methods to decrease variations and obtain desired EV population as well as revisiting large pools of identified biomarkers and their evaluation in larger patient cohorts can result in the introduction of more reliable biomarkers in clinic.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2021)
Article
Obstetrics & Gynecology
Farnoosh Saraee, Faezeh Shekari, Ashraf Moini, Marya Sadeghi, Pooneh Ghaznavi, Abdoreza Nazari, Azadeh Ghaheri, Mehdi Totonchi, Poopak Eftekhari-Yazdi
Summary: The study found that pre-implantation uterine fluid lavage did not affect implantation and clinical pregnancy rates. Three different methods (ultracentrifugation, sucrose cushion and qEV column) were successful in isolating extracellular vesicles from uterine fluid lavage.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Pharmacology & Pharmacy
Sepand Tehrani Fateh, Sahand Tehrani Fateh, Faezeh Shekari, Majid Mahdavi, Amir Reza Aref, Amir Salehi-Najafabadi
Summary: Cellular differentiation plays a crucial role in health and disease, and interfering with this process can be used as a therapeutic approach. Sesquiterpene lactones, found in plants, have been studied for their differentiating/dedifferentiating effects on human and animal cells. However, there is a lack of consensus on their effects and mechanism of action. Further research is needed to fully understand the potential of sesquiterpene lactones in treating obesity, osteoporosis, and cancer, including reporting negative results and investigating other cells, sesquiterpene lactones, and signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Mehrdad Shokouhy, Hamzeh Sarvnaz, Yasaman Taslimi, Mahya Sadat Lajevardi, Sima Habibzadeh, Amir Mizbani, Faezeh Shekari, Mandana Behbahani, Ana Claudia Torrecilhas, Sima Rafati
Summary: This study reports for the first time that L. tarentolae can release EVs and provides evidence that tEVs are able to control the infection in human macrophages, making them a great potential platform for drug delivery, at least for parasitic infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Behnaz Ahrabi, Hojjat Allah Abbaszadeh, Abbas Piryaei, Faezeh Shekari, Navid Ahmady Roozbahany, Mahya Rouhollahi, Forough Azam Sayahpour, Mahnaz Ahrabi, Hadi Azimi, Reza Moghadasali
Summary: This study aimed to evaluate whether extracellular vesicles (EVs) derived from autophagic adipose-derived mesenchymal stem cells (ADMSCs) can reduce inflammation and extracellular matrix accumulation in damaged kidney tissue. The results showed that treatment with AEVs significantly reduced the expression of fibrotic and pro-inflammatory genes compared to NEVs, suggesting that AEVs could be a potential therapeutic modality for renal fibrosis.
Review
Immunology
Samaneh Saberi, Maryam Esmaeili, Reza Saghiri, Faezeh Shekari, Marjan Mohammadi
Summary: This study investigates the feasibility of toxin transfer by extracellular vesicles produced by H. pylori. The results show that both bacterial vesicles and infected cell vesicles can carry bacterial toxins and transfer them to recipient cells through an acellular pathway. This transfer leads to IL-8 production and morphological changes in the recipient cells.
MICROBIAL PATHOGENESIS
(2023)
Article
Neurosciences
Faezeh Shekari, Morteza Abyadeh, Anna Meyfour, Mehdi Mirzaei, Nitin Chitranshi, Vivek Gupta, Stuart L. Graham, Ghasem Hosseini Salekdeh
Summary: A large number of people around the world suffer from visual impairment, and the available therapies focus on preventing the progression of eye disorders. This review explores the potential of using extracellular vesicles (EVs) as a regenerative therapy for eye-related complications. The review examines the current knowledge about EVs and their therapeutic applications, as well as the challenges in translating EV-based therapy into clinical settings.
PROGRESS IN NEUROBIOLOGY
(2023)
Review
Cell & Tissue Engineering
Faezeh Shekari, Abdoreza Nazari, Sara Assar Kashani, Ensiyeh Hajizadeh-Saffar, Rebecca Lim, Hossein Baharvand
Summary: This article reviews the use of MSC-derived EVs in animal disease models over the past decade. The study categorizes and critically discusses the technical aspects of these pre-clinical studies, exploring potential relationships between methodological details and the effectiveness of MSC-EVs.
Article
Cell Biology
Carolina Soekmadji, Bo Li, Yiyao Huang, Haifang Wang, Taixue An, Chunchen Liu, Weilun Pan, Jing Chen, Lesley Cheung, Juan Manuel Falcon-Perez, Yong Song Gho, Harry B. Holthofer, Minh T. N. Le, Antonio Marcilla, Lorraine O'Driscoll, Faezeh Shekari, Tang Long Shen, Ana Claudia Torrecilhas, Xiaomei Yan, Fuquan Yang, Hang Yin, Yu Xiao, Zezhou Zhao, Xue Zou, Qian Wang, Lei Zheng
JOURNAL OF EXTRACELLULAR VESICLES
(2020)