Evaluation of the anti-inflammatory effects of PI3Kδ/γ inhibitors for treating acute lung injury

Osthole Alleviates D-Galactose-Induced Liver Injury In Vivo via the TLR4/MAPK/NF-κB Pathways

(2023) Zhe Ma et al.   MOLECULES

Exploring PI3Kγ binding preference with Eganelisib, Duvelisib, and Idelalisib via energetic, pharmacophore and dissociation pathway analyses

(2022) Lei Jia et al.   COMPUTERS IN BIOLOGY AND MEDICINE

A novel inhalable quercetin-alginate nanogel as a promising therapy for acute lung injury

(2022) Yi-Bing Chen et al.   JOURNAL OF NANOBIOTECHNOLOGY

Investigation into the anti-airway inflammatory role of the PI3Kγ inhibitor JN-PK1: An in vitro and in vivo study

(2022) Wendian Xiong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Forsythiaside B ameliorates coagulopathies in a rat model of sepsis through inhibition of the formation of PAD4-dependent neutrophil extracellular traps

(2022) Wenju He et al.   Frontiers in Pharmacology

Developing a Naïve Bayesian Classification Model with PI3Kγ structural features for virtual screening against PI3Kγ: Combining molecular docking and pharmacophore based on multiple PI3Kγ conformations

(2022) Yingmin Jiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Integrated molecular modeling techniques to reveal selective mechanisms of inhibitors to PI3Kδ with marketed Idelalisib

(2021) Jingyu Zhu et al.   Chemical Biology & Drug Design

Distinct roles of PI3Kδ and PI3Kγ in a toluene diisocyanate-induced murine asthma model

(2021) Caiyun Xu et al.   TOXICOLOGY

Umbralisib: First Approval

(2021) Sohita Dhillon et al.   DRUGS

Discovery of Novel Selective PI3Kγ Inhibitors through Combining Machine Learning-Based Virtual Screening with Multiple Protein Structures and Bio-evaluation

(2021) Jingyu Zhu et al.   Journal of Advanced Research

TNF-α: The shape of small molecules to come?

(2021) Alexander Dömling et al.   DRUG DISCOVERY TODAY

Impaired airway epithelial barrier integrity was mediated by PI3Kδ in a mouse model of lipopolysaccharide-induced acute lung injury

(2021) Lihong Yao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A multi-conformational virtual screening approach based on machine learning targeting PI3Kγ

(2021) Jingyu Zhu et al.   MOLECULAR DIVERSITY

PI3K inhibitors are finally coming of age

(2021) Bart Vanhaesebroeck et al.   NATURE REVIEWS DRUG DISCOVERY

Development of PI3K inhibitors: advances in clinical trials and new strategies (Review)

(2021) Dandan Meng et al.   PHARMACOLOGICAL RESEARCH

All‑trans retinoic acid promotes macrophage phagocytosis and decreases inflammation via inhibiting CD14/TLR4 in acute lung injury

(2021) Shuangxue Li et al.   Molecular Medicine Reports

Rhoifolin Alleviates Inflammation of Acute Inflammation Animal Models and LPS-Induced RAW264.7 Cells via IKKβ/NF-κB Signaling Pathway

(2020) Jiaqi Fang et al.   INFLAMMATION

Computational investigation of the selectivity mechanisms of PI3Kδ inhibition with marketed idelalisib: combined molecular dynamics simulation and free energy calculation

(2020) Jingyu Zhu et al.   STRUCTURAL CHEMISTRY

Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors

(2020) Jingyu Zhu et al.   MEDICINAL RESEARCH REVIEWS

Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt

(2019) Yunjuan Nie et al.   MOLECULES

Alpelisib: First Global Approval

(2019) Anthony Markham   DRUGS

Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways

(2019) Maria Talita Pacheco de Oliveira et al.   International Journal of Nanomedicine

Theoretical studies on the selectivity mechanisms of PI3Kδ inhibition with marketed idelalisib and its derivatives by 3D-QSAR, molecular docking, and molecular dynamics simulation

(2019) Jingyu Zhu et al.   JOURNAL OF MOLECULAR MODELING

Recent discovery of phosphoinositide 3-kinase γ inhibitors for the treatment of immune diseases and cancers

(2019) Xiaqiu Qiu et al.   Future Medicinal Chemistry

Small Molecules Drive Big Improvements in Immuno-Oncology Therapies

(2018) Bayard R. Huck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

4-(Hydroxymethyl)catechol Extracted From Fungi in Marine Sponges Attenuates Rheumatoid Arthritis by Inhibiting PI3K/Akt/NF-κB Signaling

(2018) Jong Y. Lee et al.   Frontiers in Pharmacology

Duvelisib: First Global Approval

(2018) Hannah A. Blair   DRUGS

Class 1 PI3K Clinical Candidates and Recent Inhibitor Design Strategies: A Medicinal Chemistry Perspective

(2018) Aimie E. Garces et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases

(2018) Matthew W. D. Perry et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of selective phosphatidylinositol 3-kinase inhibitors to treat hematological malignancies

(2015) Jingyu Zhu et al.   DRUG DISCOVERY TODAY

Targeting the Phosphatidylinositol 3-Kinase/AKT Pathway for the Treatment of Multiple Myeloma

(2014) J. Zhu et al.   CURRENT MEDICINAL CHEMISTRY

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

(2014) Guillermo Arango Duque et al.   Frontiers in Immunology

PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models

(2013) David G. Winkler et al.   CHEMISTRY & BIOLOGY

BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models

(2013) Ningshu Liu et al.   MOLECULAR CANCER THERAPEUTICS

Biomarkers of ALI/ARDS: Pathogenesis, Discovery, and Relevance to Clinical Trials

(2013) Lorraine Ware et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

PI3K-γ Inhibition Ameliorates Acute Lung Injury Through Regulation of IκBα/NF-κB Pathway and Innate Immune Responses

(2011) Dong Im Kim et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Discovery of Dual Inhibitors of the Immune Cell PI3Ks p110δ and p110γ: a Prototype for New Anti-inflammatory Drugs

(2010) Olusegun Williams et al.   CHEMISTRY & BIOLOGY

The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine

(2010) Hong Chen et al.   Expert Review of Respiratory Medicine