Article
Environmental Sciences
Recep Liman, Muhammad Muddassir Ali, Ibrahim Hakki Cigerci, Erman Salih Istifli, Cengiz Sarikurkcu
Summary: This study investigated the cytotoxic and genotoxic effects of copper oxychloride on Allium cepa root cells, showing root growth inhibition, decreased mitotic index, increased chromosomal aberrations, and DNA damage. The two main polymorphs of copper oxychloride selectively bind to G and C nucleotides on DNA, potentially causing DNA damage through minor groove recognition and intercalation. Further molecular studies are needed to fully understand the cyto-genotoxic mechanism of action of copper oxychloride.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Farhana Masood, Ranjan Pandey, Harminder Pal Singh, Aditya Sen Gupta, Shalinder Kaur, Daizy Rani Batish, Ravinder Kumar Kohli
Summary: This study found that agricultural sites near industrial areas were contaminated with high concentrations of heavy metals and organic compounds, which poses genotoxic and mutagenic risks. Adequate measures should be taken to reduce the toxicity of industrial effluents discharged onto agricultural fields.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2021)
Article
Engineering, Environmental
Arpna Kumari, Vasiliy A. Chokheli, Vladimir S. Lysenko, Saglara S. Mandzhieva, Tatiana M. Minkina, Mahmoud Mazarji, Vishnu D. Rajput, Victoria A. Shuvaeva, Svetlana S. Sushkova, Anatoly Barakhov
Summary: This study compared the genotoxicity, cytotoxicity, and phytotoxicity of macro- and nano-forms of ZnO in plants. The results showed that the maximal effect was observed at a concentration of 30 times the maximal permissible concentration for both macro- and nano-forms of ZnO. The treatment with both forms of ZnO significantly affected the germination rate, root and shoot length of the barley plant in a dose-dependent manner. The mobility of nano-dispersed ZnO in the soil was higher than that of macro-dispersed ZnO, and it led to oxidative stress and increased toxicity implications in plants.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2022)
Article
Biology
Torsha Das, Soham Hazra, Sudip Sengupta, Pranab Hazra, Dipayan Chattopadhyay
Summary: The study found that aqueous saccharin solution can induce genotoxic effects on root growth inhibition, mitotic index, and chromosomal aberrations in Allium cepa, indicating the need for moderate and regulated dietary intake of saccharin.
Article
Environmental Sciences
Muhammad Muddassir Ali, Areej Fatima, Sadia Nawaz, Abdul Rehman, Maryam Javed, Asif Nadeem
Summary: Bisphenol S (BPS) is a substitute of bisphenol A and widely used in various products. This study evaluated the cytotoxic and genotoxic effects of BPS on onion root meristematic cells. The results showed that BPS inhibited root growth, reduced mitotic index, and caused chromosomal aberrations and DNA damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Recep Liman, Bermal Basbug, Muhammad Muddassir Ali, Yaser Acikbas, Ibrahim Hakki Cigerci
Summary: Tungsten oxide nanoparticles exhibit cytotoxic and genotoxic effects on Allium cepa cells, leading to a decrease in mitotic index, an increase in chromosomal aberrations, and significant DNA damage at different concentrations. Further investigation at the molecular level is warranted to evaluate the cytogenetic effects of WO(3)NPs.
