Review
Biochemistry & Molecular Biology
Federica Valentini, Oriana Piermatti, Luigi Vaccaro
Summary: This contribution discusses the use of metal nanoparticles in the formation of C-N bonds and the impact of support materials and metal selection on catalytic activity. Experimental methods to elucidate the active mechanism are described.
Article
Chemistry, Physical
Nahiane Pipaon Fernandez, Gregory Gaube, Kyla J. Woelk, Mathias Burns, Damian P. Hruszkewycz, David C. Leitch
Summary: We present a new method for direct C-C bond formation using tandem C-O/C-H activation mediated by palladium catalyst. This approach allows for base-free direct C-H alkenylation by combining C-O oxidative addition at enol pivalates and concerted metalation-deprotonation of functionalized heterocycles. Mechanistic studies show that C-O oxidative addition is reversible and C-H activation occurs directly from the Pd(II) C-O oxidative addition product. In situ P-31 NMR spectroscopy reveals that (Cy3P)(2)Pd-(alkenyl)(OPiv) species is the predominant catalyst resting state during the reactions.
Article
Chemistry, Organic
Uros Todorovic, Immo Klose, Nuno Maulide
Summary: Thiocyanates, a versatile building block in organic synthesis, can be easily accessed through an interrupted Pummerer reaction of sulfoxides. This dealkylative functionalization can proceed under mild conditions by electrophilic activation of the sulfoxide partner, and the resulting thiocyanate can be used as a handle for diversification in a straightforward one-pot procedure.
Article
Chemistry, Multidisciplinary
Muhammad Asif Iqbal, Le Lu, Hina Mehmood, Ruimao Hua
Summary: This study reports a Cs2CO3-promoted cross-coupling reaction of arenes with cyano-/nitro-substituted aryl halides in DMSO to afford biaryls in the absence of ligands. The cyano/nitro groups in biaryls are shown to be useful for further transformations. Additionally, the formation of dibenzofurans from reactions between arenes and 1-bromo-2-iodobenzene is reported. A radical mechanism for the formation of biaryls is proposed based on control experiments and theoretical studies.
Article
Chemistry, Multidisciplinary
Yongquan Tang, Fang Chen, Sai Wang, Qi Sun, Xiangju Meng, Feng-Shou Xiao
Summary: A porous phenanthroline-based polymer, synthesized via free radical polymerization, exhibits excellent catalytic performance in transition-metal-free C-H arylation reactions, potentially opening up new possibilities for the design of novel heterogeneous transition-metal-free catalysts.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Alvaro Velasco-Rubio, Pol Martinez-Balart, Andres M. Alvarez-Constantino, Martin Fananas-Mastral
Summary: Direct functionalization of alkanes is a significant challenge in developing efficient and clean C-C bond forming reactions due to the low reactivity of aliphatic C-H bonds. Photocatalytic processes using hydrogen atom transfer C-H bond activation strategies have emerged as useful tools to activate and functionalize these inert compounds. This article summarizes the main achievements in this field for developing C-C bond forming reactions and discusses the key mechanistic features enabling these transformations.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Michela L. Maiola, Joshua A. Buss
Summary: We have successfully synthesized low-valent tantalum-copper heterometallic compounds that mimic the structural elements of surface alloyed nanomaterials using a metal-metal salt metathesis strategy. Our study also found that the mechanism of bimetallic assembly can be altered by modifying the ancillary ligands. Additionally, we have synthesized a tetranuclear species with unique Ta-Cu interactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Daigo Hayashi, Tomohiro Tsuda, Ryo Shintani
Summary: A palladium-catalyzed skeletal rearrangement has been developed to synthesize highly fused tetrahydrophenanthrosilole derivatives via bond exchange. The reaction conditions can be tuned to produce different products, fused dihydrodibenzosilepin derivatives.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Xiao-Wen Wang, Rui-Xue Li, Yang Deng, Ming-Qiu-Hao Fu, Ya-Nan Zhao, Zhi Guan, Yan-Hong He
Summary: This article proposes a new method for the direct hydroxylarylation of unactivated benzylic carbons (sp3/sp2/sp) without the need for pre-functionalized benzylic alcohols, aromatic aldehydes, or ketones. It features direct functionalization of unactivated benzylic C(sp3)-H bonds and benzylic sp2/sp-carbons, mild conditions (open air, room temperature), an environmentally friendly procedure (without any external catalyst/mediator/additive), and direct access to sterically hindered alcohols from inexpensive and readily available alkyl/alkenyl/alkynylbenzenes. Mechanistic studies strongly support the proposed radical-radical cross-coupling between transient ketyl radicals and persistent radical anions. Gram-scale synthesis and diversification of drug derivatives demonstrate the practical potential of this protocol.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ke-Xin Wu, Yi-Ze Xu, Liang Cheng, Run-Shi Wu, Peng-Ze Liu, Da-Zhen Xu
Summary: This paper describes a method for directly constructing all-carbon quaternary centers from secondary C(sp(3))-H substrates through a dehydrogenative cross-coupling reaction, using FeCl2 center dot 4H(2)O as the catalyst and air as the terminal oxidant. This method provides 3,3-disubstituted oxindoles bearing all-carbon quaternary centers with excellent chemoselectivities under mild, ligand-free and base-free conditions.
