Article
Plant Sciences
Xiangyang Xu, Genqiao Li, Guihua Bai, Amy Bernardo, Brett F. Carver, Paul St Amand, Ruolin Bian
Summary: Leaf rust, a common wheat disease in the Great Plains of the United States, was studied using recombinant inbred lines from 'Bainong 418' and CI 17884. Two resistant genes, QLr.stars-1RS and Lr47, were identified, with the latter being particularly effective in the region. Development of specific markers facilitates the introgression of these resistance genes into locally adapted wheat cultivars and breeding lines.
Article
Oncology
Rahmina Meta, Henning B. Boldt, Bjarne W. Kristensen, Felix Sahm, Wenche Sjursen, Sverre H. Torp
Summary: Genome-wide DNA methylation profiling is a useful tool in diagnosing meningiomas, but methodological adjustments are needed for further improvement.
Article
Genetics & Heredity
Rui Zheng, Yan Wang, Yaqian Li, Juncen Guo, Yuting Wen, Chuan Jiang, Yihong Yang, Ying Shen
Summary: Loss-of-function mutations in FSIP2 result in multiple morphological abnormalities of the flagella in humans and mice. Our study revealed that FSIP2 might involve in sperm acrosome development, and its mutations might contribute to globozoospermia or acrosomal aplasia. We also uncovered the potential molecular mechanism of FSIP2 regulating acrosome biogenesis.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Genetics & Heredity
Emily P. McCann, Lyndal Henden, Jennifer A. Fifita, Katharine Y. Zhang, Natalie Grima, Denis C. Bauer, Sandrine Chan Moi Fat, Natalie A. Twine, Roger Pamphlett, Matthew C. Kiernan, Dominic B. Rowe, Kelly L. Williams, Ian P. Blair
Summary: A study involving 757 sporadic ALS cases from Australia identified 43 ALS-implicated variants from 18 genes, with about one-third of cases carrying at least one variant. Oligogenic/polygenic sporadic ALS cases showed earlier age of onset.
JOURNAL OF MEDICAL GENETICS
(2021)
Article
Engineering, Environmental
Susanne Van den Berg-Stein, Hans Juergen Hahn, Anne Thielsch, Klaus Schwenk
Summary: Groundwater is a crucial resource, but its ecosystems are understudied. Challenges in studying groundwater organisms include difficulty in accessing species, lack of morphological differentiation, and limitations in laboratory cultures. Genetic methods offer a valuable approach for understanding biodiversity, population structure, and gene flow in natural populations.
Article
Urology & Nephrology
Ping Zhu, Qi Qiu, Peter C. Harris, Xiaolei Xu, Xueying Lin
Summary: Adult zebrafish with tmem67 mutation exhibit progressive mesonephric cysts similar to mammalian cystogenesis, with reduced distal single cilia and increased multi-ciliated cells. Inhibition of mTOR signaling ameliorates renal cysts in both embryonic and adult zebrafish, but only rescues ciliary abnormalities in the adult mutants.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Wajid Syed, Osama A. A. Samarkandi, Ahmed Alsadoun, Mohammad K. Al Harbi, Mahmood Basil A. Al-Rawi
Summary: This study assessed the clinical knowledge and perceptions of healthcare students in Saudi Arabia regarding thyroid cancer (TC). The findings showed that half of the healthcare students had sufficient knowledge about TC, with female participants being more knowledgeable than male participants. The study suggests arranging awareness programs for students to bridge the knowledge gap.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Sajad Najafi, Seyed Mohsen Aghaei Zarch, Jamal Majidpoor, Safoora Pordel, Shahin Aghamiri, Mohammed Fatih Rasul, Yahya Asemani, Omid Vakili, Vida Mohammadi, Ahmad Movahedpour, Nahid Arghiani
Summary: Circular RNAs (circRNAs) are a new class of non-coding RNAs with a closed loop structure, resistant to degrading enzymes, and suggested to have regulatory roles in gene expression. In the human brain, circRNAs show abundance, dynamic expression, and regulation, and are believed to be involved in brain functions and related diseases. They have demonstrated differential expression in brain compartments and contribute to CNS development. Additionally, circRNAs are associated with key pathways involved in brain development, such as axon guidance and signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
News Item
Multidisciplinary Sciences
Michael Marshall
Summary: Biologists are studying how tiny timekeepers in our cells may affect body size, lifespan, and aging.
