Coordinating nucleoporin condensation and nuclear pore complex assembly

A quantitative map of nuclear pore assembly reveals two distinct mechanisms

(2023) Shotaro Otsuka et al.   NATURE

LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion

(2023) Yaiza Jung-Garcia et al.   NATURE CELL BIOLOGY

Improving the hole picture: towards a consensus on the mechanism of nuclear transport

(2023) David Cowburn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nucleoporin foci are stress‐sensitive condensates dispensable for C. elegans nuclear pore assembly

(2023) Laura Thomas et al.   EMBO JOURNAL

Visualizing the disordered nuclear transport machinery in situ

(2023) Miao Yu et al.   NATURE

Phase separation of intrinsically disordered FG-Nups is driven by highly dynamic FG motifs

(2023) Maurice Dekker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Barrier properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length

(2023) Sheung Chun Ng et al.   Nature Communications

Co-translational binding of importins to nascent proteins

(2023) Maximilian Seidel et al.   Nature Communications

Ribosomal Protein uS5 and Friends: Protein–Protein Interactions Involved in Ribosome Assembly and Beyond

(2023) Anne-Marie Landry-Voyer et al.   Biomolecules

Comprehensive structure and functional adaptations of the yeast nuclear pore complex

(2022) Christopher W. Akey et al.   CELL

Karyopherin enrichment and compensation fortifies the nuclear pore complex against nucleocytoplasmic leakage

(2022) Joanna Kalita et al.   JOURNAL OF CELL BIOLOGY

Karyopherin-mediated nucleocytoplasmic transport

(2022) Casey E. Wing et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A perinuclear α-helix with amphipathic features in Brl1 promotes NPC assembly

(2022) Jlenia Vitale et al.   MOLECULAR BIOLOGY OF THE CELL

Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains

(2022) Eszter E. Najbauer et al.   Nature Communications

Co-translational assembly orchestrates competing biogenesis pathways

(2022) Maximilian Seidel et al.   Nature Communications

The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth

(2022) Elisa Dultz et al.   Cells

Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold

(2022) Pietro Fontana et al.   SCIENCE

Architecture of the cytoplasmic face of the nuclear pore

(2022) Christopher J. Bley et al.   SCIENCE

Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex

(2022) Xuechen Zhu et al.   SCIENCE

Architecture of the linker-scaffold in the nuclear pore

(2022) Stefan Petrovic et al.   SCIENCE

AI-based structure prediction empowers integrative structural analysis of human nuclear pores

(2022) Shyamal Mosalaganti et al.   SCIENCE

Quality control mechanisms that protect nuclear envelope identity and function

(2022) Philip J. Mannino et al.   JOURNAL OF CELL BIOLOGY

Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities

(2022) Sarah M. Prophet et al.   NATURE CELL BIOLOGY

The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis

(2022) E. F. Elsiena Kuiper et al.   NATURE CELL BIOLOGY

Molecular interactions of FG nucleoporin repeats at high resolution

(2022) Alain Ibáñez de Opakua et al.   Nature Chemistry

An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae

(2022) Annemarie Kralt et al.   eLife

Recessive NUP54 Variants Underlie Early‐Onset Dystonia with Striatal Lesions

(2022) Philip Harrer et al.   ANNALS OF NEUROLOGY

Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation

(2022) Weimin Shen et al.   CELL

Direct binding of ESCRT protein Chm7 to phosphatidic acid–rich membranes at nuclear envelope herniations

(2021) David J. Thaller et al.   JOURNAL OF CELL BIOLOGY

Disease modeling with human neurons reveals LMNB1 dysregulation underlying DYT1 dystonia

(2021) Baojin Ding et al.   JOURNAL OF NEUROSCIENCE

CNS critical periods: implications for dystonia and other neurodevelopmental disorders

(2021) Jay Li et al.   JCI Insight

On the asymmetric partitioning of nucleocytoplasmic transport – recent insights and open questions

(2021) Joanna Kalita et al.   JOURNAL OF CELL SCIENCE

Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis

(2021) Ophélie Lautier et al.   MOLECULAR CELL

Mitotic disassembly and reassembly of nuclear pore complexes

(2021) Ulrike Kutay et al.   TRENDS IN CELL BIOLOGY

The cellular environment shapes the nuclear pore complex architecture

(2021) Anthony P. Schuller et al.   NATURE

A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis

(2021) Wanlu Zhang et al.   Open Biology

Dunking into the Lipid Bilayer: How Direct Membrane Binding of Nucleoporins Can Contribute to Nuclear Pore Complex Structure and Assembly