Article
Chemistry, Multidisciplinary
Limei Wang, Yu Sun, Fuyong Zhang, Jingting Hu, Wentao Hu, Shunji Xie, Yongke Wang, Jun Feng, Yubing Li, Genyuan Wang, Biao Zhang, Haiyan Wang, Qinghong Zhang, Ye Wang
Summary: Despite numerous studies on photocatalysis, there has been limited success in using semiconductors to synthesize industrially important bulk chemicals. However, this study successfully designed and fabricated single-atom rhodium-doped nanorods, which showed record-breaking efficiencies in producing ethylene glycol, a key bulk chemical used for polyester manufacturing, through photocatalysis.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Applied
Shanping Chen, Kai Hu, Wei Feng, Guojiang Mao, Yuxia Li, Guo-Jun Deng
Summary: A direct strategy for the synthesis of fused thienoindoles from substituted indoles and elemental sulfur has been reported. This method yields a range of structurally valuable fused thienoindoles in 51-78% yield under transition-metal-free conditions, potentially useful in pharmaceutical industry and organic functional materials.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Daniel Eppel, Alpay Eryigit, Matthias Rudolph, Margit Brueckner, Frank Rominger, Abdullah M. Asiri, A. Stephen K. Hashmi
Summary: Starting from a [(C-MeO<^>N<^>C)AuCl] complex as precursor, a direct substitution by C,H-activation from sp-, sp(2)- or sp(3)-C,H-bonds under basic conditions in a planetary ball mill was achieved. This protocol provides an easy access to a highly valued complex class with extraordinary photophysical properties without the need for pre-functionalization of the starting materials or expensive transition metal catalysts, making it appealing for industrial purposes. The methodology was also successfully applied to chelate type [(tpy)AuCl2] complexes, demonstrating its versatility.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Jakub Brzeskiewicz, Rafal Loska
Summary: The palladium-catalyzed C(sp2)-H functionalization of bromoaryl aldonitrones leading to benzocyclobutenone-derived ketonitrones is described, allowing for the preparation of a wide range of strained, four-membered ketonitrones with broad functional group tolerance. Downstream transformations of the formed products were demonstrated, illustrating the synthetic utility of the obtained benzocyclobutenone-derived nitrones for the construction of polycyclic nitrogen-containing scaffolds.
