Structure‐based design of peptidomimetic inhibitors of PSD‐95 with improved affinity for the PDZ3 domain

A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman syndrome

(2023) Kara A. Lau et al.   PROGRESS IN NEUROBIOLOGY

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

(2021) Plinio C. Casarotto et al.   CELL

Major Depression: One Brain, One Disease, One Set of Intertwined Processes

(2021) Elena V. Filatova et al.   Cells

In silico identification and design of potent peptide inhibitors against PDZ-3 domain of Postsynaptic Density Protein (PSD-95)

(2018) Tanuj Sharma et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus

(2018) John Marshall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection

(2017) Cristy Phillips   NEURAL PLASTICITY

TrkB-enhancer facilitates functional recovery after traumatic brain injury

(2017) John Marshall et al.   Scientific Reports

Origins of Allostery and Evolvability in Proteins: A Case Study

(2016) Arjun S. Raman et al.   CELL

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity

(2016) Menglong Zeng et al.   CELL

A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density

(2016) Ward G Walkup et al.   eLife

Inhibition ofN-Methyl-d-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential

(2015) John Marshall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Ketamine in Treatment-Resistant Depression: A Systematic Review

(2014) Gianluca Serafini et al.   Current Neuropharmacology

The Epidemiology of Depression Across Cultures

(2013) Ronald C. Kessler et al.   Annual Review of Public Health

Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome

(2013) Cong Cao et al.   PLOS BIOLOGY

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

(2012) A. Bach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

PDZ domains and their binding partners: structure, specificity, and modification

(2010) Ho-Jin Lee et al.   Cell Communication and Signaling

A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia

(2010) B.W. LeBlanc et al.   NEUROSCIENCE

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

Hidden dynamic allostery in a PDZ domain

(2009) C. M. Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Chemical Library Approach to Organic‐Modified Peptide Ligands for PDZ Domain Proteins: A Synthetic, Thermodynamic and Structural Investigation

(2008) D. Gomika Udugamasooriya et al.   CHEMBIOCHEM