JOURNAL OF APPLIED GENETICS
(2021)
Article
Environmental Sciences
Recep Liman, Muhammad Muddassir Ali, Erman Salih Istifli, Ibrahim Hakki Cigerci, Elena Bonciu
Summary: Pethoxamid is a chloroacetamide herbicide commonly used to kill weeds in crops. This study investigated the cytotoxic and genotoxic effects of pethoxamid on Allium cepa cells. The results showed that pethoxamid inhibited the root growth of onion and caused chromosomal aberrations and DNA damage. Molecular docking analysis revealed that pethoxamid binds selectively to GC-rich regions in DNA and has a high affinity for VLCFA synthases. Therefore, the genotoxicity and cytotoxicity of pethoxamid may be attributed to its multiple binding ability with DNA and VLCFA synthases.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Marwa F. F. Ali, Wafaa H. H. Mohamed
Summary: The present study investigated the genotoxic effects of pyridaben (PDB) in male Sprague Dawley rats. Four groups of rats were exposed to different doses of PDB for 4 weeks. Blood samples, femoral bone marrow, and liver samples were collected for various analyses. The results showed changes in hematological and biochemical parameters, increased gene expression of IL-6 and Casp-3, and histopathological findings in the liver with PDB exposure. However, there was no significant change in chromosomal aberrations.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
M. Alaguprathana, M. Poonkothai, Mysoon M. Al-Ansari, Latifah Al-Humaid, Woong Kim
Summary: This study assessed the cytogenotoxic effect of untreated and methyl orange treated on Allium cepa roots. It was found that roots exposed to treated dye solution had higher root growth, root length, and mitotic index, while roots exposed to untreated dye solution showed higher mitotic inhibition and chromosomal abnormalities. The research can be used as a biomarker to detect the genotoxic effects of textile dyes on biota.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Raphael B. de Souza, Cleiton Pereira de Souza, Jose Roberto Guimaraes
Summary: This study evaluated the phytotoxicity and genotoxicity of Eprinomectin, a veterinary drug widely used in the agricultural sector. The results showed that Eprinomectin affected root development and germination speed, as well as induced chromosomal aberrations and micronuclei. Therefore, the release of Eprinomectin into the environment should be minimized.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Eslem Amac, Recep Liman
Summary: This study evaluated the dose-dependent cytotoxicity and genotoxicity of clopyralid on Allium cepa roots, showing that clopyralid affects root growth and induces chromosome abnormalities at different concentrations. These results confirm the cytotoxic and genotoxic effects of clopyralid on non-target organisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Mandeep Kaur, Ming Xu, Lin Wang
Summary: This study investigated the effect of various sizes and concentrations of Polystyrene Micro-plastics (Ps-MPs) on root length and chromosomes of Allium cepa. Results indicated that larger Ps-MPs sizes had a significant impact on root length and cell division, inducing micro-nucleated cells and causing cyto-toxic and nuclear damage in the plant cells.
Article
Biochemistry & Molecular Biology
Maha A. Fahmy, Entesar E. Hassan, Ayman A. Farghaly, Zeinab M. Hassan
Summary: This study found that the genotoxicity of vinblastine (VB) not only affects somatic cells but also germ cells, leading to sperm defects and DNA damage. These findings have serious implications for future generations and the fertility of cancer survivors.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Food Science & Technology
Ghada Abd-Elmonsef Mahmoud, Hassan A. H. Soltan, Walid Mohamed Abdel-Aleem, Sayed A. M. Osman
Summary: Research has shown that red pigment can be used as a safe natural food pigment. The addition of sesame oil and corn starch in the medium significantly increased the production of red pigment. Tests on the stability of the pigment in common food components indicated that citric acid had a greater effect on stability compared to other acids.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Article
Chemistry, Multidisciplinary
Onisan Emilian, Sarac Ioan, Petrescu Irina, Pascalau Raul, Ciulca Adriana, Camen Dorin, Stroia Ciprian
Summary: Salt stress causes cytotoxicity, disrupting the vacuolization process and mitotic division, leading to inhibited plant growth. The experiment evaluated the effects of different NaCl concentrations on sunflower seeds, showing that salt stress increases vacuolization, decreases mitotic index, and increases chromosomal aberrations.
APPLIED SCIENCES-BASEL
(2023)
Article
Environmental Sciences
Patricia Lopez-Arellano, Keila Lopez-Arellano, Jaquelinne Luna, Diana Flores, Javier Jimenez-Salazar, Graciela Gavia, Mario Teteltitla, Juan Jose Rodriguez, Alejandro Dominguez, Eduardo Casas, Ivan Bahena, Miguel Betancourt, Cristina Gonzalez, Yvonne Ducolomb, Edmundo Bonilla
ENVIRONMENTAL TOXICOLOGY
(2019)
Article
Reproductive Biology
Lucila Alvarez-Barrera, Juan. J. Rodriguez-Mercado, Rodrigo A. Mateos-Nava, Yazmin Vazquez-Martinez, Mario A. Altamirano-Lozano
REPRODUCTIVE TOXICOLOGY
(2019)
Article
Toxicology
R. Martinez-Quezada, G. Gonzalez-Castaneda, I Bahena, A. Dominguez, P. Dominguez-Lopez, E. Casas, M. Betancourt, F. Casillas, J. J. Rodriguez, L. Alvarez, R. A. Mateos, M. A. Altamirano, E. Bonilla
Summary: Exposure to PFHxS inhibits oocyte maturation by decreasing m Delta Psi at the GVBD stage and inducing DNA damage in cumulus cells.