Article
Chemistry, Multidisciplinary
Toshiro Takao, Yuta Takahashi, Masataka Kai
Summary: This article investigates the reaction of a triruthenium complex with ammonia, leading to the synthesis of an azaruthenacyclopentadiene skeleton through the scission and formation of N-H and C-N bonds.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Chi Zhang, Qiang Sun, Huihui Kong, Chunxue Yuan, Wei Xu
SCIENCE CHINA-CHEMISTRY
(2019)
Article
Chemistry, Physical
Yuanqi Ding, Xinyi Wang, Donglin Li, Wei Xu
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Article
Chemistry, Physical
Hui Lu, E. Wenlong, Liangliang Cai, Zhibo Ma, Wei Xu, Xueming Yang
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Multidisciplinary
Xin Yu, Xin Li, Haiping Lin, Mengxi Liu, Liangliang Cai, Xia Qiu, Dandan Yang, Xing Fan, Xiaohui Qiu, Wei Xu
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Lei Xie, Huijun Jiang, Donglin Li, Mengxi Liu, Yuanqi Ding, Yufang Liu, Xin Li, Xuechao Li, Haiming Zhang, Zhonghuai Hou, Yi Luo, Lifeng Chi, Xiaohui Qiu, Wei Xu
Article
Chemistry, Physical
Donglin Li, Yuanqi Ding, Xinyi Wang, Wei Xu
Summary: 2D-MOFs incorporating different noncovalent interactions and multiple metal components are complex and less predictable, but a systematic study can enhance our fundamental understanding of the interaction mechanism of noncovalent bonds and lead to further investigations into the unique functions of surface-supported 2D-MOF structures.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Donglin Li, Luye Sun, Yuanqi Ding, Mengxi Liu, Lei Xie, Yinfu Liu, Lina Shang, Yangfan Wu, Hui-Jun Jiang, Lifeng Chi, Xiaohui Qiu, Wei Xu
Summary: This study focuses on the role of water molecules in driving chiral separation on the surface when RNA base uracil selfassembles into homochiral structures upon water exposure. The findings provide insights into the general role of water molecules in the origin of homochirality in living systems, with implications for other biologically relevant molecules such as amino acids and sugars.
Article
Chemistry, Multidisciplinary
Yuanqi Ding, Lei Xie, Donglin Li, Hanlin Shen, Cuiyu Li, Wei Xu
Summary: Based on STM imaging and DFT calculations, this study provides experimental evidence of the interconversion between G-quartets and G-triads on the Au(111) surface, and reveals the relative stabilities of these two motifs, which enhances the fundamental understanding of the relationship between G-triplex and G-quadruplex DNA structures.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Xin Yu, Qiang Sun, Mengxi Liu, Wan Du, Yi Liu, Liangliang Cai, Zeqi Zha, Jinliang Pan, Faming Kang, Wenze Gao, Dandan Yang, Xiaohui Qiu, Wei Xu
Summary: On-surface synthesis is a promising strategy for constructing novel carbon-based nanostructures. In this study, the on-surface reactions of 1,1,2,2-tetraiodoethylene and 1,1,4,4-tetrabromo-1,2,3-butatriene were systematically explored. The results showed the feasibility of achieving acetylenic and diacetylenic organometallic polyyne on Ag(110) and Cu(110) surfaces, respectively. The transformation between different structures after annealing indicated a lattice dependence of skeleton reconstruction on the corresponding surfaces.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Physical
Faming Kang, Wenze Gao, Liangliang Cai, Cuiyu Li, Chunxue Yuan, Wei Xu
Summary: On-surface synthesis has shown advantages in precise fabrication of surface-supported nanostructures, particularly when introducing the alkenyl gem-dibromide group. Selective on-surface reactions, such as homocoupling and hydrogen migration, were achieved on Ag(111) and Ag(110) surfaces, respectively, with lattice-directed selectivity revealed by extensive DFT calculations. This lattice-directed strategy is crucial for steering on-surface reaction pathways towards atomically precise synthesis with high efficiency and selectivity.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Review
Chemistry, Multidisciplinary
Lina Shang, Faming Kang, Wenze Gao, Zheng Zhou, Wei Xu
Summary: The on-surface synthesis of carbon nanostructures has gained significant attention due to their unique properties and wide range of applications. Recent studies have focused on low-dimensional sp-carbon nanostructures, which exhibit structural linearity, small steric demands, and intriguing electronic and mechanical properties.
Article
Chemistry, Multidisciplinary
Lei Xie, Yuanqi Ding, Donglin Li, Chi Zhang, Yangfan Wu, Luye Sun, Mengxi Liu, Xiaohui Qiu, Wei Xu
Summary: Water plays a crucial role in biological self-assembly processes, and studying the interactions between water and organic molecules can provide insights into the mechanisms of biological self-assembly.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Multidisciplinary
Chi Zhang, Wei Xu
Summary: Understanding the interactions between water and organic molecules or inorganic salts is crucial for studying hydration processes in chemistry. This review provides new insights into these interactions using scanning probe microscopy and theoretical calculations. The study reveals the important role of water in biological self-assembly processes and its ability to assist structural transformation in nanostructures.
Article
Chemistry, Multidisciplinary
Xin Yu, Liangliang Cai, Meiling Bao, Qiang Sun, Honghong Ma, Chunxue Yuan, Wei Xu
CHEMICAL COMMUNICATIONS
(2020)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)