ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages

ACT001 Ameliorates ionizing radiation-induced lung injury by inhibiting NLRP3 inflammasome pathway

(2023) Hao Luo et al.   BIOMEDICINE & PHARMACOTHERAPY

ACT001 inhibits pituitary tumor growth by inducing autophagic cell death via MEK4/MAPK pathway

(2022) Lin Cai et al.   ACTA PHARMACOLOGICA SINICA

A 4-Benzene-Indol Derivative Alleviates LPS-Induced Acute Lung Injury Through Inhibiting the NLRP3 Inflammasome

(2022) Junmei Li et al.   Frontiers in Immunology

The dynamic interplay between AMPK/NFκB signaling and NLRP3 is a new therapeutic target in inflammation: Emerging role of dapagliflozin in overcoming lipopolysaccharide-mediated lung injury

(2022) Eslam E. Abd El-Fattah et al.   BIOMEDICINE & PHARMACOTHERAPY

NLRP3 inflammasome in cancer and metabolic diseases

(2021) Bhesh Raj Sharma et al.   NATURE IMMUNOLOGY

Macrophages in Lung Injury, Repair, and Fibrosis

(2021) Peiyong Cheng et al.   Cells

Gasdermin D pore structure reveals preferential release of mature interleukin-1

(2021) Shiyu Xia et al.   NATURE

Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease

(2021) Sebastian T Lugg et al.   THORAX

Gasdermin D in pyroptosis

(2021) Brandon Burdette et al.   Acta Pharmaceutica Sinica B

Inhibition of NF-κB by ACT001 reduces fibroblast activity in idiopathic pulmonary fibrosis

(2021) Jade Jaffar et al.   BIOMEDICINE & PHARMACOTHERAPY

PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice

(2021) Rui Xiong et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Ligustrazine Alleviate Acute Lung Injury Through Suppressing Pyroptosis and Apoptosis of Alveolar Macrophages

(2021) Rundong Jiang et al.   Frontiers in Pharmacology

Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo

(2021) Yuhan Liu et al.   INFLAMMATION

A traditional herbal formula, Deng-Shi-Qing-Mai-Tang, regulates TLR4/NF-κB signaling pathway to reduce inflammatory response in PM2.5-induced lung injury

(2021) You Zhou et al.   PHYTOMEDICINE

ACT001 modulates the NF-κB/MnSOD/ROS axis by targeting IKKβ to inhibit glioblastoma cell growth

(2020) Qiuying Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Anticancer Effects of ACT001 via NF-κB Suppression in Murine Triple-Negative Breast Cancer Cell Line 4T1

(2020) Yanyang Liu et al.   Cancer Management and Research

IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation

(2019) Wenjun Ouyang et al.   IMMUNITY

NETs promote ALI/ARDS inflammation by regulating alveolar macrophage polarization

(2019) Chao Song et al.   EXPERIMENTAL CELL RESEARCH

ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma

(2019) Xiaonan Xi et al.   Cell Death & Disease

The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson’s disease in mice

(2019) Qianqian Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Micheliolide alleviates hepatic steatosis in db/db mice by inhibiting inflammation and promoting autophagy via PPAR-γ-mediated NF-кB and AMPK/mTOR signaling

(2018) Juan Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Acute Respiratory Distress Syndrome

(2018) Eddy Fan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia

(2018) Jing Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of telmisartan on TNFα induced PPARγ phosphorylation and insulin resistance in adipocytes

(2018) Tao Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Magnolol ameliorates lipopolysaccharide-induced acute lung injury in rats through PPAR-γ-dependent inhibition of NF-kB activation

(2015) Ming-Hsien Lin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway

(2014) Jing Yao et al.   IMMUNOLOGY

Fate PPAR-titioning: PPAR-γ 'instructs' alveolar macrophage development

(2014) Florent Ginhoux   NATURE IMMUNOLOGY

Pulmonary Macrophage Subpopulations in the Induction and Resolution of Acute Lung Injury

(2012) Laura K. Johnston et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Systemic Analysis of PPAR  in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway Immunity

(2012) E. L. Gautier et al.   JOURNAL OF IMMUNOLOGY

NF-κB in immunobiology

(2011) Matthew S Hayden et al.   CELL RESEARCH