Article
Biophysics
Giorgio Davico, David G. Lloyd, Christopher P. Carty, Bryce A. Killen, Daniel Devaprakash, Claudio Pizzolato
Summary: Model personalization is crucial for accurately estimating internal biomechanical quantities, with personalization of musculoskeletal anatomy and muscle activation patterns having the largest effect overall.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Neurosciences
Jeonghoon Oh, Christopher Kuenze, Joseph F. Signorile, Michael S. Andersen, Michael Letter, Thomas M. Best, Zachary Ripic, Christopher Emerson, Moataz Eltoukhy
Summary: This study developed a practical laboratory setup using a single depth sensor-driven full-body musculoskeletal gait model to assess ground reaction forces during stair climbing for patients following ACL reconstruction. The findings demonstrated that this approach could be a cost-effective alternative tool in clinical settings for individuals who had undergone ACL reconstruction surgery.
Article
Biophysics
Momoko Yamagata, Masashi Taniguchi, Hiroshige Tateuchi, Masashi Kobayashi, Noriaki Ichihashi
Summary: This study revealed that patients with severe symptomatic knee osteoarthritis had significantly higher KAM and medial knee contact force (KCF) compared to those with mild symptoms, along with a significant medial shift of KCF in severe symptomatic patients.
JOURNAL OF BIOMECHANICS
(2021)
Article
Biotechnology & Applied Microbiology
Jeheon Moon, Dohoon Koo, Sungmin Kim, Siddhartha Bikram Panday
Summary: The study aimed to investigate the impact of increased sprinting velocity on ACL load, knee joint load, and activation of femoral muscles using musculoskeletal modeling. Results showed that ACL load, knee joint adduction, and internal rotation moment increased with sidestep cutting velocity, significantly higher than during sprinting at a similar velocity. The co-contraction index of femoral muscles decreased with increasing sprinting velocity during sidestep cutting, while no significant differences were observed during running at different sprinting conditions. Factors such as knee joint shear force, extended landing posture, internal rotation moment, and femoral muscle activity imbalance were suggested to influence the increase of ACL load during a sidestep cutting maneuver.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Di Ao, Geng Li, Mohammad S. Shourijeh, Carolynn Patten, Benjamin J. Fregly
Summary: The study developed a novel method for personalizing OpenSim cylindrical wrapping surfaces during EMG-driven model calibration. The method used two-level polynomial surrogate models to reduce the computational cost and achieved good results in reducing lower extremity joint moment matching errors and improving the prediction of hip joint contact force.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Physiology
Ting Long, Justin Fernandez, Hui Liu, Hanjun Li
Summary: This study aimed to evaluate the risk of knee osteoarthritis following unilateral anterior cruciate ligament reconstruction (ACLR) by comparing the difference in bilateral tibial contact force during walking and jogging using an EMG-assisted method. The results showed that patients had higher tibial compression force on the healthy side than on the surgical side during jogging, possibly due to insufficient activation of the rectus femoris and vastus medialis.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Orthopedics
Troy Blackburn, Darin A. Padua, Brian Pietrosimone, Todd A. Schwartz, Jeffrey T. Spang, Jonathan S. Goodwin, Derek R. Dewig, Chris D. Johnston
Summary: This study evaluated the effects of whole-body vibration (WBV) and local muscle vibration (LMV) on gait biomechanics in individuals with ACLR. LMV decreased the vGRF loading rate significantly, while WBV increased the peak internal knee extension moment. These findings suggest that vibration has the potential to mitigate aberrant gait biomechanics and reduce the risk of posttraumatic knee osteoarthritis following ACLR.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Engineering, Biomedical
Moon Ki Jung, Silvia Muceli, Camila Rodrigues, Alvaro Megia-Garcia, Alejandro Pascual-Valdunciel, Antonio J. Del-Ama, Angel Gil-Agudo, Juan C. Moreno, Filipe Oliveira Barroso, Jose L. Pons, Dario Farina
Summary: This study compared the performance of surface EMG and intramuscular EMG in estimating the required joint torques for assistive devices. The results showed that there was a similar correlation between the experimental and predicted joint torques when using either surface or intramuscular EMG as input signals in both healthy individuals and SCI patients.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Medicine, General & Internal
