Article
Medicine, General & Internal
Yaling Zhang, Dejian Chen, Daojuan Wang, Lei Wang, Yajing Weng, Hongwei Wang, Xiaoke Wu, Yong Wang
Summary: This study investigates the effects of moderate aerobic exercise on follicle development in PCOS-like rats. The results show that aerobic exercise not only reverses the PCOS phenotype, but also activates the BDNF-TrkB pathway to inhibit apoptosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
James M. Fay, Chaemin Lim, Anna Finkelstein, Elena Batrakova, Alexander Kabanov
Summary: The study introduced two novel formulations replacing PEG in therapeutic polyion complexes, demonstrating that encapsulation does not inhibit receptor kinase access, enhancing the physiological benefits of BDNF.
Article
Clinical Neurology
Leo Sher, Linda M. Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda
Summary: This study found that plasma BDNF levels were higher among combat veterans who made suicide attempts post-deployment compared to those who did not. BDNF may be involved in the pathophysiology of suicidal behavior in this population.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Cell Biology
Feng Zhou, Lipeng Chen, Shan Xu, Caijuan Si, Nan Li, Hui Dong, Peifen Zheng, Weifeng Wang
Summary: This study revealed that miR-151-5p plays a crucial role in the development of UC by inhibiting BNDF expression, leading to apoptosis and reduced viability of UC cells. Treatment with exogenous BNDF reversed the effects of miR-151-5p, providing a potential new direction for UC therapy.
Article
Neurosciences
Wioletta Kazana, Dominika Jakubczyk, Jakub Siednienko, Aleksandra Zambrowicz, Jozefa Macala, Agnieszka Zablocka
Summary: In this study, it was found that yolkin, a polypeptide complex derived from hen egg yolk, can promote the proliferation of rat hippocampal precursor cells and upregulate the expression of BDNF through a CREB-dependent pathway. The upregulation of CREB phosphorylation by yolkin is dependent on the activation of cAMP/PKA and PI3K/Akt signaling pathways. These findings suggest that yolkin may play a comprehensive role in regulating neuronal survival and activity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Shintaro Yamaguchi, Ryo Isaka, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi
Summary: Research has found that silver nanoparticles with a diameter of 10 nm can inhibit retinoic acid-induced neuronal differentiation. This inhibitory effect may be achieved through the oxidative stress pathway, induction of mitochondrial ROS production, and decreased expression of mitochondrial fusion-related genes.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Hossein Babaei, Alireza Kheirollah, Mina Ranjbaran, Maryam Cheraghzadeh, Alireza Sarkaki, Maryam Adelipour
Summary: The study suggests that preconditioning mesenchymal stem cells (MSCs) with dimethyl fumarate (DMF) enhances their therapeutic efficacy in treating neurodegenerative disorders, including Alzheimer's disease (AD). In vitro experiments showed that DMF increased the survival and antioxidant capacity of MSCs. In an AD rat model, DMF-preconditioned MSC transplantation improved learning and spatial memory deficits, decreased apoptotic marker expression, and increased neurotrophin expression in the hippocampus.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biology
Andonia Petkova-Tuffy, Nina Goedecke, Julio Viotti, Martin Korte, Thomas Dresbach
Summary: The study reveals that NL1 and BDNF act together to play a crucial role in synaptic maturation, including increasing the stability of active zones and recycling of synaptic vesicles, a process that relies on a transsynaptic pathway between them. Using BDNF can mimic the effects of NL1 overexpression on structural and functional maturation, while blocking BDNF signaling can prevent the effects of NL1 on presynaptic maturation.
Article
Multidisciplinary Sciences
Panetha Pansri, Phetcharat Phanthong, Nopparat Suthprasertporn, Yindee Kitiyanant, Alisa Tubsuwan, Andras Dinnyes, Julianna Kobolak, Narisorn Kitiyanant
Summary: The study found that BDNF can promote cell proliferation of AD-derived hNPCs, but does not have a promoting effect on neurite outgrowth. The JAK2 inhibitor AG490 partially decreased BDNF-induced cell proliferation.
