Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models

Modulation of cytochrome P450 1A (CYP1A) enzymes by monomethylmonothioarsonic acid (MMMTAV) in vivo and in vitro

(2023) Mahmoud A. El-Ghiaty et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Arsenic trioxide (ATO) up-regulates cytochrome P450 1A (CYP1A) enzymes in murine hepatoma Hepa-1c1c7 cell line

(2023) Mahmoud A. El-Ghiaty et al.   Environmental Toxicology and Pharmacology

The Duality of Arsenic Metabolism: Impact on Human Health

(2022) Mahmoud A. El-Ghiaty et al.   Annual Review of Pharmacology and Toxicology

Down-regulation of hepatic cytochromes P450 1A1 and 1A2 by arsenic trioxide (ATO) in vivo and in vitro: A role of heme oxygenase 1

(2022) Mahmoud A. El-Ghiaty et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mercury and methylmercury differentially modulate hepatic cytochrome P450 1A1 and 1A2 in vivo and in vitro

(2022) Mohammed A. Alqahtani et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Balance between the toxicity and anticancer activitiy of arsenic trioxide in treatment of acute promyelocytic leukemia

(2020) Qian Qian Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hepatoprotective effects of zinc (II) via cytochrome P-450/reactive oxygen species and canonical apoptosis pathways after arsenite waterborne exposure in common carp

(2019) Hongjing Zhao et al.   CHEMOSPHERE

Dimethylarsinic acid modulates the aryl hydrocarbon receptor-regulated genes in C57BL/6 mice: in vivo study

(2017) Osama H. Elshenawy et al.   XENOBIOTICA

Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing

(2016) Birget Moe et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Thiolated arsenicals in arsenic metabolism: Occurrence, formation, and biological implications

(2016) Yuzhen Sun et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Modulation of aryl hydrocarbon receptor-regulated enzymes by trimethylarsine oxide in C57BL/6 mice: In vivo and in vitro studies

(2015) Osama H. Elshenawy et al.   TOXICOLOGY LETTERS

Modulation of aryl hydrocarbon receptor regulated genes by acute administration of trimethylarsine oxide in the lung, kidney and heart of C57BL/6 mice

(2015) Osama H. Elshenawy et al.   XENOBIOTICA

Acute arsenic treatment alters arachidonic acid and its associated metabolite levels in the brain of C57Bl/6 mice

(2014) Anwar Anwar-Mohamed et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Differential modulation of cytochrome P450 1a1 by arsenite in vivo and in vitro in C57BL/6 mice

(2013) Anwar Anwar-Mohamed et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential Modulation of Xenobiotic-Metabolizing Enzymes in Rats Following Single and Concurrent Exposure to Chlorpyrifos, Arsenic, and Ascorbic Acid

(2013) Dinesh Singh Rajpoot et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Acute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl/6 mice

(2013) Anwar Anwar-Mohamed et al.   XENOBIOTICA

Differential modulation of aryl hydrocarbon receptor regulated enzymes by arsenite in the kidney, lung, and heart of C57BL/6 mice

(2012) Anwar Anwar-Mohamed et al.   ARCHIVES OF TOXICOLOGY

Acute arsenic toxicity alters cytochrome P450 and soluble epoxide hydrolase and their associated arachidonic acid metabolism in C57Bl/6 mouse heart

(2012) Anwar Anwar-Mohamed et al.   XENOBIOTICA

Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma

(2011) Anouk van de Winkel et al.   BMC GASTROENTEROLOGY

Activity of Phase I and Phase II enzymes of the benzo[a]pyrene transformation pathway in zebrafish (Danio rerio) following waterborne exposure to arsenite

(2010) E. David Thompson et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities

(2010) C. J. Omiecinski et al.   TOXICOLOGICAL SCIENCES

Regulation of CYP1A1 by heavy metals and consequences for drug metabolism

(2009) Anwar Anwar-Mohamed et al.   Expert Opinion on Drug Metabolism & Toxicology

Analysis of humanCYP1A1andCYP1A2genes and their shared bidirectional promoter in eight world populations

(2009) Lucia F. Jorge-Nebert et al.   HUMAN MUTATION

Concurrent subacute exposure to arsenic through drinking water and malathion via diet in male rats: effects on hepatic drug-metabolizing enzymes

(2008) Suresh Babu Naraharisetti et al.   ARCHIVES OF TOXICOLOGY

The Nuclear Factor- B Pathway Regulates Cytochrome P450 3A4 Protein Stability

(2008) R. C. Zangar et al.   MOLECULAR PHARMACOLOGY

Involvement of Oxidative Stress and Activation of Aryl Hydrocarbon Receptor in Elevation of CYP1A1 Expression and Activity in Lung Cells and Tissues by Arsenic: An In Vitro and In Vivo Study

(2008) Jui-Pin Wu et al.   TOXICOLOGICAL SCIENCES

Arsenite and its metabolites, MMAIII and DMAIII, modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice

(2008) I.M. Medina-Díaz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY