Article
Immunology
Xiaofang Xu, Dianhua Qiao, Chenyang Dong, Morgan Mann, Roberto P. Garofalo, Sunduz Keles, Allan R. Brasier
Summary: The SMARCA4 complex is found to play a crucial role in the response of airway epithelial cells to RSV infection, with its depletion leading to cellular state transition and chromatin opening that affect gene expression within cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Article
Medicine, Research & Experimental
Ruihua Jing, Conghui Hu, Tiantian Qi, Jiaqi Yue, Guangyan Wang, Ming Zhang, Chan Wen, Cheng Pei, Bo Ma
Summary: The study revealed that TGF-β2 induced cell apoptosis, which could contribute to EMT and ECM synthesis during PCO. Inhibition of apoptosis-associated protein ZVAD decreased expression of EMT and ECM markers. RNA-seq analysis identified FILIP1L as a key factor in regulating cell migration and EMT/ECM synthesis through apoptosis in PCO. In conclusion, apoptosis mediated by FILIP1L plays a significant role in the development of PCO and can serve as a potential drug target for future treatments.
Article
Biochemistry & Molecular Biology
Yanwen Mao, Xiaohuan Zhang, Wei Peng, Huiming Liu, Xingchen Zhou, Luqun Liang, Jiayi Xiang, Huifang Zhang, Dan Wang, Lingling Liu, Yuxia Zhou, Fan Zhang, Ying Xiao, Mingjun Shi, Yuanyuan Wang, Bing Guo
Summary: EI24 plays a tumor suppressor role in kidney diseases by inhibiting renal interstitial fibrosis through inhibiting epithelial-mesenchymal transition and excessive extracellular matrix deposition, as well as reducing inflammation by restraining NF-kappa B and JNK pathways.
Article
Immunology
Junwei Zhao, Tianci Jiang, Pengfei Li, Lingling Dai, Guang Shi, Xiaogang Jing, Shuhui Gao, Liuqun Jia, Shujun Wu, Yu Wang, Youmei Peng, Zhe Cheng
Summary: The study showed that TF promotes airway pathological features by enhancing the EMT of bronchial epithelial cells in asthma, while downregulation of TF reduces airway hyperresponsiveness, eosinophil inflammation, and EMT process. TF downregulation also inhibits migration and invasion, and decreases fibronectin 1 and TGF-β1 expression while increasing E-cadherin expression in stimulated 16HBE cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Syed Afroz Ali, Mohd Aslam Saifi, Chandraiah Godugu, Venu Talla
Summary: The study demonstrated the anti-fibrotic activity of silibinin in pulmonary fibrosis, alleviating inflammatory response and modulating epithelial-mesenchymal phenotypic alterations.
PHYTOTHERAPY RESEARCH
(2021)
Review
Cell Biology
Pengfei Lu, Yunzhe Lu
Summary: Epithelium is traditionally considered an immotile tissue, but recent research has shown that it is actually more motile than previously thought. Epithelial-mesenchymal transition (EMT) is a crucial process for embryonic development, organ formation, and cancer metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Janne E. Reseland, Catherine A. Heyward, Athina Samara
Summary: Ameloblastin is not only involved in dental enamel formation, but also expressed in different parts of the gastrointestinal tract, potentially playing roles in extracellular matrix structure and tissue integrity, as well as signaling processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Radhika P. Gogoi, Sandra Galoforo, Alexandra Fox, Colton Morris, Harry Ramos, Vir K. Gogoi, Hussein Chehade, Nicholas K. Adzibolosu, Chenjun Shi, Jitao Zhang, Roslyn Tedja, Robert Morris, Ayesha B. Alvero, Gil Mor
Summary: The study identified CTGF as a crucial gene for maintaining the epithelial phenotype and inhibiting EMT. Its loss is associated with early cellular modifications required for EMT.
Article
Immunology
Elodie Riviere, Clara Chivasso, Juliette Pascaud, Rami Bechara, Bineta Ly, Christine Delporte, Xavier Mariette, Gaetane Nocturne
Summary: Salivary gland epithelial cells (SGECs) play an active role in the pathogenesis of primary Sjogren's syndrome (pSS). Hyperosmolar stimulation of SGECs leads to transcriptomic modifications that promote lymphocytic infiltration and extracellular matrix remodeling in the salivary glands.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Claudia Griselda Cardenas-Leon, Kristina Maemets-Allas, Mariliis Klaas, Katre Maasalu, Viljar Jaks
Summary: This study investigated the role of sweat glands in the pathogenesis of Dupuytren's contracture (DC) through proteomic analysis and immunofluorescence microscopy. The researchers found that a fraction of sweat gland epithelium underwent epithelial-mesenchymal transition, and increased connective tissue growth factor expression in DC sweat glands had both autocrine and paracrine effects in sustaining DC formation and inducing pathological changes in DC-associated sweat glands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jing Zhang, Zhimin Hu, Calista A. Horta, Jing Yang
Summary: Epithelial-mesenchymal transition (EMT) is involved in various aspects of tumor development. The tumor microenvironment, consisting of different stroma cells and biochemical factors, influences the EMT program and tumor progression. This review explores the effects of tumor microenvironmental signals on EMT regulation, discusses the molecular mechanisms of EMT in therapy resistance, and proposes new therapeutic approaches targeting the tumor microenvironment to impact EMT and tumor progression.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Angelique Mottais, Luca Riberi, Andrea Falco, Simone Soccal, Sophie Gohy, Virginia De Rose
Summary: Epithelial-to-mesenchymal transition (EMT) is a reversible process where epithelial cells transform into mesenchymal cells. This transformation is seen in various lung diseases, including lung cancer, interstitial lung diseases, asthma, chronic obstructive pulmonary disease, cystic fibrosis, and bronchiectasis. Chronic inflammation in these diseases can lead to aberrant tissue repair, resulting in structural changes and impaired lung function. Understanding the mechanisms underlying EMT may help identify targets for therapeutic interventions to prevent irreversible structural changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jiayida Nulali, Ming Zhan, Kaiwen Zhang, Pinghui Tu, Yu Liu, Huaidong Song
Summary: The extracellular matrix (ECM) is composed of noncellular components and has special properties for influencing cell behavior and tissue structure. Small leucine-rich proteoglycans (SLRPs) are nonfibrillar ECM components that serve as structural scaffolds and signaling molecules. Osteoglycin (OGN), a class III SLRP, is a ubiquitous ECM component that not only helps to organize the extracellular matrix but also regulates a number of important biological processes. In addition to its role in fiber assembly and fibrosis, OGN is also found in cancer tissues and is involved in cellular processes linked to tumorigenesis.
Article
Polymer Science
Anna Ulldemolins, Alicia Jurado, Carolina Herranz-Diez, Nuria Gavara, Jorge Otero, Ramon Farre, Isaac Almendros
Summary: Physiomimetic decellularized extracellular matrix-derived hydrogels are an important source of bioactive vesicles that can modulate lung repair. EVs and ECM-vesicles derived from MSCs and L-HG have similar therapeutic capacity in lung repair, but MSCs-derived EVs show higher therapeutic potential.
