Article
Immunology
Jingxuan Zhou, Nanhai Zhang, Adil Aldhahrani, Mohamed Mohamed Soliman, Liebing Zhang, Feng Zhou
Summary: Puerarin improves high-fat and high-fructose diet-induced nonalcoholic fatty liver disease (NAFLD) by modulating liver lipid accumulation, liver function, oxidative stress, and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jing Zhang, Quansheng Feng
Summary: Astragalus polysaccharides (APS), a chemical molecule derived from Astragalus membranaceus, have shown potential therapeutic effects on nonalcoholic fatty liver disease (NAFLD). APS may help slow the progression of NAFLD through multiple molecular pathways. However, further research and clinical evidence are still needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Agnieszka Karkucinska-Wieckowska, Ines C. M. Simoes, Piotr Kalinowski, Magdalena Lebiedzinska-Arciszewska, Krzysztof Zieniewicz, Piotr Milkiewicz, Magdalena Gorska-Ponikowska, Paolo Pinton, Afshan N. Malik, Marcin Krawczyk, Paulo J. Oliveira, Mariusz R. Wieckowski
Summary: According to the 'multiple-hit' hypothesis, both nitro-oxidative stress and mitochondrial abnormalities are key factors in the progression of NAFLD. It is difficult to determine whether mitochondrial dysfunction or oxidative stress are primary events or consequences of NAFLD development, but they play significant roles in the transition from simple steatosis to more severe NAFLD stages.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Endocrinology & Metabolism
Alexandra Tsankof, Georgios Neokosmidis, Evgenia Koureta, Stavroula Veneti, Evangelos Cholongitas, Konstantinos Tziomalos
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that affects a significant portion of the global population. Obesity is a major risk factor for NAFLD, but lifestyle measures rarely lead to substantial and sustained weight loss. Antiobesity agents are considered in the management of NAFLD, but limited data exist on their safety and effectiveness. Glucagon-like peptide-1 receptor agonists, liraglutide and semaglutide, may be a first-line option for obese patients with NAFLD and type 2 diabetes mellitus (T2DM), as they induce significant weight loss and have been extensively studied in T2DM patients. However, more research is needed to evaluate their effects on liver-related and cardiovascular outcomes in NAFLD patients, especially those without T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lu Xu, Jingyang Zhou, Jinhui Che, Haihong Wang, Weizhong Yang, Wuyuan Zhou, Hongying Zhao
Summary: Mitochondrial damage exacerbates NAFLD through triggering AIM2 inflammasome activation and hepatocyte pyroptosis. This study provides novel insights into the underlying mechanisms of mitochondrial DNA synthesis in NAFLD and also suggests potential therapeutic targets for the treatment of NAFLD.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mara Caputo, Yeshwant Kurhe, Sima Kumari, Emmelie Cansby, Manoj Amrutkar, Eli Scandalis, Sheri L. Booten, Marcus Stahlman, Jan Boren, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Summary: This study identifies MST3 as a critical regulator of ectopic fat accumulation in human hepatocytes and shows that targeting MST3 signaling with ASOs can effectively mitigate NAFLD progression in obese mice. MST3 ASOs suppress lipogenic gene expression, reduce lipotoxicity-mediated oxidative and endoplasmic reticulum stress, and correlate with NAFLD severity in human liver biopsies. These findings suggest that MST3 inhibitors may offer a new strategy for treating NAFLD patients.
Article
Medicine, Research & Experimental
Yuanqiang Zhang, Jing Wen, Dongqing Liu, Zhen Qiu, Qianqian Zhu, Ruiyan Li, Yubin Zhang
Summary: The results of the study suggest that DMTHB can effectively alleviate NAFLD by reducing inflammation, inhibiting the NLRP3 inflammasome, alleviating oxidative and ER stress, and improving liver fibrosis. Therefore, DMTHB may have therapeutic benefits for NAFLD treatment in the clinic.
Article
Medicine, General & Internal
Guang-Hui Deng, Chao-Feng Wu, Yun-Jia Li, Hao Shi, Wei-Chao Zhong, Mu-Keng Hong, Jun-Jie Li, Jia-Min Zhao, Chang Liu, Meng-Chen Qin, Zhi-Yun Zeng, Wei-Min Zhang, Ken Kin Lam Yung, Zhi-Ping Lv, Lei Gao
Summary: This study confirms that Cav-1 is a key protein that regulates iron and lipid metabolism homeostasis. It plays a crucial role in predicting and protecting against the development of NAFLD.
MILITARY MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tingyi Du, Qin Fang, Zhihao Zhang, Chuanmeng Zhu, Renfan Xu, Guangzhi Chen, Yan Wang
Summary: This study shows that Lentinan (LNT) can ameliorate hepatic steatosis, decrease oxidative stress and apoptosis by activating the PPAR alpha pathway, providing a potential drug target for NAFLD.
