Oxidative DNA damage on the VEGF G‐quadruplex forming promoter is repaired via long‐patch BER

DNA Base Excision Repair Intermediates Influence Duplex–Quadruplex Equilibrium

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Promoters vs. telomeres: AP-endonuclease 1 interactions with abasic sites in G-quadruplex folds depend on topology

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APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response

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Oxidative Damage Induces a Vacancy G-Quadruplex That Binds Guanine Metabolites: Solution Structure of a cGMP Fill-in Vacancy G-Quadruplex in the Oxidized BLM Gene Promoter

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G-Quadruplex-Binding Proteins: Promising Targets for Drug Design

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Cysteine Oxidation to Sulfenic Acid in APE1 Aids G-Quadruplex Binding While Compromising DNA Repair

(2022) Shereen A. Howpay Manage et al.   ACS Chemical Biology

Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity

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Dynamic alternative DNA structures in biology and disease

(2022) Guliang Wang et al.   NATURE REVIEWS GENETICS

Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing

(2022) Coste Franck et al.   NUCLEIC ACIDS RESEARCH

Effect of DNA Glycosylases OGG1 and Neil1 on Oxidized G-Rich Motif in the KRAS Promoter

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DNA G-quadruplex structures: more than simple roadblocks to transcription?

(2021) Jenna Robinson et al.   NUCLEIC ACIDS RESEARCH

Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome

(2021) Sara Lago et al.   Nature Communications

The regulation and functions of DNA and RNA G-quadruplexes

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Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome

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Lesion Recognition and Cleavage of Damage-Containing Quadruplexes and Bulged Structures by DNA Glycosylases

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Whole genome experimental maps of DNA G-quadruplexes in multiple species

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Human NEIL3 Gene Expression Regulated by Epigenetic-Like Oxidative DNA Modification

(2019) Aaron M. Fleming et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing

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Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus

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Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence

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The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription

(2017) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair

(2017) Aaron M. Fleming et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-quadruplex structures mark human regulatory chromatin

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Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine

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An oxidative DNA “damage” and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression

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High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures

(2015) Jia Zhou et al.   NUCLEIC ACIDS RESEARCH

A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These “Spare Tires” Have an Evolved Function?

(2015) Aaron M. Fleming et al.   ACS Central Science

Human AP endonuclease inefficiently removes abasic sites within G4 structures compared to duplex DNA

(2014) Christopher Broxson et al.   NUCLEIC ACIDS RESEARCH

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes

(2013) Prashansa Agrawal et al.   NUCLEIC ACIDS RESEARCH

Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription

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NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Separation-of-Function Mutants Unravel the Dual-Reaction Mode of Human 8-Oxoguanine DNA Glycosylase

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Coexistence of Two Distinct G-Quadruplex Conformations in the hTERT Promoter

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Coordination between Polymerase β and FEN1 Can Modulate CAG Repeat Expansion

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Genome-wide analysis predicts DNA structural motifs as nucleosome exclusion signals

(2009) Kangkan Halder et al.   Molecular BioSystems

Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene

(2008) K. Guo et al.   NUCLEIC ACIDS RESEARCH

Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes

(2008) Johanna Eddy et al.   NUCLEIC ACIDS RESEARCH