HSP90 Exacerbates Bone Destruction in Rheumatoid Arthritis by Activating TRAF6/NFATc1 Signaling

RANKL as the master regulator of osteoclast differentiation

(2021) Hiroshi Takayanagi   JOURNAL OF BONE AND MINERAL METABOLISM

Artesunate attenuates bone erosion in rheumatoid arthritis by suppressing reactive oxygen species via activating p62/Nrf2 signaling

(2021) Xiaohui Su et al.   BIOMEDICINE & PHARMACOTHERAPY

Fengshi Qutong capsule ameliorates bone destruction of experimental rheumatoid arthritis by inhibiting osteoclastogenesis

(2021) Yiqun Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Systemic effects of IL-6 blockade in rheumatoid arthritis beyond the joints

(2021) Matthias Jarlborg et al.   CYTOKINE

Imperative and effective reversion of synovial hyperplasia and cartilage destruction in rheumatoid arthritis through multiple synergistic effects of O2 and Ca2+

(2020) Xue Rui et al.   Materials Science & Engineering C-Materials for Biological Applications

Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca2+-NFATc1 signaling pathway

(2019) Xiang-zhou Zeng et al.   ACTA PHARMACOLOGICA SINICA

Triptolide, a HSP90 middle domain inhibitor, induces apoptosis in triple manner

(2018) Frederick Zhehao Zhang et al.   Oncotarget

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease

(2018) Abdullah Hoter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autoantibodies to heat shock proteins 60, 70, and 90 in patients with rheumatoid arthritis

(2018) Jagoda Mantej et al.   CELL STRESS & CHAPERONES

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat shock proteins 70 and 90 from Clonorchis sinensis induce Th1 response and stimulate antibody production

(2017) Eun Joo Chung et al.   Parasites & Vectors

Heat shock protein 90: its inhibition and function

(2017) Abbey D. Zuehlke et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease

(2016) Matthew B. Greenblatt et al.   CLINICAL CHEMISTRY

Inhibition of RANKL-induced osteoclast differentiation through the downregulation of c-Fos and NFATc1 by Eremochloa ophiuroides (centipedegrass) extract

(2016) BO-YUN CHOI et al.   Molecular Medicine Reports

Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases

(2015) Stefan Tukaj et al.   EXPERIMENTAL DERMATOLOGY

Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia

(2015) Siddhartha Ganguly et al.   Oncotarget

M-CSF Priming of Osteoclast Precursors Can Cause Osteoclastogenesis-Insensitivity, Which Can be Prevented and Overcome on Bone

(2014) Teun J. de Vries et al.   JOURNAL OF CELLULAR PHYSIOLOGY

New regulation mechanisms of osteoclast differentiation

(2012) Tomoki Nakashima et al.   Annals of the New York Academy of Sciences

Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus

(2012) Samuel K Shimp et al.   Cellular & Molecular Immunology

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis

(2011) Tobias Braun et al.   ARTHRITIS RESEARCH & THERAPY

RANKL-induced TRPV2 expression regulates osteoclastogenesis via calcium oscillations

(2010) Hiroshi Kajiya et al.   CELL CALCIUM

Heat shock protein 90 maintains the tumour-like character of rheumatoid synovial cells by stabilizing integrin-linked kinase, extracellular signal-regulated kinase and protein kinase B

(2010) A. Hashiramoto et al.   RHEUMATOLOGY