Article
Surgery
Joshua Weiner, Alan Hemming, David Levi, Thiago Beduschi, Rei Matsumoto, Abhishek Mathur, Peter Liou, Adam Griesemer, Benjamin Samstein, Daniel Cherqui, Jean Emond, Tomoaki Kato
Summary: This study advocates for the wider utilization of ex vivo liver resection techniques for otherwise unresectable liver tumors. The results show favorable survival rates and demonstrate that the required skillset for ex vivo resection is widespread, with fewer complications than previously assumed.
Article
Infectious Diseases
Ting Sun, Tao Wang, Yiwen Qiu, Shu Shen, Xianwei Yang, Yi Yang, Bin Huang, Wentao Wang
Summary: This study evaluated the risk of major postoperative complications in end-stage HAE patients undergoing ELRA using a sarcopenia score and identified independent risk factors for predicting these complications. The findings provide valuable information for the development of relevant interventions for high-risk patients postoperatively.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Medicine, General & Internal
Charles W. G. Risbey, Carlo Pulitano
Summary: Liver transplantation is a life-saving procedure for patients with end-stage liver disease, but the shortage of donors prevents many patients from receiving transplants. This paper investigates the clinical progress of ex vivo normothermic machine perfusion (NMP) as an alternative preservation technique for liver transplantation in humans.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Mourad Adballah, Yamid Espinel, Lilian Calvet, Bruno Pereira, Bertrand Le Roy, Adrien Bartoli, Emmanuel Buc
Summary: This study revealed that laparoscopic liver resection using augmented reality appears to provide more accurate resection margins with less variability than the gold standard ultrasound navigation, especially in difficult to access liver zones with deep tumors.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Hong Wang, Cheng-Cheng Zhang, Yan-Jiao Ou, Lei-Da Zhang
Summary: The case demonstrates that the application of ex vivo liver resection followed by autotransplantation in radical resection of GCLM can achieve favorable clinical outcomes for selected patients with intrahepatic metastases located in complex sites.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Oncology
Hannah M. Knochelmann, Amalia M. Rivera-Reyes, Megan M. Wyatt, Aubrey S. Smith, Reilley Chamness, Connor J. Dwyer, Michael Bobian, Guillermo O. Rangel Rivera, Joshuva D. Horton, Michael Lilly, Martin J. Romeo, Cynthia D. Timmers, Mark P. Rubinstein, David M. Neskey, Chrystal M. Paulos
Summary: The study found that murine TIL are similar to human TIL in the expression of inhibitory receptors and can be expanded ex vivo, providing a platform for studying TIL across different malignancies. This research will help to draw parallels between mouse and human tumor-infiltrating lymphocytes and evaluate relationships between inhibitory receptor expression and function.
Article
Oncology
Shaoyan Xu, Chenlu Hu, Zedong Jiang, Guogang Li, Bo Zhou, Zhenzhen Gao, Sheng Yan
Summary: This study reports on the liver resection and autotransplantation surgery in 10 cases of malignant hepatobiliary primary cancers or hepatic metastases. The results showed a 100% survival rate one month after surgery, with 9 patients still alive and 7 of them free from cancer recurrence. The study suggests that liver resection and autotransplantation may be a viable treatment option.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Yiwen Qiu, Bin Huang, Xianwei Yang, Tao Wang, Shu Shen, Yi Yang, Wentao Wang
Summary: This study analyzed the benefits and risks of ex vivo liver resection and autotransplantation (ELRA) in end-stage hepatic alveolar echinococcosis (AE). The long-term overall survival of the ELRA group was superior to that of the nonsurgical group, and patients with a predicted 12-month mortality risk >75% would significantly benefit from ELRA.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Surgery
Yiwen Qiu, Xianwei Yang, Bin Huang, Gengfu Wei, Yin Chen, Kangmin Yang, Wentao Wang
Summary: This retrospective study examined the effects of different materials on perioperative outcomes in patients undergoing IVC reconstruction. It was found that the choice of IVC reconstruction material did not significantly affect postoperative outcomes, but artificial materials significantly increased inpatient cost.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Pharmacology & Pharmacy
Matthew Behr, Jing Zhou, Bing Xu, Hongwei Zhang
Summary: CRISPR-Cas9-based genome editing has advanced to human clinical trials within less than a decade, but the low efficiency of in vivo delivery needs to be enhanced in order to fully realize its therapeutic potential.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Gastroenterology & Hepatology
Nerea Zabaleta, Carmen Unzu, Nicholas D. Weber, Gloria Gonzalez-Aseguinolaza
Summary: In this review, the authors discuss gene therapy involving the use of recombinant adeno-associated virus vectors for the treatment of inherited liver diseases, including ongoing clinical trials that are producing promising results. Clinical testing has revealed several key challenges associated with gene therapy, such as the interaction of the immune system with the vector and the risk of adverse events. The permanent modification of the host genome through gene editing raises concerns about oncogenicity and requires careful evaluation.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Surgery
Tomoaki Yoh, Francois Cauchy, Olivier Soubrane
Summary: Laparoscopic liver resection (LLR) has become a popular alternative to conventional open surgery, especially for malignant tumors. While LLR offers short-term benefits such as reduced blood loss and postoperative complications, its oncological benefit depends on technical expertise and adherence to oncological rules. Easy LLRs can be performed by most surgeons, but intermediate or difficult LLRs require expertise and should be done in expert centers. Standardization is important to achieve oncological benefit with LLR.
Article
Surgery
Jiaqi Yuan, Xiaobin Chen, Lizhao Hou, Haijiu Wang, Ying Zhou, Mingquan Pang, CaiRang YangDan, Zhixin Wang, Haining Fan
Summary: This study retrospectively analyzed the clinical and follow-up data of 13 patients with hepatic alveolar echinococcosis. The results showed that Ex vivo Liver Resection and Autotransplantation is an effective treatment for end-stage complicated hepatic alveolar echinococcosis. Precise preoperative assessment, individualized intraoperative duct reconstruction, and precise management of postoperative diseases can achieve better treatment results.
FRONTIERS IN SURGERY
(2023)
Review
Medicine, General & Internal
Claire Goumard, Celia Turco, Mehdi Sakka, Lynda Aoudjehane, Philippe Lesnik, Eric Savier, Filomena Conti, Olivier Scatton
Summary: The ongoing organ shortage has led transplant teams to develop ex-situ machine perfusion as an alternative source for liver grafts. Normothermic machine perfusion has shown promise in defatting livers, with successful results on human organs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Surgery
Alejandro Serrablo, Teresa Gimenez-Maurel, Alejandra Utrilla Fornals, Leyre Serrablo, Daniel Azoulay
Summary: Ex situ liver resection and autotransplantation is a valuable option for patients with conventionally unresectable hepatic tumors and normal liver function. However, there are risks of adverse events and postoperative recurrences. Tumor size and resection range are correlated with surgical outcomes.