期刊
MICROBIAL DRUG RESISTANCE
卷 22, 期 6, 页码 461-469出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2016.0053
关键词
-
资金
- NCBiR [PBS1/A8/8/2012]
- Foundation for Polish Science-SKILLS project: IMPULS competition - European Social Fund [87/UD/SKILLS/2014]
Staphylococcus aureus remains one of the most common and at the same time the most dangerous bacteria. The spreading antibiotic resistance calls for intensification of research on staphylococcal physiology and development of new strategies for combating this threatening pathogen. We have engineered new chimeric enzymes comprising the enzymatically active domain (EAD) of autolysin LytM from S. aureus and the cell wall binding domain (CBD) from bacteriocin lysostaphin. They display potent activity in extended environmental conditions. Our results exemplify the possibility of exploring autolytic enzymes in engineering lysins with desired features. Moreover, they suggest a possible mechanism of autolysin physiological activity regulation by local ionic environments in the cell wall.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据