期刊
MICROBES AND INFECTION
卷 18, 期 7-8, 页码 -出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2016.03.007
关键词
C-type lectin receptor; Clec4d; Dectin-3; Clec4e; MyD88; TLR signalling
资金
- Wellcome Trust [102705]
- Medical Research Council (UK) [MR/J004820/1]
- University of Aberdeen
- MRC [MR/J004820/1] Funding Source: UKRI
The heterodimeric mycobacterial receptors, macrophage C-type lectin (MCL) and macrophage inducible C-type lectin (Mincle), are upregulated at the cell surface following microbial challenge, but the mechanisms underlying this response are unclear. Here we report that microbial stimulation triggers Mincle expression through the myeloid differentiation primary response gene 88 (MyD88) pathway; a process that does not require MCL. Conversely, we show that MCL is constitutively expressed but retained intracellularly until Mincle is induced, whereupon the receptors form heterodimers which are translocated to the cell surface. Thus this two-step model for induction of these key receptors provides new insights into the underlying mechanisms of anti-mycobacterial immunity. (C) 2016 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur.
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