Article
Gastroenterology & Hepatology
Wei Li, Haitao Xiao, Hong Wu, Xuewen Xu, Yange Zhang
Summary: This study found evidence that exposure to organophosphate pesticides may have adverse effects on biomarkers of liver function and injury, highlighting the potential toxic effect of these pesticides on the human liver.
LIVER INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Yatao Huang, Shuai Li, Youde Wang, Zhiwei Yan, Yachun Guo, Liying Zhang
Summary: In this study, the protective effect of compound 1 against astrocyte H/R injury was investigated by targeting PYGB. Results show that compound 1 does not alleviate astrocytes H/R injury after PYGB knockdown. It also does not improve cellular energy metabolism or inhibit apoptosis-associated protein expression. This study provides new insights into the mechanism of compound 1's efficacy.
Article
Clinical Neurology
Stacy R. Loushin, Courtney Pendleton, Robert J. Spinner, Kenton R. Kaufman
Summary: This study aimed to quantify human exposure to hand-arm vibration from a surgical drill during a simulation of a common spine procedure. Vibration measurements were collected during three 30-second surgical trials on a fresh frozen cadaver torso specimen. The results showed that surgeons reached their exposure limits after a certain period of tool usage.
WORLD NEUROSURGERY
(2022)
Article
Immunology
Abbey Ruhland, Ashley Fell, Stacy M. Holzbauer, Paige D'Heilly, Kris Curtis, Holly Wick, Bree Friedman, Erica Mumm, Malia Ireland, Carrie Estey-Dix, Melissa Betts-Roelike, Amanda Beaudoin
Summary: Healthcare personnel, even when fully vaccinated, are still at risk of getting infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in both occupational and nonoccupational settings. This risk increases during the circulation of the Delta variant. It is crucial to conduct SARS-CoV-2 testing for fully vaccinated healthcare personnel who have worked within 14 days after exposure to prevent the introduction of the virus into healthcare settings.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Jose M. Horcas-Nieto, Christian J. Versloot, Miriam Langelaar-Makkinje, Albert Gerding, Tjasso Blokzijl, Mirjam H. Koster, Mirjam Baanstra, Ingrid A. Martini, Robert P. Coppes, Celine Bourdon, Sven C. D. van Ijzendoorn, Peter Kim, Robert H. J. Bandsma, Barbara M. Bakker
Summary: Hospitalized children with severe malnutrition often suffer from hepatic and intestinal dysfunction, leading to high mortality rates. Our study has established organoid models of severe malnutrition in the liver and intestine, which recapitulate the expected functional changes and protein alterations seen in these organs. By re-supplementing amino acids or using specific drugs, we observed partial recovery of organoid function. These organoid models serve as valuable tools for understanding the underlying mechanisms and testing potential treatments for intestinal and hepatic dysfunction in severe malnutrition.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Gabija Laubner, Indre Straznickaite
Summary: Despite regulations, Lithuanian shooting range workers still show poor understanding of occupational lead exposure prevention, leading to chronic lead poisoning symptoms. Elevated blood lead levels in these workers result in symptoms like fatigue, dizziness, and joint pain.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Reut Falach, Liat Bar-On, Shlomi Lazar, Tamar Kadar, Ohad Mazor, Moshe Aftalion, David Gur, Yentl Evgy, Ohad Shifman, Tamar Aminov, Ofir Israeli, Inbar Cohen-Gihon, Galia Zaide, Hila Gutman, Yaron Vagima, Efi Makdasi, Dana Stein, Ronit Rosenfeld, Ron Alcalay, Eran Zahavy, Haim Levy, Itai Glinert, Amir Ben-Shmuel, Tomer Israely, Sharon Melamed, Boaz Politi, Hagit Achdout, Shmuel Yitzhaki, Chanoch Kronman, Tamar Sabo
Summary: Normally, mice are not affected by SARS-CoV-2, but induced mild pulmonary morbidities in CD-1 mice made them susceptible to the virus. Low doses of lung injury agents caused severe disease in these mice, with high viral RNA levels in the lungs, heart, and serum. The deleterious effects of SARS-CoV-2 infection were alleviated by passive transfer of antibodies against the virus.