Article
Multidisciplinary Sciences
Carlos Berlanga-Macias, Mairena Sanchez-Lopez, Montserrat Solera-Martinez, Ana Diez-Fernandez, Inmaculada Ballesteros-Yanez, Carlos A. Castillo-Sarmiento, Isabel A. Martinez-Ortega, Vicente Martinez-Vizcaino
Summary: This study found no significant positive association between exclusive breastfeeding and BDNF serum levels in Spanish schoolchildren aged eight to 11 years. Regardless of breastfeeding duration, age group, or sexual maturation, BDNF levels did not show significant differences, indicating that exclusive breastfeeding may not have a significant impact on BDNF levels in this age group.
Article
Cell & Tissue Engineering
Mitsuki Kadono, Ayumu Nakashima, Naoki Ishiuchi, Kensuke Sasaki, Yoshie Miura, Satoshi Maeda, Asuka Fujita, Ayano Sasaki, Shogo Nagamatsu, Takao Masaki
Summary: This study found that mesenchymal stem cells cultured in serum-free medium (SF-MSCs) showed better effects in improving renal function and inhibiting apoptosis in a contrast-induced nephropathy (CIN) mouse model. In addition, SF-MSCs demonstrated stronger inhibitory effects on apoptosis in irradiated HEK-293 cells. The secretion of epidermal growth factor (EGF) by SF-MSCs may contribute to their anti-apoptotic effects.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Behavioral Sciences
Ya-Hai Wang, Huan-Huan Zhou, Qiang Luo, Sidong Cui
Summary: This study investigated the effects of physical exercise on brain-derived neurotrophic factor (BDNF) in healthy individuals. The findings showed that both acute and long-term exercise had significant positive effects on circulating BDNF levels. Subgroup analysis revealed that long-term aerobic exercise, female participants, participants older than 60 years, and aerobic exercise contributed to a more pronounced improvement in BDNF levels.
BRAIN AND BEHAVIOR
(2022)
Review
Neurosciences
Lina Gao, Yun Zhang, Keenan Sterling, Weihong Song
Summary: Synaptic abnormalities are a key aspect of Alzheimer's disease, connecting pathological changes to cognitive impairment. Brain-derived neurotrophic factors are crucial in synaptic plasticity for learning and memory, and have potential as diagnostic biomarkers and therapeutic molecules for AD. The exact mechanisms underlying the effects of impaired BDNF signaling on AD are still unclear.
TRANSLATIONAL NEURODEGENERATION
(2022)
Article
Nutrition & Dietetics
Pallavi Gurung, Rajeev Shrestha, Junmo Lim, Til Bahadur Thapa Magar, Han-Hyuk Kim, Yong-Wan Kim
Summary: The therapeutic and preventive effects of Euonymus alatus twig extract were investigated in a mouse model of cognitive deficit and B35 cells. The extract significantly improved the passive avoidance test in mice, restored the cholinergic systems and the BDNF/ERK/CREB pathway, and inhibited acetylcholine esterase activity in B35 cells.
Review
Clinical Neurology
Sarah K. Ashcroft, Daniel D. Ironside, Liam Johnson, Suzanne S. Kuys, Angelica G. Thompson-Butel
Summary: This systematic review and meta-analysis of 17 studies found that high intensity aerobic exercise can increase circulating BDNF concentrations, which may contribute to increased neuroplasticity in individuals poststroke.