Clodagh M. Toomey, Jackie L. Whittaker, Luz Palacios-Derflingher, Carolyn A. Emery
Summary: This study shows that individuals with youth sport knee injuries, beyond ACL or meniscus injury, may also experience significant pain and symptoms 3-12 years following injury. Further replication and follow-up are needed to identify potential clinical trajectory towards osteoarthritis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Rebecca J. Spatholt, Chelsea E. Minoughan, Cynthia Gooch, Samuel P. Harms, Michal L. Taylor, Marc T. Galloway, Jason T. Shearn
Summary: Our current understanding of knee mechanics and ACL function is limited to data recorded during simulations or nonphysiologic loads. This study quantified the effects of activity level on knee mechanics and ACL forces during in vivo motions, providing valuable information for ACL reconstruction techniques.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Carola F. van Eck, Tomomasa Nakamura, Taylor Price, Monica Linde, Patrick Smolinski
Summary: In a combined ACL-reconstruction-MCL-repair model, MCL Repair augmented with suture tape improved valgus and external rotation laxity when compared to MCL suture repair alone. The addition of suture tape may provide additional means of stabilization without over-constraining the knee joint, leading to potentially lower failure rates and faster recovery times.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Engineering, Biomedical
Junjun Zhu, Weimin Zhu, Qijie Zhao
Summary: This study aimed to evaluate the position of the graft within the femoral tunnel and the force exerted on the graft under external loads in ACL reconstruction. The model showed that the graft shifted within the femoral tunnel during flexion and under external loads. The anterior region of the tunnel aperture was under significantly more contact force from the graft, potentially leading to tunnel enlargement.
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK
(2023)
Article
Orthopedics
Florian B. Imhoff, Brendan Comer, Elifho Obopilwe, Knut Beitzel, Robert A. Arciero, Julian T. Mehl
Summary: This study aimed to investigate the impact of osteotomy on ACL-deficient and ACL-reconstructed knees, and the results showed that combined varus and slope correction significantly decreased anterior tibial translation and ACL graft forces. Therefore, the importance of alignment in ACL repair surgery has been further validated.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
J. R. Williams, K. Neal, A. Alfayyadh, J. J. Capin, A. Khandha, K. Manal, L. Snyder-Mackler, T. S. Buchanan
Summary: The study evaluated patellofemoral cartilage health 24-months after ACL reconstruction (ACLR) using quantitative magnetic resonance imaging (qMRI) and assessed its association with patellofemoral contact forces and knee mechanics during gait 3 months after surgery. The results showed prolonged T2 relaxation times in the involved limb's trochlear cartilage, indicating worse cartilage health. No differences were found in the patellar cartilage, and significant negative associations were observed between the biomechanical variables of interest and trochlear T2 relaxation times at 24-months in the involved limb.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
Pouya Amiri, Elysia M. Davis, Jereme Outerleys, Ross H. Miller, Scott Brandon, Janie L. Astephen Wilson
Summary: This study investigated the differences in tibiofemoral joint contact forces between individuals with moderate medial OA who experienced radiographic knee OA progression within 3 years and those who did not. Higher tibiofemoral joint contact forces during walking were associated with three-year radiographic knee OA progression based on medial joint space narrowing. Strategies that reduce compressive knee contact forces through the reduction of adduction and flexion moments during walking are needed.
Article
Orthopedics
Nicholas J. Murphy, Laura E. Diamond, Kim L. Bennell, Alexander Burns, Edward Dickenson, Jillian Eyles, Camdon Fary, Stuart M. Grieve, Damian R. Griffin, Young Jo Kim, James M. Linklater, David G. Lloyd, Robert Molnar, Rachel L. O'Connell, John O'Donnell, Sunny Randhawa, Parminder J. Singh, Libby Spiers, Phong Tran, Tim Wrigley, David J. Hunter
Summary: The age of symptom onset in femoroacetabular impingement syndrome (FAIS) is mainly predicted by the measurement of femoral and acetabular morphology, while symptom severity is predominantly determined by patient factors. The measured factors explained only a small amount of variance in the data, suggesting that there may be other unmeasured factors that have a greater influence on the condition.