Article
Ergonomics
Harold Gomes, Vidisha Parasram, James Collins, Christina Socias-Morales
Summary: This study analyzed the microdata of Occupational Safety and Health Administration's severe injury reports to understand the trends and patterns over time. The results showed a gradual increase and then a decrease in severe injury reports, with more reports in the summer months. The manufacturing and construction industries had the highest number of yearly severe injury reports, with contact with objects and equipment, and falls, slips, trips being the most common injury events.
JOURNAL OF SAFETY RESEARCH
(2023)
Article
Microbiology
Daniel Ho, Kristen D. Kelley, Satya Dandekar, Stuart H. Cohen, George R. Thompson III
Summary: Liver disease compromises the host immune system, making patients more susceptible to invasive fungal diseases. Severe coccidioidomycosis cases were observed in patients with liver dysfunction, leading to increased morbidity and mortality. Collaborative multi-center epidemiologic studies are needed to determine the incidence of severe coccidioidomycosis in patients with concurrent liver disease.
Article
Pharmacology & Pharmacy
Mohammad Alshabeeb, Fadhel A. Alomar, Amjad Khan
Summary: The study did not find an association between the SLCO1B1 rs4149056 (T521C) polymorphism and liver injury induced by flucloxacillin and co-amoxiclav. However, a slightly lower frequency of positive cases was noticed in the flucloxacillin cases compared to the control group.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Wenjie Li, Xingzhou Jiang, Haisheng Qian, Xinyan Li, Jing Su, Guoxin Zhang, Xuan Li
Summary: This study aimed to investigate the relationship between arsenic exposure and liver injury in adults. Using data from the NHANES, urinary arsenic concentrations were measured and markers of liver injury were analyzed. The results showed a positive association between urinary arsenic exposure and liver injury in adults, and sex and smokers may play a role in arsenic pathogenicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, General & Internal
Janett Kreutziger, Margot Fodor, Dagmar Morell-Hofert, Florian Primavesi, Stefan Staettner, Eva-Maria Gassner, Stefan Schmid, Christopher Rugg
Summary: Stress hyperglycemia is common in trauma patients, but in the most severe blunt liver injuries, it may be absent. The study suggests that absence of stress hyperglycemia on hospital admission could be a sign of the most severe liver injury. Blood glucose level changes could potentially serve as an additional diagnostic criterion for grading liver injury.
Article
Chemistry, Multidisciplinary
Mamdouh A. Sofan, Fawzia Z. El-Ablack, Aya I. Elsayed
Summary: The indole motif is an important component in the quest for innovative drugs. Novel N-substituted indole derivatives have shown strong antibacterial and antifungal effects against Candida albicans, comparable to widely used drugs like fluconazole.
Article
Medicine, Research & Experimental
Gao Huan, Yang Tao, Wang Yu, Zhai Jinghui, Zhang Yueming, Song Yanqing
Summary: This study found that the hydrolysate PEP obtained through enzymatic hydrolysis and purification can alleviate organ damage induced by LPS caused by infection. The analysis of plasma metabolites identified seven pathways that may play a critical role in the protection process, involving oxidative stress, energy, and amino acid metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Chen Li, Jinhua Hu, Haibin Su
Summary: This study presented two cases of severe liver injury due to inhalation of 1,2,3-trichloropropane (TCP). The exposure history, toxicology, biochemical index, and pathology confirmed the liver damage. The cases showed acute poisoning symptoms, followed by severe jaundice and coagulation dysfunction. The liver histology revealed severe hepatocyte necrosis, inflammatory cell infiltration, and cholestasis. Recovery was achieved after long-term treatment.
FRONTIERS IN PUBLIC HEALTH
(2023)