Article
Biochemistry & Molecular Biology
Yan Mao, Feng Jiang, Xue-Jiao Xu, Lan-Bo Zhou, Rui Jin, Li -Li Zhuang, Chen-Xia Juan, Guo-Ping Zhou
Summary: This study found that IGF2BP1 induces pyroptosis in renal tubular cells, which is associated with the development of septic acute kidney injury (AKI). The upregulation of MIF through IGF2BP1-mediated regulation of E2F1 was crucial for pyroptosis induction. Inhibiting IGF2BP1 could be a potential therapy for septic AKI.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Hao Shen, Keliang Xie, Miaomiao Li, Qianyu Yang, Xiaoye Wang
Summary: Recent studies have shown that m(6)A modification plays a significant role in sepsis-induced myocardial injury. METTL3, a key methyltransferase, regulates the levels of m(6)A modification and affects inflammatory damage in cardiomyocytes. The study also elucidates the mechanism of the METTL3/IGF2BP1/m(6)A/HDAC4 axis in sepsis-induced myocardial injury.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Wenjing Shi, Yongzhe Tang, Jing Lu, Yihui Zhuang, Jie Wang
Summary: This study clarifies the function and N6,2'-O-dimethyladenosine (m6A) regulation of lncRNA MIR210HG in breast cancer. MIR210HG promotes breast cancer progression through its encoded miR-210, which is regulated by IGF2BP1 mediated m6A modification. Additionally, IGF2BP1 and ELAVL1 enhance the stability of MIR210HG, contributing to the progression of breast cancer. MYCN directly activates IGF2BP1, explaining its oncogenic role.
CELL AND BIOSCIENCE
(2022)
Article
Neurosciences
Wei-Hong Hei, Ming-yuan Du, Hong He
Summary: This study investigated the role of RNA m6A in the differentiation and proliferation of dental pulp stem cells, as well as its potential to improve peripheral nerve regeneration in a rat model of crushed mental nerve injury. The results showed that RNA m6A participated in the differentiation of dental pulp stem cells, and the over-expression of METTL3 exhibited a greater ability to improve peripheral nerve regeneration compared to knock-down METTL3 and hDPSCs alone.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Angela Yu-Huey Hsu, Sung-Tsang Hsieh
Summary: Dectin-1 plays a role in peripheral nerve injury, and inhibiting it can delay nerve degeneration and angiogenesis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Genetics & Heredity
Lei Zhang, Dingyu Hao, Pengyi Ma, Boyuan Ma, Jia Qin, Guangyuan Tian, Zihao Liu, Xianhu Zhou
Summary: This study revealed significant alterations in m6A methylation pattern in peripheral nervous injury (PNI), with changes in genes related to immune system process, cell activation, and nervous system development. The m6A-modified genes were also found to be involved in regulating cell cycle, B cell receptor signaling pathway, axon guidance pathway, and calcium signaling pathway. Additionally, upregulation of autophagy-related gene (Atg7) m6A methylation and protein expression levels were observed, suggesting a potential role of m6A modification in promoting functional recovery after PNI.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Hansheng Wu, Haijie Xu, Shujie Huang, Yong Tang, Jiming Tang, Haiyu Zhou, Liang Xie, Guibin Qiao
Summary: Our study demonstrates that IGF2BP1 plays a contributory role in the development and progression of lung adenocarcinoma (LUAD). IGF2BP1 has the potential to become a prognostic predictor and therapeutic target for LUAD.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Benjamin R. Slavin, Karim A. Sarhane, Nicholas von Guionneau, Phillip J. Hanwright, Chenhu Qiu, Hai-Quan Mao, Ahmet Hoke, Sami H. Tuffaha
Summary: IGF-1 shows promise as a therapeutic target for peripheral nerve injuries, with various administration approaches being investigated in the literature. However, further research is needed to determine the optimal dosage ranges for clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Philip J. Hanwright, Chenhu Qiu, Jennifer Rath, Yang Zhou, Nicholas von Guionneau, Karim A. Sarhane, Thomas G. W. Harris, Gregory P. Howard, Harsha Malapati, Michael J. Lan, Sashank Reddy, Ahmet Hoke, Hai-Quan Mao, Sami H. Tuffaha
Summary: This study demonstrates the potential of a novel nanoparticle delivery system for targeted and sustained release of IGF-1, leading to improved motor recovery through amelioration of denervation-induced muscle atrophy and SC senescence and enhanced axonal regeneration.