Article
Medicine, General & Internal
Jodie A. Wills, David J. Saxby, Daniel J. Glassbrook, Timothy L. A. Doyle
Summary: This study aimed to identify and characterize sex-specific physical and psychophysical performance adaptations in response to a novel 10-week training program. The findings showed that the training significantly improved physical performance and psychophysical responses in males, but not in females. The results highlighted the importance of considering sex-specific training to optimize load carriage performance.
Article
Orthopedics
William du Moulin, Matthew Bourne, Laura E. Diamond, Jason Konrath, Christopher Vertullo, David Lloyd, David J. Saxby
Summary: The study aimed to investigate the differences in shape and regional morphology of the semitendinosus (ST) muscle in young adults following anterior cruciate ligament reconstruction (ACLR) compared to healthy controls. The results showed significant shape differences and deviations in the ST muscle of the ACLR group, particularly in the distal region. Additionally, the ACLR group had smaller peak cross-sectional area and volume in the proximal and middle regions of the ST muscle compared to the healthy controls. Shape analysis provides unique insight into regional adaptations in ST morphology post-ACLR.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Sport Sciences
Basilio A. M. Goncalves, David J. Saxby, Evy Meinders, Andrea Hams, Conor Lambert, Taryn Jones, Rod S. Barrett, Laura E. Diamond
Summary: There is no difference in running biomechanics and strength changes after repeated sprint exercise between individuals with FAIS and asymptomatic individuals with and without cam morphology. Self-reported pain does not appear to affect biomechanics during running or strength after repeated sprint exercise in individuals with FAIS.
SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
(2023)
Article
Anatomy & Morphology
Adam Kositsky, Huub Maas, Rod S. Barrett, Ben Kennedy, Lauri Stenroth, Rami K. Korhonen, Christopher J. Vertullo, Laura E. Diamond, David J. Saxby
Summary: The human semitendinosus muscle has separate proximal and distal neuromuscular compartments and the potential for independent operation and control. However, the morphology and function of these compartments have not been thoroughly examined in adult humans. This study used MRI to assess the morphological differences between the compartments in individuals who had undergone anterior cruciate ligament reconstruction. The results indicate that despite variations in length and volume, the compartments are not mechanically independent and show a correlation in morphological differences.
JOURNAL OF ANATOMY
(2023)
Article
Biophysics
Trevor N. Savage, David J. Saxby, David G. Lloyd, Claudio Pizzolato
Summary: The purpose of this study was to determine whether calibration of an NMS model resulted in consistent joint contact forces, regardless of EMD value or personalisation of Fo. Hip, knee, and ankle contact forces were predicted for 28 participants using EMG-informed NMS models. The results showed that calibrated models with EMD set between 35 and 70 ms produced similar magnitude and timing of peak joint contact forces.
JOURNAL OF BIOMECHANICS
(2023)
Article
Chemistry, Analytical
Giacomo Di Raimondo, Miel Willems, Bryce Adrian Killen, Sara Havashinezhadian, Katia Turcot, Benedicte Vanwanseele, Ilse Jonkers
Summary: This study proposes a full inertial-capture-based musculoskeletal modelling workflow for estimating joint contact forces. The results show that the proposed method can accurately estimate knee contact forces compared to motion capture, which is important for monitoring knee joint loading and assessing therapeutic effects in clinical practice.
