Article
Biotechnology & Applied Microbiology
Yuliya Lokha, Sara Arana-Pena, Nathalia S. Rios, Carmen Mendez-Sanchez, Luciana R. B. Goncalves, Fernando Lopez-Gallego, Roberto Fernandez-Lafuente
ENZYME AND MICROBIAL TECHNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Nicolas Rios-Lombardia, Maria Jesus Rodriguez-Alvarez, Francisco Moris, Robert Kourist, Natalia Comino, Fernando Lopez-Gallego, Javier Gonzalez-Sabin, Joaquin Garcia-Alvarez
FRONTIERS IN CHEMISTRY
(2020)
Article
Chemistry, Physical
Susana Velasco-Lozano, Javier Santiago-Arcos, Jose A. Mayoral, Fernando Lopez-Gallego
Article
Chemistry, Physical
H. A. Macias, L. Yate, E. Coy, W. Aperador, J. J. Olaya
Summary: The influence of deposition parameters on TiWSiN thin films' mechanical properties, wear volume, and corrosion resistance was investigated using a Taguchi L16(45) orthogonal array design. The power applied to the silicon target was found to be the most significant factor affecting the properties of the evaluated films, with nanocomposite and FCC/BCC crystalline structures detected. Columnar growth was observed in almost all films, with column width being influenced by deposition conditions.
APPLIED SURFACE SCIENCE
(2021)
Article
Engineering, Environmental
Emerson Coy, Visnja Babacic, Luis Yate, Karol Zaleski, Yeonho Kim, Juan Sebastian Reparaz, Bernhard Dorling, Bartlomiej Graczykowski, Igor Iatsunskyi, Katarzyna Siuzdak
Summary: Transition metal carbides have gained attention for their high structural and physicochemical properties in energy and electrochemistry applications. Nanostructuring and stoichiometry control of Ta-Hf-C has shown outstanding electrochemical stability, offering new insights for a broad range of applications in energy production, catalysis, and analytical chemistry.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Antonio Lopez-Gay, Jeroen Spijker, Helen V. S. Cole, Antonio G. Marques, Margarita Triguero-Mas, Isabelle Anguelovski, Marc Mari-Dell'Olmo, Juan A. Modenes, Dolores alamo-Junquera, Fernando Lopez-Gallego, Carme Borrell
Summary: This study investigated the relationship between COVID-19 incidence and sociodemographic factors in Barcelona. The findings showed that areas with higher population density, an aged population structure, a high presence of nursing homes, a higher proportion of people who left their residential areas during lockdown, and a higher proportion of people working in health-related occupations were more likely to have a higher number of COVID-19 cases. On the other hand, COVID-19 incidence was negatively associated with the percentage of residents with post-secondary education and the population born in countries with a high Human Development Index.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Luigi Tavernini, Oscar Romero, Carla Aburto, Fernando Lopez-Gallego, Andres Illanes, Lorena Wilson
Summary: Hybrid bioinorganic biocatalysts have drawn much attention for their simple synthesis, high efficiency, and structural features that enhance enzyme activity and stability. In this study, a biomineralization strategy was utilized to form hybrid nanocrystals from beta-galactosidase, showing high specific activity and remarkable thermal stability. This new biocompatible and inexpensive nanobiocatalyst demonstrated promising industrial applications with high enzyme recovery and stability.
Article
Chemistry, Physical
Guillermo Garcia-Marquina, Reyes Nunez-Franco, Francesca Peccati, Yi Tang, Gonzalo Jimenez-Oses, Fernando Lopez-Gallego
Summary: This study reveals that mutation clusters in the acyltransferase LovD9 can enhance enzyme kinetics and stability, providing a theoretical basis for simvastatin synthesis. By combining rational mutation clusters, we successfully generated the variant LovD-BuCh2 with catalytic efficiency close to LovD9.
Article
Chemistry, Multidisciplinary
Lorena Betancor, Fernando Lopez-Gallego
Summary: This review explores the combination of isolated enzymes and whole cells for chemical biomanufacturing. Both isolated enzymes and whole-cell biocatalysis have their own advantages, which can be synergistically utilized to improve efficiency and sustainability in bioprocesses. Different architectural approaches, such as combining extracellular enzymes and microorganisms, displaying enzymes on whole cell walls, and integrating enzymes and microorganisms into different materials, are presented as available alternatives for tandem enzyme-cell systems' biotransformations.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Susana Velasco-Lozano, Javier Santiago-Arcos, Maria Grazia Rubanu, Fernando Lopez-Gallego
Summary: In this study, a cell-free enzyme system with self-sufficient cofactor recycling was used for efficient transformation of aliphatic diols into omega-hydroxy acids. Two compatible alcohol dehydrogenases were selected as specialist biocatalysts to maximize the efficiency of the biosynthetic route. The cell-free system achieved high conversion rates and exhibited excellent enantioselectivity. It also demonstrated superior sustainability compared to traditional metal catalysts and whole cells. Moreover, the system allowed for enzyme reutilization.
Editorial Material
Chemistry, Multidisciplinary
Lorena Betancor, Fernando Lopez-Gallego
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Guillermo Garcia-Marquina, Judith Langer, Mercedes Sanchez-Costa, Gonzalo Jimenez-Oses, Fernando Lopez-Gallego
Summary: This study focuses on optimizing the continuous synthesis of simvastatin by immobilizing an engineered acyltransferase enzyme on controlled porous glass particles functionalized with Fe3+-catechol complexes. The immobilized enzyme showed improved thermal stability and maintained high product yield during multiple operational cycles. Under optimal flow conditions, the system achieved a 100% simvastatin yield with improved reaction mass efficiency and atom economy compared to previous studies.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Eleftheria Diamanti, Susana Velasco-Lozano, Daniel Grajales-Hernandez, Alejandro H. Orrego, Desire Di Silvio, Jose Maria Fraile, Fernando Lopez-Gallego
Summary: Self-sufficient heterogeneous biocatalysts (ssHB) are potential candidates for cofactor-dependent enzymes in chemical biomanufacturing. By immobilizing adenylated cofactors on agarose microbeads through reversible covalent bonds formed between the cis-diol of the ribose in the cofactor backbone and boronic acid, the limitations of current ssHBs in high ionic strength conditions are overcome. The functionality and stability of these ssHBs are demonstrated in reductive aminations, and the immobilized enzymes and cofactors can be reused multiple times.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Physical
Alejandro H. Orrego, Daniel Andres-Sanz, Susana Velasco-Lozano, Mercedes Sanchez-Costa, Jose Berenguer, Jose M. Guisan, Javier Rocha-Martin, Fernando Lopez-Gallego
Summary: The research demonstrates the importance of asymmetric reduction of beta-ketoesters with cell-free enzymes in the synthesis of functional products. By using a novel thermophilic enzyme, it was possible to achieve successful reuse of both the enzyme and co-immobilised cofactor in up to 10 reaction cycles.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Marcos Navascuez, Raquel Gracia, Marco Marradi, Natividad Diaz, Javier Rodriguez, Iraida Loinaz, Fernando Lopez-Gallego, Jordi Llop, Damien Dupin
Summary: In this study, dextran derivatives with hydrophobic or hydrophilic functional groups were evaluated as stabilizers for oil-in-water emulsions. The methacrylate-functionalized dextran showed the most promising results, requiring a minimum amount to achieve stable nanoemulsions that could be degraded by lipases.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