Article
Fisheries
Cuiyun Zou, Yuke Fang, Nuoyi Lin, Huifan Liu
Summary: This study investigated the anti-NAFLD effect of YZW-A in hybrid grouper fed a high-fat diet, showing improved growth performance and reduced lipid content in various tissues. YZW-A also modulated key factors of lipid metabolism and activated the AMPK pathway, suggesting its therapeutic potential for NAFLD treatment in fish.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Yuhang Li, Juxiong Liu, Bojian Ye, Yueyao Cui, Ruiqi Geng, Shu Liu, Yufei Zhang, Wenjin Guo, Shoupeng Fu
Summary: Astaxanthin (AT) can improve lipid metabolism disorders and reduce oxidative stress in high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) mice, as well as influence the structure of gut flora.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sarawoot Bunbupha, Poungrat Pakdeechote, Putcharawipa Maneesai, Patoomporn Prasarttong
Summary: The study demonstrates that nobiletin has a significant therapeutic effect on HFD-induced NAFLD and metabolic dysfunction in rats, possibly through modulation of AdipoR1 and gp91(phox). High dose of nobiletin shows better efficacy compared to low dose.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
ChenLu Zhao, JunHao Shi, DongFang Shang, Min Guo, Cheng Zhou, WenXia Zhao
Summary: Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease that seriously endangers global public health. The incidence of NAFLD in postmenopausal women has significantly increased, and estrogen deficiency is the main reason for this situation. Traditional estrogen replacement therapy has risks, and phytoestrogens have emerged as a promising method for preventing and treating postmenopausal NAFLD. However, the mechanism of phytoestrogens in NAFLD is still unclear.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Hsuan-Chih Huang, Pei-Ni Lee, Wen-Chih Huang, Hsin-Yi Yang
Summary: This study found that the dietary intake of dehulled adlay may slow down the progression of NAFLD by improving hepatic steatosis, inflammation, oxidative stress, and gut dysbiosis.
Article
Gastroenterology & Hepatology
Alberto Hernandez-Bustabad, Dalia Morales-Arraez, Francisco Javier Gonzalez-Paredes, Beatriz Abrante, Felicitas Diaz-Flores, Pedro Abreu-Gonzalez, Raquel de la Barreda, Enrique Quintero, Manuel Hernandez-Guerra
Summary: Chronic intermittent hypoxia exacerbates impaired hepatic endothelial dysfunction in rats with nonalcoholic fatty liver disease. As obstructive sleep apnea syndrome is associated with systemic endothelial dysfunction in cardiovascular disorders, and chronic intermittent hypoxia is an independent and reversible risk factor for hypertension and coronary artery disease, this study suggests that it may be relevant in the pathophysiology of nonalcoholic fatty liver disease.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Clinical Neurology
Emrah Kantarcioglu, Gokmen Kahilogullari, Murat Zaimoglu, Esin Ozlem Atmis, Elif Peker, Zeynep Yigman, Deniz Billur, Sevim Aydin, Ilhan Memet Erden, Agahan Unlu
CHILDS NERVOUS SYSTEM
(2018)
Article
Cell Biology
Zeynep Yigman, Elif Derya Ozdemir, Nilufer N. Turan, A. Tulga Ulus, Alp Can
Article
Chemistry, Medicinal
Cagri Ozdemir, Mustafa Arslan, Aysegul Kucuk, Zeynep Yigman, Ali Dogan Dursun
Summary: Oxidative stress is important in the development of Alzheimer's disease. Boric acid (BA) has neuroprotective effects through its ability to reduce lipid peroxidation and support antioxidant defense. This study aimed to evaluate the therapeutic potential of BA treatment in rats with Alzheimer's disease.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Reproductive Biology
Seyma Osmanlioglu, Mustafa Arslan, Rumeysa Osmanlioglu Dag, Zeynep Yigman, Mueserref Seyma Ceyhan, Fatma Er, Mustafa Kavutcu
Summary: This study investigates the effect of artemisinin (ARS) in treating adnexal torsion, a common gynecological surgical emergency. The results show that ARS pretreatment can protect the ovaries from ischemia-reperfusion injury, and the dose of 50 mg/kg is more effective than 10 mg/kg.
REPRODUCTIVE TOXICOLOGY
(2023)
Meeting Abstract
Physiology
Ayse Meltem Sevgili, Pelin Sahin, Sevtap Kilinc, Zeynep Yigman, Hamit Ozyurek
Meeting Abstract
Physiology
Sevtap Kilinc, Pelin Sahin, Zeynep Yigman, Ayse Meltem Sevgili
Review
Medicine, General & Internal
Sevtap Kilinc, Ayse Meltem Sevgili
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, with a potential progression to liver cirrhosis. Oxidative stress plays a crucial role in its pathogenesis, and antioxidant agents may have a positive effect. Although there is currently no approved pharmacological treatment, vitamin E is recommended for its antioxidant activity. Topiramate, known for its weight loss and antioxidant effects, may be an option for NAFLD treatment.
GAZI MEDICAL JOURNAL
(2022)
Meeting Abstract
Physiology
Ayse Meltem Sevgili, Selda Ertac-Serdar, Selcuk Atalay, Gulriz Erisgen
Meeting Abstract
Physiology
Ayse Meltem Sevgili, Kutluhan Ertekin