Article
Rheumatology
Hylton B. B. Menz, Jamie J. J. Allan, Andrew K. K. Buldt, Karl B. B. Landorf, Flavia M. M. Cicuttini, Edward Roddy, Shannon E. E. Munteanu
Summary: This study aimed to determine whether neuropathic pain is a feature of first metatarsophalangeal (MTP) joint osteoarthritis (OA). By comparing pain questionnaire results and related factors, the study found that a significant proportion of individuals with first MTP joint OA experience neuropathic pain, which may partly explain the suboptimal responses to commonly used treatments. Screening for neuropathic pain may be useful in selecting targeted interventions and improving clinical outcomes.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Ziying Wu, Yilun Wang, Yuqing Zhang, Kim L. Bennell, Daniel K. White, Liusong Shen, Wei Ren, Jie Wei, Chao Zeng, Guanghua Lei
Summary: The COVID-19 pandemic has caused a decline in daily steps and physical activity levels. Studies show that over 7000 steps per day is the minimum standard for reducing the risk of all-cause mortality. The confinement period of COVID-19 has led to a significant decrease in daily steps among the general adult population.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Engineering, Biomedical
Ilse Jonkers, Erica Beaucage-Gauvreau, Bryce Adrian Killen, Dhruv Gupta, Lennart Scheys, Friedl De Groote
Summary: In this review, the evolution of musculoskeletal (MSK) modeling combined with dynamic movement simulation from a research tool to a promising in silico tool to assist medical decision-making is elaborated. Three different clinical conditions, degenerative joint disease, cerebral palsy, and adult spinal deformities, are discussed to demonstrate the clinical readiness of simulation frameworks and their integration into standard practice. The barriers to clinical integration and the challenges related to model assumptions, complexity, personalization, and implementation are also addressed.
JOURNAL OF APPLIED BIOMECHANICS
(2023)
Article
Multidisciplinary Sciences
Jason M. Konrath, Bryce A. Killen, David J. Saxby, Claudio Pizzolato, Ben A. Kennedy, Christopher J. Vertullo, Rod S. Barrett, David G. Lloyd
Summary: The study found that the morphology of donor muscles following ACL reconstruction can affect muscular support of the tibiofemoral joint during sidestep cutting. Computer simulation showed that the contribution of donor muscles decreased, while the contribution of the semimembranosus muscle increased. This suggests that donor muscle impairment could be a contributing factor to re-injury of the ACL following return to sport.
Article
Multidisciplinary Sciences
Ayda Karimi Dastgerdi, Amir Esrafilian, Christopher P. Carty, Azadeh Nasseri, Alireza Yahyaiee Bavil, Martina Barzan, Rami K. Korhonen, Ivan Astori, Wayne Hall, David John Saxby
Summary: This study developed subject-specific finite element (FE) models of the knee for typically developing pediatric individuals, using an atlas-based approach. The models accurately predicted pediatric knee kinematics and contact pressure distributions, demonstrating their potential for parametric analyses, clinical studies, and enhanced understanding of pediatric knee injury mechanisms.
SCIENTIFIC REPORTS
(2023)
Article
Rehabilitation
Kenth Louis Joseph, Hanne Dagfinrud, Kare Birger Hagen, Kristine Roren Norden, Camilla Fongen, Ole-Martin Wold, Rana S. Hinman, Rachel K. Nelligan, Kim L. Bennell, Anne Therese Tveter
Summary: This study aimed to describe adherence to a 12-week web-based aerobic exercise program in patients with hip or knee osteoarthritis, compare characteristics between adherent and non-adherent individuals, and identify barriers for exercising. Results showed that half of the patients adhered to the program, and the most frequently reported barrier was sickness.
JOURNAL OF REHABILITATION MEDICINE
(2023)
Article
Engineering, Biomedical
Zhengliang Xia, Daniel Devaprakash, Bradley M. Cornish, Rod S. Barrett, David G. Lloyd, Andrea H. Hams, Claudio Pizzolato
Summary: An artificial intelligence workflow was developed to predict strain in the Achilles tendon during running using motion capture data. Two AI workflows were compared, one directly predicting strain and the other predicting force and converting it to strain. The best predictions were achieved using position, velocity, height, and mass as input features.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Review
Sport Sciences
David G. Lloyd, David J. Saxby, Claudio Pizzolato, Matthew Worsey, Laura E. Diamond, Dinesh Palipana, Matthew Bourne, Ana Cardoso de Sousa, Malik Muhammad Naeem Mannan, Azadeh Nasseri, Nataliya Perevoshchikova, Jayishni Maharaj, Claire Crossley, Alastair Quinn, Kyle Mulholland, Tyler Collings, Zhengliang Xia, Bradley Cornish, Daniel Devaprakash, Gavin Lenton, Rodney S. Barrett
Summary: This paper outlines the importance of developing new training technologies to prevent and manage musculoskeletal injuries in military personnel. The use of personalized digital twins and wireless wearable devices for real-time biofeedback is discussed as a potential solution for ideal tissue mechanics targeting.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)