(2021) Mohamed Hamed et al.   Cells

Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2

(2020) Anthony J. Rampello et al.   JOURNAL OF CELL BIOLOGY

The Role of Torsin AAA+ Proteins in Preserving Nuclear Envelope Integrity and Safeguarding Against Disease

(2020) Anthony J. Rampello et al.   Biomolecules

Lipid and protein dynamics that shape nuclear envelope identity

(2020) Shirin Bahmanyar et al.   MOLECULAR BIOLOGY OF THE CELL

Nucleo–cytoplasmic transport defects and protein aggregates in neurodegeneration

(2020) Giacomo Bitetto et al.   Translational Neurodegeneration

Maturation Kinetics of a Multiprotein Complex Revealed by Metabolic Labeling

(2020) Evgeny Onischenko et al.   CELL

Dissecting the Structural Dynamics of the Nuclear Pore Complex

(2020) Zhanna Hakhverdyan et al.   MOLECULAR CELL

Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions

(2020) Saskia Hutten et al.   Cell Reports

Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1

(2020) Naemi Luithle et al.   eLife

Advances in molecular and cell biology of dystonia: Focus on torsinA

(2019) Pedro Gonzalez-Alegre   NEUROBIOLOGY OF DISEASE

Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

(2019) Irina L Rempel et al.   eLife

Nanocompartmentalization of the Nuclear Pore Lumen

(2019) Kai Huang et al.   BIOPHYSICAL JOURNAL

Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis

(2019) Bernhard Hampoelz et al.   CELL

Fantastic nuclear envelope herniations and where to find them

(2018) David J. Thaller et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Surface Properties Determining Passage Rates of Proteins through Nuclear Pores

(2018) Steffen Frey et al.   CELL

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

(2018) Takuya Yoshizawa et al.   CELL

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

(2018) Mario Hofweber et al.   CELL

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

(2018) Lin Guo et al.   CELL

Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis

(2018) Wanlu Zhang et al.   JOURNAL OF CELL BIOLOGY

Building a complex complex: Assembly of mitochondrial respiratory chain complex I

(2018) Luke E. Formosa et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Integrative structure and functional anatomy of a nuclear pore complex

(2018) Seung Joong Kim et al.   NATURE

Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells

(2018) Brandon H. Toyama et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of nuclear pore complex assembly - two different ways of building one molecular machine

(2017) Shotaro Otsuka et al.   FEBS LETTERS

TorsinA dysfunction causes persistent neuronal nuclear pore defects

(2017) Samuel S Pappas et al.   HUMAN MOLECULAR GENETICS

Karyopherins regulate nuclear pore complex barrier and transport function

(2017) Larisa E. Kapinos et al.   JOURNAL OF CELL BIOLOGY

Proteasome Structure and Assembly

(2017) Lauren Budenholzer et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanisms and functions of nuclear envelope remodelling

(2017) Rosemarie Ungricht et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport

(2017) Fatima Gasset-Rosa et al.   NEURON

Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors

(2017) Iker Valle Aramburu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The roles of the nuclear pore complex in cellular dysfunction, aging and disease

(2017) Stephen Sakuma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pre-assembled Nuclear Pores Insert into the Nuclear Envelope during Early Development

(2016) Bernhard Hampoelz et al.   CELL

Nucleoporin genes in human diseases

(2016) Valeria Nofrini et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Simple rules for passive diffusion through the nuclear pore complex

(2016) Benjamin L. Timney et al.   JOURNAL OF CELL BIOLOGY

Dissecting Torsin/cofactor function at the nuclear envelope: a genetic study

(2016) Ethan Laudermilch et al.   MOLECULAR BIOLOGY OF THE CELL

Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles

(2016) H. Broder Schmidt et al.   TRENDS IN BIOCHEMICAL SCIENCES

Neuronal Nuclear Membrane Budding Occurs during a Developmental Window Modulated by Torsin Paralogs

