Article
Clinical Neurology
Verena Rass, Ronny Beer, Alois Josef Schiefecker, Anna Lindner, Mario Kofler, Bogdan Andrei Ianosi, Philipp Mahlknecht, Beatrice Heim, Marina Peball, Federico Carbone, Victoria Limmert, Philipp Kindl, Lauma Putnina, Elena Fava, Sabina Sahanic, Thomas Sonnweber, Wolfgang N. Loescher, Julia Wanschitz, Laura Zamarian, Atbin Djamshidian, Ivan Tancevski, Gunter Weiss, Rosa Bellmann-Weiler, Stefan Kiechl, Klaus Seppi, Judith Loeffler-Ragg, Bettina Pfausler, Raimund Helbok
Summary: The study showed that around 15% of patients experienced new or persistent neurological disorders 1 year after COVID-19, with 59% reporting symptoms such as fatigue, concentration difficulties, forgetfulness, and sleep disturbances. Neurological examination revealed findings in 64% of patients, with 51% showing objective hyposmia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Editorial Material
Neurosciences
Abdul Mannan Baig
Summary: Long-COVID patients are showing persistent and ominous neurological deficits that lead to disabilities, with the mechanisms behind these symptoms still unclear. Factors such as viral load location, differential immune response, neurodegenerative changes, and inflammation are debated as potential causative factors that need further investigation for understanding the pathogenesis of neuro-COVID in long-COVID syndrome.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Immunology
Marco Contoli, Alberto Papi, Luca Tomassetti, Paola Rizzo, Francesco Vieceli Dalla Sega, Francesca Fortini, Francesca Torsani, Luca Morandi, Luca Ronzoni, Ottavio Zucchetti, Rita Pavasini, Alberto Fogagnolo, Carlo Alberto Volta, Nathan W. Bartlett, Sebastian L. Johnston, Savino Spadaro, Gianluca Campo
Summary: This study demonstrates that COVID-19 patients have lower levels of blood IFN-alpha compared to controls, and as the disease progresses, the IFN-alpha levels decrease while IL-10 expression increases. Survivors show a significant increase in IFN-alpha levels, while patients who died had higher levels of IL-10.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
V. A. Blanco-Palmero, F. J. Azcarate-Diaz, M. Ruiz-Ortiz, M. I. Laespada-Garcia, P. Rabano-Suarez, A. Mendez-Guerrero, M. Aramendi-Ramos, J. L. Eguiburu, A. Perez-Rivilla, A. Marchan-Lopez, M. Rubio-Fernandez, E. Carro, J. Gonzalez de la Aleja
Summary: This study did not find evidence of increased expression of alpha-synuclein in individuals with neurological symptoms in COVID-19. Further research involving a larger group of COVID-19 patients with a wide spectrum of neurological manifestations and disease severity is needed.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Saikat Dewanjee, Jayalakshmi Vallamkondu, Rajkumar Singh Kalra, Nagaprasad Puvvada, Ramesh Kandimalla, P. Hemachandra Reddy
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has led to a year-long phase of public health adversaries and compromised healthcare globally. Understanding of neurological complications in COVID-19 patients is still limited, and factors such as age, sex, comorbidity, and disease severity play a role in exacerbating neurological manifestations in these patients.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Lu Lu, Lei Chen, Peiyu Wang, Zhang Qi, Yujie Chen, Xintong Wu, Xu Liu, Minjin Wang, Jinmei Li, Bo Yan, Jian Guo, Sisi Teng, Weimin Li, Josemir W. Sander, Dong Zhou, Weixi Xiong
Summary: This study investigated the neurological complications associated with COVID-19 during the 2022 Omicron wave. The findings showed an increase in new-onset neurological symptoms, particularly encephalitis and encephalopathy, during this period. Deterioration of existing neurological conditions was also observed. This highlights the need for large-scale treatment trials for patients with COVID-19 and neurological disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Pharmacology & Pharmacy
Waldemar Brola, Maciej Wilski
Summary: COVID-19 infection can lead to various neurological complications, including encephalopathy, meningitis, and stroke. Early symptoms often include olfactory and gustatory disorders, while severe neurological manifestations are relatively rare but increasing in number.
