期刊
MICROBIOLOGY AND IMMUNOLOGY
卷 60, 期 7, 页码 468-476出版社
WILEY
DOI: 10.1111/1348-0421.12390
关键词
atopic dermatitis; immunoglobulin E; Lactobacillus rhamnosus; tyndallization
The therapeutic effect of oral administration of Lactobacillus rhamnosus IDCC 3201 tyndallizate (RHT3201) on atopic dermatitis (AD)-like skin lesions in NC/Nga mice were investigated. After induction of dermatitis in NC/Nga mice with house-dust mite extract, each group was fed RHT3201 with 1x10(8), 1x10(9), or 1x10(10) cells orally once a day for 8 weeks. Dermatitis scores and frequency of scratching were improved by oral feeding with RHT3201. In contrast to the control group, RHT3201-fed mice showed significantly down-regulated mast cell numbers and serum immunoglobulin E (IgE) concentrations had significantly less IL4 in their axillary lymph node cells. The therapeutic effect of RHT3201 was found to be dose-dependent. These findings indicate that RHT3201 has potential for treating AD.
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