Article
Cell Biology
Ying Zou, Shu Wu, Fei Wen, Yuanlong Ge, Shengkang Luo
Summary: PGC-1a negatively regulates Schwann cell dedifferentiation and nerve degeneration after peripheral nerve injury, and its activation reduces peripheral nerve degeneration by inhibiting the expression of PON1.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Anru Liang, Jianyu Liu, Yanlin Wei, Yuan Liao, Fangxiao Wu, Jiang Ruan, Junjun Li
Summary: Emerging evidence suggests that m6A plays a critical role in vascular biology. However, the underlying mechanism of m6A regulation on vascular endothelial cells in high glucose conditions is unclear.
Article
Biochemistry & Molecular Biology
Lei Huang, Xinyu He, Wen Peng, Xueqing He, Bei Xu, Hu Xu, Yaoxing Wang, Wenjun Xu, Wentong Chen, Sheng Wang, Lanlan Zhou, Ning Liu, Youzhi Xu, Wenjie Lu
Summary: The molecular mechanisms of uric acid-induced liver injury have not been fully understood. This study revealed that uric acid directly activates inflammation and apoptosis pathways in liver cells, while inhibiting urea cycle enzymes. The upregulation of hypoxia inducible factor-1α by uric acid plays a role in these processes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Antonio-Andres, Gustavo U. Martinez-Ruiz, Mario Morales-Martinez, Elva Jimenez-Hernandez, Estefany Martinez-Torres, Tania V. Lopez-Perez, Laura A. Estrada-Abreo, Genaro Patino-Lopez, Sergio Juarez-Mendez, Victor M. Davila-Borja, Sara Huerta-Yepez
Summary: This study reveals that HIF-1 alpha can transcriptionally regulate YY1, and the expression of HIF-1 alpha positively correlates with YY1 in leukemia patients, suggesting that they may serve as therapeutic targets or biomarkers for ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Shan Shao, Yawen Zheng, Zibing Fu, Jiaxin Wang, Yu Zhang, Cheng Wang, Xuetao Qi, Tingting Gong, Longyu Ma, Xi Lin, Haitao Yu, Shulu Yuan, You Wan, Haolin Zhang, Ming Yi
Summary: Chronic pain is a major global medical problem. Recent evidence suggests that the hippocampus plays a role in modulating chronic pain, but the exact mechanisms remain unknown. In this study, a neural ensemble in the ventral hippocampal CA1 region was found to respond to noxious stimuli and become hypersensitive after peripheral inflammation. Manipulating the activity of these neurons in mice induced chronic pain-like behaviors or reduced pain-related behaviors, depending on the context. Additionally, specific pathways from the ventral hippocampus to the basolateral amygdala and infralimbic cortex were found to be involved in pain modulation at different stages of chronic inflammatory pain.
Article
Immunology
Lu Ding, Huiran Wu, Yi Wang, Yun Li, Zhanping Liang, Xiaohuan Xia, Jialin C. Zheng
Summary: The study reveals the distinct N6-methyladenosine (m6A) methylation patterns in LPS-activated microglia and identifies Igf2bp1 as the most significantly regulated m6A modifiers in these cells. Functional perturbation experiments suggest that Igf2bp1 may play a key role in LPS-induced m6A modification and microglial activation by enhancing m6A methylation and stability of Gbp11 and Cp mRNAs. This study provides insights into the mechanism of m6A methylation-mediated microglial regulation and suggests Igf2bp1 as a potential target for modulating the inflammatory responses of microglia.
FRONTIERS IN IMMUNOLOGY
(2022)