Synthesis and characterization of cell-microenvironment-sensitive leakage-free gold-shell nanoparticles with the template of interlayer-crosslinked micelles

Novel gold-shell nanoparticles (pH-GSNPs) are designed for the first time, which exhibit drug leakage-free behavior in a physiological environment, while achieving rapid drug release and remarkable aggregation for the nanogold interlayer of pH-GSNPs to shift their absorption to far-red and NIR as a photothermal agent in the intracellular microenvironment.