期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 15, 页码 3270-3272出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc09620g
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资金
- BioNano Health-Guard Research Center - Ministry of Science, ICT & Future Planning (MSIP) of Korea as Global Frontier Project [H-GUARD_2013 M3A6B2078950]
- National Research Foundation of Korea (NRF) [NRF-2012R1A1A2043991]
- KRIBB Research Initiative Program, Republic of Korea
- National Research Council of Science & Technology (NST), Republic of Korea [PNK4160] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2013M3A6B2078950] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Gold nanoparticle-conjugated fluorescent hydroxyapatite (AuFHAp) was developed as a smart nanoprobe for measuring alkaline phosphatase (ALP) activity. AuFHAp showed NIR fluorescence due to the hydrolysis of its phosphate groups by ALP. In addition, gold nanoparticles help reduce the nonspecific signal by absorbing nonspecific fluorescence. Through in vitro tests, we confirmed that the AuFHAp probe was capable of detecting ALP levels related to osteoblast activity in living cells with high fluorescence intensity.
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