PHARMACOLOGICAL REPORTS
(2022)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Vignesh Chidambaram, Amudha Kumar, Marie Gilbert Majella, Bhavna Seth, Ranjith Kumar Sivakumar, Dinesh Voruganti, Mahesh Bavineni, Ahmad Baghal, Kim Gates, Annu Kumari, Subhi J. Al'Aref, Panagis Galiatsatos, Petros C. Karakousis, Jawahar L. Mehta
Summary: This study found that individuals with higher antecedent serum high-density lipoprotein cholesterol (HDL-C) levels had a lower risk of SARS-CoV-2 infection. However, low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) levels were not independently associated with infection risk. In COVID-19 patients, serum HDL-C and LDL-C levels transiently decreased at the time of infection.
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Medicine, General & Internal
Devang K. Sanghavi, Shivang Bhakta, Hani M. Wadei, Wendelyn Bosch, Jennifer B. Cowart, Rickey E. Carter, Sadia Z. Shah, Benjamin D. Pollock, Matthew R. Neville, Sven P. Oman, Leigh Speicher, Jason Siegel, Ameya D. Scindia, Claudia R. Libertin, Katie L. Kunze, Patrick W. Johnson, Mark W. Matson, Pablo Moreno Franco
Summary: This study found that hospitalized breakthrough cases were more likely to have underlying risk factors than unvaccinated patients. In breakthrough cases admitted to the hospital, low-spike antibody titers may serve as an indicator for poor prognosis.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Anna L. McNaughton, Robert S. Paton, Matthew Edmans, Jonathan Youngs, Judith Wellens, Prabhjeet Phalora, Alex Fyfe, Sandra Belij-Rammerstorfer, Jai S. Bolton, Jonathan Ball, George W. Carnell, Wanwisa Dejnirattisai, Christina Dold, David W. Eyre, Philip Hopkins, Alison Howarth, Kreepa Kooblall, Hannah Klim, Susannah Leaver, Lian Ni Lee, Cesar Lopez-Camacho, Sheila F. Lumley, Derek C. Macallan, Alexander J. Mentzer, Nicholas M. Provine, Jeremy Ratcliff, Jose Slon-Compos, Donal Skelly, Lucas Stolle, Piyada Supasa, Nigel Temperton, Chris Walker, Beibei Wang, Duncan Wyncoll, Peter Simmonds, Teresa Lambe, John Kenneth Baillie, Malcolm G. Semple, Peter J. M. Openshaw, Uri Obolski, Marc Turner, Miles Carroll, Juthathip Mongkolsapaya, Gavin Screaton, Stephen H. Kennedy, Lisa Jarvis, Eleanor Barnes, Susanna Dunachie, Jose Lourenco, Philippa C. Matthews, Tihana Bicanic, Paul Klenerman, Sunetra Gupta, Craig P. Thompson
Summary: The immune response to the SARS-CoV-2 virus in fatal COVID-19 cases is enriched for antibodies that target epitopes shared with other endemic coronaviruses, rather than the more protective regions of the virus. This response is correlated with the magnitude of antibody responses to the spike protein of both SARS-CoV-2 and other beta-coronaviruses in individuals admitted to the ICU with fatal outcomes. However, there is no significant difference in antibody responses to the less cross-reactive SARS-CoV-2 nucleocapsid between fatal and nonfatal cases.
Article
Multidisciplinary Sciences
Marcia C. Castro, Sun Kim, Lorena Barberia, Ana Freitas Ribeiro, Susie Gurzenda, Karina Braga Ribeiro, Erin Abbott, Jeffrey Blossom, Beatriz Rache, Burton H. Singer
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Review
Clinical Neurology
Erin F. Balcom, Avindra Nath, Christopher Power
Summary: COVID-19 is a global pandemic caused by SARS-CoV-2 infection, leading to acute and chronic disorders affecting the nervous system. Acute neurological symptoms include stroke, seizures, and cognitive dysfunction, while chronic neurological sequelae such as exercise intolerance and pain are reported. Various studies suggest potential mechanisms of viral neuroinvasion, but further research is needed to understand the underlying pathogenic processes.
