Mechanisms of landiolol-mediated positive inotropy in critical care settings

PurposeTo present the potential mechanisms by which landiolol enhances a positive inotropic response in critically ill patients.MethodsAnalysis of preclinical, animal, and clinical data to provide novel knowledge and translate research findings into potential clinical application.ResultsThe super-selective beta 1-antagonist landiolol may increase inotropy and may be associated with positive outcomes in critically ill patients with acute decompensated heart failure or sepsis.ConclusionThis review sheds light on the potential mechanisms by which landiolol enhances a positive inotropic response, potentially alleviating the long-held concern over possible negative hemodynamic effects in critically ill patients.

Automated summary

This study investigates the potential mechanisms by which landiolol enhances a positive inotropic response in critically ill patients, highlighting its possible positive outcomes in acute decompensated heart failure or sepsis patients. This sheds new light on the long-held concern over the negative hemodynamic effects in critically ill patients and offers a potential solution.