Article
Gastroenterology & Hepatology
Sergei Vosko, Neal Shahidi, Mayenaaz Sidhu, W. Arnout van Hattem, Iddo Bar-Yishay, Scott Schoeman, David J. Tate, Luke F. Hourigan, Rajvinder Singh, Alan Moss, Karen Byth, Eric Y. T. Lee, Nicholas G. Burgess, Michael J. Bourke
Summary: This study found significant differences in optical evaluation performance between flat and nodular large nonpedunculated colorectal polyps. Flat lesions can be presumed benign and managed accordingly, while nodular lesions are more likely to be missed for submucosal invasive cancer.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Claire Haumesser, Melissa Zarandi-Nowroozi, Mahsa Taghiakbari, Roupen Djinbachian, Maria Abou Khalil, Sacha Sidani, Jeremy Liu Chen Kiow, Benoit Panzini, Ioana Popescu Crainic, Daniel von Renteln
Summary: The virtual scale endoscope (VSE) allows real-time size measurements of colorectal polyps by projecting a virtual scale onto them. In this study, the relative accuracy of VSE compared to visual assessment (VA) was evaluated for measuring simulated polyps of different sizes and morphologies. The results showed that VSE had significantly higher relative accuracies than VA for all size groups larger than 5mm, and for all morphology groups.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Mayenaaz Sidhu, Neal Shahidi, Sunil Gupta, Lobke Desomer, Sergei Vosko, W. Arnout van Hattem, Luke F. Hourigan, Eric Y. T. Lee, Alan Moss, Spiro Raftopoulos, Steven J. Heitman, Stephen J. Williams, Simon Zanati, David J. Tate, Nicholas Burgess, Michael J. Bourke
Summary: Thermal ablation of the defect margin after endoscopic mucosal resection (EMR-T) has been shown to significantly reduce residual or recurrent adenoma (RRA) at first surveillance colonoscopy. In an international multi-center prospective trial, EMR-T was found to be a simple, inexpensive, and highly effective auxiliary technique for managing large nonpedunculated colorectal polyps.
Article
Gastroenterology & Hepatology
Ryo Shimoda, Takashi Akutagawa, Michito Tomonaga, Tatsuro Murano, Kensuke Shinmura, Masato Yoshioka, Yuichi Teramura, Fumiaki Kiyomi, Hiroaki Ikematsu
Summary: This study compared the accuracy of polyp size estimation between the virtual scale endoscope (VSE) and visual estimation. The results showed that VSE had superior accuracy, although it required more time for estimation.
DIGESTIVE ENDOSCOPY
(2022)
Article
Health Care Sciences & Services
Ka Luen Thomas Lui, Sze Hang Kevin Liu, Kathy Leung, Joseph T. Wu, Ann G. Zauber, Wai Keung Leung
Summary: The widespread adoption of computer-aided detection (CADe) in detecting colorectal polyps would result in shorter surveillance intervals for patients, particularly according to the US Multi-Society Task Force on Colorectal Cancer (USMSTF) guideline. Based on simulation, CADe application would lead to approximately 19.1% and 1.9% of patients requiring shorter surveillance intervals, as recommended by the USMSTF and European Society of Gastrointestinal Endoscopy (ESGE) guidelines, respectively. Specifically, all or 2.7% of patients initially scheduled for 3-5 years of surveillance would have their intervals shortened to 3 years, according to the USMSTF guideline.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Surgery
Jennifer Liang, James M. Church
Summary: There is a linear relationship between endoscopic and pathologic size of colorectal polyps, but there is a systematic error.
ANZ JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Soham Rege, Elliot Coburn, Douglas J. Robertson, Audrey H. Calderwood
Summary: Only 35% of adults aged 75 and older are recommended to stop surveillance colonoscopy. The presence of polyps was strongly associated with fewer recommendations to stop. The variation in endoscopist recommendations highlights an opportunity to better standardize recommendations following colonoscopy in older adults.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Oncology
Oliver Cronin, Michael J. Bourke
Summary: Endoscopic resection (ER) of large non-pedunculated colorectal polyps Gastric Emptying (GE) 20 mm (LNPCPs) is safe, effective and preferred over surgery. Predicting the histopathology of LNPCPs based on various factors is crucial for choosing the appropriate resection technique. Adjuvant techniques, such as thermal ablation, reduce recurrence rates, and endoscopic surveillance is important for detecting and managing recurrence.
Review
Gastroenterology & Hepatology
Silvia Pecere, Giulio Antonelli, Mario Dinis-Ribeiro, Yuichi Mori, Cesare Hassan, Lorenzo Fuccio, Raf Bisschops, Guido Costamagna, Eun Hyo Ji, Dongheon Lee, Masashi Misawa, Helmut Messmann, Federico Iacopini, