Review
Allergy
Thomas B. Casale
Summary: Chronic idiopathic/spontaneous urticaria (CIU/CSU) has a significant impact on the quality of life and current treatments are ineffective for a certain percentage of patients. Therefore, novel therapeutic agents targeting the pathogenesis of urticaria are needed.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Kanokvalai Kulthanan, Martin K. Church, Eva Maria Grekowitz, Tomasz Hawro, Lea Alice Kiefer, Kanyalak Munprom, Yanisorn Nanchaipruek, Chuda Rujitharanawong, Dorothea Terhorst-Molawi, Marcus Maurer
Summary: The study systematically reviewed a large number of literature and found that histamine plays a key role in the pathogenesis of chronic inducible urticaria, but it is not the sole mediator.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Allergy
Torsten Zuberbier, Jonathan A. Bernstein, Marcus Maurer
Summary: Urticaria is an inflammatory disorder that has been recently updated and revised in the international guidelines, aiming to assist healthcare professionals in managing patients. The guidelines were developed using the Delphi conference and the Grading of Recommendations Assessment Development and Evaluations approach.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Cristina Segu-Verges, Jessica Gomez, Pau Terradas-Montana, Laura Artigas, Serge Smeets, Marta Ferrer, Sinisa Savic
Summary: Chronic spontaneous urticaria (CSU) is a rare and severely debilitating skin disease. This study used systems biology and machine learning to create a CSU interactome model and identified the mechanism of action of different therapeutic strategies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Allen Kaplan, Mark Lebwohl, Ana M. Gimenez-Arnau, Michihiro Hide, April W. Armstrong, Marcus Maurer
Summary: Chronic spontaneous urticaria (CSU) is a debilitating skin disease characterized by intense itchiness and recurrent wheals and angioedema. The inflammatory profiles of CSU patients' skin indicate interactions between mast cells, eosinophils, and basophils, leading to symptoms. Current therapies provide symptomatic relief but do not address the underlying skin inflammation permanently. Understanding the pathogenesis of CSU can lead to the development of targeted treatments with curative intent.
Review
Immunology
Bingjing Zhou, Jie Li, Runqiu Liu, Lei Zhu, Cong Peng
Summary: This article summarizes the latest research progress on the crosstalk between mast cells and other immune cells, providing impetus for the development of treatment strategies for chronic spontaneous urticaria.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matanis Lobna, Eiza Nasren, Sabag Adi, Bejar Jacob, Gimenez-Arnau Ana Maria, Maurer Marcus, Vadasz Zahava
Summary: Sema5A is highly expressed in the skin of patients with chronic spontaneous urticaria (CSU), which may drive the expression and effects of IL-17A. Further studies are needed to confirm the role of Sema5A in the pathogenesis of CSU.
Review
Allergy
Pavel Kolkhir, Melba Munoz, Riccardo Asero, Marta Ferrer, Emek Kocaturk, Martin Metz, Yi-Kui Xiang, Marcus Maurer
Summary: Chronic spontaneous urticaria (CSU) is a mast cell-driven disease characterized by recurrent wheals and/or angioedema, with two main autoimmune mechanisms: type I autoallergic CSU and type IIb autoimmune CSU. The latter is less common but more severe, and new targeted therapies are under development for CSU treatment.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Allergy
Peter Valent, Cem Akin, Karin Hartmann, Andreas Reiter, Jason Gotlib, Karl Sotlar, Wolfgang R. Sperr, Lina Degenfeld-Schonburg, Dubravka Smiljkovic, Massimo Triggiani, Hans-Peter Horny, Michel Arock, Stephen J. Galli, Dean D. Metcalfe
Summary: Mast cell activation plays a crucial role in allergic reactions, inflammatory states, and mast cell activation syndromes. While there is currently no treatment approach to eradicate mast cells, long-term use of drugs that inhibit KIT function may lead to a decrease in tissue mast cells and improvement in symptoms. For patients with KIT D816V-positive mastocytosis, effective KIT inhibitors like avapritinib may be used for mast cell eradication, but potential side effects need to be considered.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Xiaobin Fang, Yueyi Weng, Xiaochun Zheng
Summary: Chronic spontaneous urticaria (CSU), a mast cell-driven disease, significantly affects quality of life. This study identified key genetic factors associated with mast cell activation in CSU and investigated their roles in CSU pathogenesis. Genes involved in chemokine (C-C motif) ligand 2 (CCL2), cholesterol 25-hydroxylase (CH25H), and tumor necrosis factor (TNF) signaling pathways were found to play crucial roles in CSU pathogenesis, and targeting them may provide potential therapeutic options for CSU.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Yi-Kui Xiang, Pavel Kolkhir, Jorg Scheffel, Merle Sauer, Carolina Vera, Stefan Frischbutter, Karoline Krause, Frank Siebenhaar, Martin Metz, Marcus Maurer, Sabine Altrichter
Summary: This study investigated the rates of two subtypes of chronic spontaneous urticaria (CSU), autoallergic chronic spontaneous urticaria (aaCSU) and autoimmune chronic spontaneous urticaria (aiCSU), in CSU patients. Among 111 CSU patients, 58% had aaCSU and 8% had aiCSU. Furthermore, the coexistence of aiCSU and aaCSU needs further research.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Review
Medicine, Research & Experimental
Carmen-Teodora Dobrican, Ioana Adriana Muntean, Irena Pintea, Carina Petricau, Diana-Mihaela Deleanu, Gabriela Adriana Filip
Summary: Chronic urticaria is a chronic skin condition characterized by itching, swelling, and redness lasting for more than 6 weeks. It has a significant socio-economic burden and limited treatment options for severe cases. The pathogenesis of the disease is not fully understood, but mast cells and their activation have been identified as key events in chronic spontaneous urticaria. There is ongoing debate regarding the triggering events and complexity of the effector mechanisms. Other proposed pathogenic mechanisms include the high-affinity IgE receptor-mediated response and the imbalance of the cytokine-chemokine network resulting from alteration of innate immune response. These different mechanisms are likely interconnected and contribute to the clinical expression of chronic urticaria. Understanding these pathogenic mechanisms is crucial for the development of effective treatments.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Allergy
Yudi Chen, Miao Yu, Xiaojie Huang, Ping Tu, Peikun Shi, Marcus Maurer, Zuotao Zhao
Summary: Omalizumab is highly effective in patients with difficult-to-treat CSU, CIndU, or both. Responders tend to have unique immunologic features and longer treatment periods. Patients with higher baseline total IgE levels and longer disease durations are more likely to experience rapid relapse after discontinuation of omalizumab.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Allergy
Marcus Maurer, William Berger, Ana Gimenez-Arnau, Koremasa Hayama, Vipul Jain, Adam Reich, Sibylle Haemmerle, Karine Lheritier, Pauline Walsh, Summer Xia, Julian Storim
Summary: Remibrutinib is highly effective in the treatment of CSU, with rapid onset of action and a favorable safety profile.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Ioana Adriana Muntean, Irena Pintea, Ioana Corina Bocsan, Carmen Teodora Dobrican, Diana Deleanu
Summary: The study found that COVID-19 disease can result in the exacerbation of chronic spontaneous urticaria, more likely in moderate to severe forms of infection.