Article
Endocrinology & Metabolism
Estifanos N. Habtemichael, Don T. Li, Joao Paulo Camporez, Xavier O. Westergaard, Chloe Sales, Xinran Liu, Francesc Lopez-Giraldez, Stephen G. DeVries, Hanbing Li, Diana M. Ruiz, Kenny Y. Wang, Bhavesh S. Sayal, Sofia Gonzalez Zapata, Pamela Dann, Stacey N. Brown, Sandro Hirabara, Daniel F. Vatner, Leigh Goedeke, William Philbrick, Gerald Shulman, Jonathan S. Bogan
Summary: Insulin-stimulated TUG cleavage pathway regulates gene expression to promote lipid oxidation and thermogenesis, linking glucose uptake to organismal energy expenditure. Attenuation of this mechanism may promote obesity as it contributes to the thermic effect of food.
Article
Nutrition & Dietetics
Kieran Shay Struebin Abbotts, Taylor Russell Ewell, Hannah Michelle Butterklee, Matthew Charles Bomar, Natalie Akagi, Gregory P. Dooley, Christopher Bell
Summary: The study found significant pharmacokinetic differences between commercial CBD formulations, CBD is unlikely to affect the caloric cost of eating, but may benefit initial metabolic responses, consuming CBD with food alters the dynamics of CBD metabolism and increases systemic availability, low-dose CBD may not pose a risk to normal liver function.
Article
Endocrinology & Metabolism
Sonar Soni Panigoro, Noorwati Sutandyo, Fiastuti Witjaksono, Nurjati Chairani Siregar, Ramadhan Ramli, Ririn Hariani, Eko Adhi Pangarsa, Yan Wisnu Prajoko, Niken Puruhita, William Hamdani, Dimas Bayu, Mardiana Madjid, Dedy Yulidar, Jane Estherina Fransiska, Retno Widyawati, Effif Syofra Tripriadi, F. W. Wiwit Ade, Dewi Krisna Yunda, Raymond Pranata
Summary: The study revealed a nonlinear dose-response association between TyG index and breast cancer risk, showing that higher TyG index was linked to an increased risk of breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qianhui Zeng, Nannan Wang, Yaru Zhang, Yuxuan Yang, Shuangshuang Li, Rong Zheng, Jin Chai, Tong Qiao, Siwen Jiang
Summary: The study demonstrates that Zfp217 plays a modulatory role in energy metabolism and may offer new insights into obesity treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Kirstin A. MacGregor, Iain J. Gallagher, Colin N. Moran
Summary: This study investigated the variation in insulin sensitivity across the menstrual cycle and found that it is influenced by body mass index (BMI), physical activity, and cardiorespiratory fitness (CRF). Rhythmicity in insulin sensitivity and associated metabolites were modified by these factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Anxin Wang, Guangyao Wang, Qian Liu, Yingting Zuo, Shuohua Chen, Boni Tao, Xue Tian, Penglian Wang, Xia Meng, Shouling Wu, Yongjun Wang, Yilong Wang
Summary: Elevated levels of both baseline and long-term updated cumulative average TyG index can independently predict stroke and ischemic stroke but not intracerebral hemorrhage in the general population during an 11-year follow-up. The study found a linear association between TyG index and stroke outcomes, with higher TyG index associated with increased risk of stroke.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Clinical Neurology
Yoo Jeong Lee, Sooyeon Lee, In Cheol Hwang, Hong Yup Ahn
Summary: This study investigated the relationship between insulin resistance and suicidal ideation, and found that the TyG index was significantly associated with suicidal ideation in women, especially in the low-risk group for suicide.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Endocrinology & Metabolism
Xiaojie He, Xinyue Huang, Yafang Qian, Ting Sun
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common metabolic disorder associated with insulin resistance (IR). A novel index of IR called triglyceride glucose waist circumference (TyG-WC) reflects both visceral fat and hepatic steatosis. In this study, the relationship between TyG-WC and NAFLD in Japanese subjects with normal plasma glucose level was examined, and the threshold level of TyG-WC associated with NAFLD was determined.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jennifer D. Deem, Bao Anh Phan, Kayoko Ogimoto, Alice Cheng, Caeley L. Bryan, Jarrad M. Scarlett, Michael W. Schwartz, Gregory J. Morton
Summary: When mammals are exposed to a warm environment, the activation of specific neurons in the hypothalamic preoptic area (POA(Pacap) neurons) is associated with reduced energy expenditure and glucose intolerance. However, inhibiting the activation of these neurons does not completely eliminate heat-induced impairment of glucose tolerance.
Review
Cardiac & Cardiovascular Systems
Li-Chan Tao, Jia-ni Xu, Ting-ting Wang, Fei Hua, Jian-Jun Li
Summary: This review summarizes the history of the use of the TyG index as a surrogate marker for insulin resistance (IR) and explores its application value in various types of cardiovascular disease (CVD), as well as the potential limitations of using this index as a predictor for cardiovascular events. The aim is to provide more extensive and precise supporting evidence to improve its application value in CVD.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, Research & Experimental
Alan C. Rupp, Abigail J. Tomlinson, Alison H. Affinati, Warren T. Yacawych, Allison M. Duensing, Cadence True, Sarah R. Lindsley, Melissa A. Kirigiti, Alexander MacKenzie, Joseph Polex-Wolf, Chien Li, Lotte Bjerre Knudsen, Randy J. Seeley, David P. Olson, Paul Kievit, Martin G. Myers Jr
Summary: The study found that the adipose-derived hormone leptin controls food intake and body weight by acting on a specific group of GABAergic hypothalamic neurons through its receptor LepRb. This group of neurons shows conservation across species.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Neurosciences
Rodrigo S. Carraro, Guilherme A. Nogueira, Davi Sidarta-Oliveira, Rodrigo S. Gaspar, Nathalia R. Dragano, Joseane Morari, Vanessa C. D. Bobbo, Eliana P. Araujo, Natalia F. Mendes, Ariane M. Zanesco, Natalia Tobar, Celso D. Ramos, Jessica M. Toscaro, Marcio C. Bajgelman, Licio A. Velloso
Summary: NHLH2 is a hypothalamic transcription factor that plays a role in energy homeostasis and obesity. Overexpression of NHLH2 in mice can prevent and reduce obesity by affecting caloric intake.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Hind A. Beydoun, Ted K. S. Ng, May A. Beydoun, Aladdin H. Shadyab, Su Yon Jung, Christy Costanian, Nazmus Saquib, Farha S. Ikramuddin, Kathy Pan, Alan B. Zonderman, JoAnn E. Manson
Summary: This study found that obesity and central obesity markers were associated with COVID-19 outcomes among postmenopausal women, and glucose concentration and TyG partly mediated these associations.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Huijie Huang, Ai Wang, Li Cong, Yingjuan Zeng
Summary: This study investigated the association between osteocalcin and insulin resistance in men with type 2 diabetes. The results showed an inverse correlation between osteocalcin and the TyG index, particularly in younger patients with lower BMI, poorer glycemic control, without hypertension or smoking.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Zhaoxiang Wang, Han Qian, Shao Zhong, Tian Gu, Mengjiao Xu, Qichao Yang
Summary: The purpose of this study was to investigate the relationship between the triglyceride-glucose (TyG) index and albuminuria in the adult population in the United States. The study found that there was a positive correlation between TyG index and albuminuria, which persisted even after adjusting for other factors. In addition, the TyG index was compared with insulin resistance and metabolic syndrome, and it was found that TyG index had a better predictive effect. Subgroup analysis showed that the relationship between TyG index and albuminuria was more significant in terms of age, weight, diabetes, and metabolic syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)