TOXICOLOGY IN VITRO
(2021)
Article
Environmental Sciences
Rodrigo Anibal Mateos-Nava, Juan Jose Rodriguez-Mercado, Lucila Alvarez-Barrera, Maria del Carmen Garcia-Rodriguez, Mario Agustin Altamirano-Lozano
Summary: In vitro assays have shown that vanadium compounds interact with biological molecules similar to protein kinases and phosphatases, leading to decreased cell proliferation in human lymphocytes. While DNA analysis did not show specific cell cycle phase delays, increased levels of the p53 protein may be responsible for this delay.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Teteltitla Mario, Ducolomb Yvonne, Souza Veronica, Dominguez Alejandro, Rodriguez-Mercado Juan, Flores Diana, Bonilla Edmundo, Casas Eduardo, Altamirano Mario, Lopez Alma, Bahena Ivan, Gutierrez Concepcion, Casillas Fahiel, Betancourt Miguel
Summary: Perfluorooctanoic acid has negative effects on both oocyte and cumulus cells, leading to increased generation of reactive oxygen species, protein oxidation, and DNA damage. This compromises the maturation and viability of porcine oocyte, potentially affecting fertility.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Veterinary Sciences
Alma Lopez, Miguel Betancourt, Yvonne Ducolomb, Juan Jose Rodriguez, Eduardo Casas, Edmundo Bonilla, Ivan Bahena, Socorro Retana-Marquez, Lizbeth Juarez-Rojas, Fahiel Casillas
Summary: This study showed that exposure of matured cumulus-oocyte complexes to cryoprotectants or vitrification resulted in decreased viability of oocytes and cumulus cells, and induced DNA damage in cumulus cells, subsequently affecting fertilization and embryo development rates.
PORCINE HEALTH MANAGEMENT
(2021)
Article
Environmental Sciences
Lucila Alvarez-Barrera, Juan Jose Rodriguez-Mercado, Rodrigo Anibal Mateos-Nava, Nydia Angelica Ocampo-Aguilera, Mario Agustin Altamirano-Lozano
Summary: This study found that administration of V2O4 to pregnant mice during the organogenesis period resulted in maternal and embryo-fetal toxicity, as well as external abnormalities in the offspring. The fetuses showed reduced ossification of cranial bones, corresponding to head injuries observed in the external assessment.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Maria de la Luz Buendia-Valverde, Fernando C. Gomez-Merino, Tarsicio Corona-Torres, Serafin Cruz-Izquierdo, Rodrigo A. Mateos-Nava, Libia Trejo-Tellez
Summary: This study investigated the effects of thallium on the leaf concentration of macronutrients and the stoichiometric relationships in chili peppers. The results showed that different varieties of chili pepper had different responses to thallium, with Jalapeno being the most affected and Poblano the least affected.
WATER AIR AND SOIL POLLUTION
(2022)
Article
Environmental Sciences
Alejandra Lopez Lanuza, Rodrigo Anibal Mateos Nava, Lucila Alvarez Barrera, Juan Jose Rodriguez Mercado
Summary: Gallium (Ga), indium (In) and thallium (Tl) are metals that belong to group 13 (IIIA) of the periodic table. Despite their various industrial applications, they do not have any recognized biological functions. This review summarizes the available information on contamination, human exposure, toxicokinetics, and genotoxicity associated with Ga, In, and Tl in their +3 oxidation state in mammals. These metals can induce adverse effects on human health by affecting oxidative stress, molecular functions, and causing damage to biomolecules like DNA.
REVISTA INTERNACIONAL DE CONTAMINACION AMBIENTAL
(2023)
Article
Multidisciplinary Sciences
Maria de los Angeles Reyes-Rodriguez, Luis Felipe Santos-Cruz, Carlos Garcia-Castro, Angel Duran-Diaz, Laura Castaneda-Partida, Irma Elena Duenas-Garcia, Maria Eugenia Heres-Pulido, Juan Jose Rodriguez-Mercado
Summary: Thallium is a heavy and toxic metal derived from human activities, posing environmental and health risks. Research shows that thallium compounds have genotoxic effects on Drosophila, with high concentrations of thallium sulfate causing cell mutation and recombination. Further evaluation is needed to assess the genetic toxicity risks associated with bioaccumulation of thallium and its compounds.