Article
Microbiology
Ingeborg Becker, Haydee Miranda-Ortiz, Edith A. Fernandez-Figueroa, Sokani Sanchez-Montes, Pablo Colunga-Salas, Estefania Grostieta, Javier Juarez-Gabriel, Yokomi N. Lozano-Sardaneta, Minerva Arce-Fonseca, Olivia Rodriguez-Morales, Gabriela Meneses-Ruiz, Sergio Pasten-Sanchez, Irma Lopez Martinez, Saul Gonzalez-Guzman, Vladimir Paredes-Cervantes, Otacilio C. Moreira, Paula Finamore-Araujo, Julio C. Canseco-Mendez, Uriel Coquis-Navarrete, Laura Rengifo-Correa, Constantino Gonzalez-Salazar, Myrna M. Alfaro-Cortes, Jorge A. Falcon-Lezama, Roberto Tapia-Conyer, Christopher R. Stephens
Summary: This study evaluated the genetic diversity and structure of Tc24 in Triatoma cruzi isolates from Mexico, and found that there is low genetic variability in this region. This information suggests the potential development of in silico strategies for the production of antigens to optimize the diagnosis of Chagas disease.
Letter
Clinical Neurology
Nina Asheim Birkeland, Viel Nyborg Carlsen, Sasha Gulati, Emil K. Gustavsson, Jan O. Aasly
Summary: A patient with Parkinson's disease initially rejected for DBS due to extensive brain calcifications underwent successful surgery after seeking a second opinion. Genetic analysis revealed a mutation in the SLC20A2 gene, known to cause brain calcifications, but no known PD-causing mutation.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Biochemical Research Methods
Maria A. Zelenova, Ivan Y. Iourov
Summary: This study reviews existing CNV interpretation software and algorithms, finding that open and user-friendly CNV interpretation software is limited and the data basis for algorithms seems insufficient. The study concludes that it is necessary to expand the existing algorithms, including pathway and expression data, and develop a user-friendly and freely available CNV interpretation software.
CURRENT BIOINFORMATICS
(2022)
Article
Genetics & Heredity
Suzanne E. de Bruijn, Jeroen J. Smits, Chang Liu, Cornelis P. Lanting, Andy J. Beynon, Joelle Blankevoort, Jaap Oostrik, Wouter Koole, Erik de Vrieze, Cor W. R. J. Cremers, Frans P. M. Cremers, Susanne Roosing, Helger G. Yntema, Henricus P. M. Kunst, Bo Zhao, Ronald J. E. Pennings, Hannie Kremer
Summary: Adult-onset progressive hearing loss is highly heritable and has been identified in 12 families in the Netherlands as an autosomal dominant trait. A 12-nucleotide in-frame deletion in the RIPOR2 gene was found to be a significant cause of this type of hearing loss, affecting protein localization in cochlear hair cells and morphology.
JOURNAL OF MEDICAL GENETICS
(2021)
Review
Plant Sciences
Takayuki Kohchi, Katsuyuki T. Yamato, Kimitsune Ishizaki, Shohei Yamaoka, Ryuichi Nishihama
Summary: Bryophytes hold a fundamental position in the evolution of land plants, with the gametophyte generation dominating their life cycle and offering advantages in genetic research. The liverwort Marchantia polymorpha has become a preferred model organism for studying plant eco-evo-devo biology, revealing both the conservation of key developmental genes and lineage-specific evolution. It is suggested that M. polymorpha is an excellent platform for uncovering the conserved and diversified mechanisms underlying land plant development.
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 72, 2021
(2021)
Review
Genetics & Heredity
Wei Dong, Yue Huang
Summary: This review investigates the comorbidity of Alzheimer's disease and ischemic stroke, and identifies thirteen common risk genes, but no common risk SNPs. The study summarizes the common molecular pathways associated with these risk genes, including inflammation and immunity, G protein-coupled receptor, and signal transduction. At least seven of these genes can be regulated by 23 microRNAs. The findings shed light on the pathogenesis of comorbidity and provide molecular targets for disease prevention and brain health maintenance.