Article
Medicine, General & Internal
Siresha Bathina, Undurti N. Das
ARCHIVES OF MEDICAL SCIENCE
(2015)
Correction
Endocrinology & Metabolism
Siresha Bathina, Nanduri Srinivas, Undurti N. Das
METABOLISM-CLINICAL AND EXPERIMENTAL
(2016)
Article
Biochemistry & Molecular Biology
Siresha Bathina, Undurti N. Das
LIPIDS IN HEALTH AND DISEASE
(2018)
Article
Multidisciplinary Sciences
Sailaja Polavarapu, Arul M. Mani, Naveen K. V. Gundala, Anasuya D. Hari, Siresha Bathina, Undurti N. Das
Article
Biochemistry & Molecular Biology
Siresha Bathina, Undurti N. Das
LIPIDS IN HEALTH AND DISEASE
(2019)
Article
Medicine, Research & Experimental
Siresha Bathina, Naveen K. Gundala, Poorani Rhenghachar, Sailaja Polavarapu, Anasuya D. Hari, Monika Sadananda, Undurti N. Das
ARCHIVES OF MEDICAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Siresha Bathina, Undurti N. Das
Summary: RVD1 can prevent STZ-induced type 1 diabetes by its anti-apoptotic, anti-inflammatory, and antioxidant actions and by activating the Pdx gene that is needed for pancreatic beta cell proliferation. The study results suggest that RVD1 can alleviate the severity of type 1 diabetes through multiple pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Elliot Ballato, Fnu Deepika, Mia Prado, Vittoria Russo, Virginia Fuenmayor, Siresha Bathina, Dennis T. Villareal, Clifford Qualls, Reina Armamento-Villareal
Summary: This study aimed to investigate the impact of glycemic control on circulating osteogenic progenitor (COP) cells and osteoclast precursors (OCP), as well as identify other potential factors. The results showed that individuals with poor long-term glycemic control had a significantly higher percentage of COP, which was positively correlated with visceral adipose tissue volume and negatively correlated with free testosterone and osteocalcin levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Siresha Bathina, Tumininu S. Faniyan, Lauren Bainbridge, Autumn Davis, Kavaljit H. Chhabra
Summary: The role of beta-cell Glut2 in regulating insulin secretion and blood glucose levels in mice was investigated in this study. Knocking down Glut2 specifically in beta-cells did not affect glucose-stimulated insulin secretion and systemic glucose homeostasis in mice.
Review
Biochemistry & Molecular Biology
Fnu Deepika, Siresha Bathina, Reina Armamento-Villareal
Summary: The burden of obesity and osteoporosis is increasing and becoming a major public health concern. Recent evidence has identified novel adipokines that play a role in bone metabolism. Obesity, characterized by adipose tissue inflammation, negatively impacts bone health. Adipokines secreted from white adipose tissue and bone marrow adipose tissue have effects on osteoblasts and osteoclasts. Understanding the complex interplay between fat cells and bone is crucial in the context of osteoporosis. This review summarizes recent advances in the understanding of adipokines' role in bone metabolism.
Article
Endocrinology & Metabolism
Kavaljit H. Chhabra, Siresha Bathina, Tumininu S. Faniyan, Dennis J. Samuel, Muhammad Ummear Raza, Leticia Maria de Souza Cordeiro, Gonzalo Viana Di Prisco, Brady K. Atwood, Jorge Robles, Lauren Bainbridge, Autumn Davis
Summary: This study identifies ADGRL1 as a glucose receptor in the mouse hypothalamus, which is involved in energy and glucose homeostasis in a sex-dependent manner. Targeting ADGRL1 may lead to the development of new drugs for the treatment of type 2 diabetes and obesity.
Review
Endocrinology & Metabolism
Siresha Bathina, Reina Armamento-Villareal
Summary: Fractures associated with Type 2 diabetes (T2DM) are a public health concern in an obese and aging population. Patients with T2DM have normal or better bone mineral density but are at a higher risk for fractures. The main issue in T2DM is a reduction in bone formation due to dysfunction in osteoblast differentiation and survival. Obesity and T2DM are also associated with increased adipogenesis, potentially at the expense of reduced osteogenesis and myogenesis. Understanding the complex mechanisms involved in bone pathophysiology in obesity and T2DM is important for developing pharmacological targets to improve bone health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Siresha Bathina, Nanduri Srinivas, Undurti N. Das
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)