(2016) Lauren M. Tanabe et al.   Cell Reports

Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia

(2016) F Esra Demircioglu et al.   eLife

Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope

(2016) Shotaro Otsuka et al.   eLife

Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors

(2015) Sigrid Milles et al.   CELL

Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly

(2015) Benjamin Vollmer et al.   DEVELOPMENTAL CELL

Nuclear Pore Basket Proteins Are Tethered to the Nuclear Envelope and Can Regulate Membrane Curvature

(2015) Noémi Mészáros et al.   DEVELOPMENTAL CELL

Size-dependent leak of soluble and membrane proteins through the yeast nuclear pore complex

(2015) Petra Popken et al.   MOLECULAR BIOLOGY OF THE CELL

A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import

(2015) Michael J. W. VanGompel et al.   MOLECULAR BIOLOGY OF THE CELL

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

(2015) Ke Zhang et al.   NATURE

The molecular mechanism of nuclear transport revealed by atomic-scale measurements

(2015) Loren E Hough et al.   eLife

Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity

(2015) Hermann Broder Schmidt et al.   eLife

Karyopherin-Centric Control of Nuclear Pores Based on Molecular Occupancy and Kinetic Analysis of Multivalent Binding with FG Nucleoporins

(2014) Larisa E. Kapinos et al.   BIOPHYSICAL JOURNAL

The mechanism of Torsin ATPase activation

(2014) Rebecca S. H. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How lamina-associated polypeptide 1 (LAP1) activates Torsin

(2014) Brian A Sosa et al.   eLife

The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1

(2013) Paolo Colombi et al.   JOURNAL OF CELL BIOLOGY

Regulation of Torsin ATPases by LAP1 and LULL1

(2013) C. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Torsin Mediates Primary Envelopment of Large Ribonucleoprotein Granules at the Nuclear Envelope

(2013) Vahbiz Jokhi et al.   Cell Reports

Dimerization and direct membrane interaction of Nup53 contribute to nuclear pore complex assembly

(2012) Benjamin Vollmer et al.   EMBO JOURNAL

Facilitated aggregation of FG nucleoporins under molecular crowding conditions

(2012) Sigrid Milles et al.   EMBO REPORTS

POM121 and Sun1 play a role in early steps of interphase NPC assembly

(2011) Jessica A. Talamas et al.   JOURNAL OF CELL BIOLOGY

Localization of Pom121 to the inner nuclear membrane is required for an early step of interphase nuclear pore complex assembly

(2011) Tomoko Funakoshi et al.   MOLECULAR BIOLOGY OF THE CELL

Cell Cycle-Dependent Differences in Nuclear Pore Complex Assembly in Metazoa

(2010) Christine M. Doucet et al.   CELL

Nuclear pore biogenesis into an intact nuclear envelope

(2010) Christine M. Doucet et al.   CHROMOSOMA

A Unique Redox-sensing Sensor II Motif in TorsinA Plays a Critical Role in Nucleotide and Partner Binding

(2010) Li Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Bimodal Distribution of Two Distinct Categories of Intrinsically Disordered Structures with Separate Functions in FG Nucleoporins

(2010) Justin Yamada et al.   MOLECULAR & CELLULAR PROTEOMICS

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells

(2009) Maximiliano A. D'Angelo et al.   CELL

FG/FxFG as well as GLFG repeats form a selective permeability barrier with self-healing properties

(2009) Steffen Frey et al.   EMBO JOURNAL

Characterisation of the passive permeability barrier of nuclear pore complexes

(2009) Dagmar Mohr et al.   EMBO JOURNAL

Flexible Gates: Dynamic Topologies and Functions for FG Nucleoporins in Nucleocytoplasmic Transport

(2009) Laura J. Terry et al.   EUKARYOTIC CELL

Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA

(2009) M. Jungwirth et al.   HUMAN MOLECULAR GENETICS

Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulum

(2009) C. A. Hodge et al.   JOURNAL OF CELL SCIENCE

Capture of AT-rich Chromatin by ELYS Recruits POM121 and NDC1 to Initiate Nuclear Pore Assembly

(2008) Beth A. Rasala et al.   MOLECULAR BIOLOGY OF THE CELL

Artificial nanopores that mimic the transport selectivity of the nuclear pore complex

(2008) Tijana Jovanovic-Talisman et al.   NATURE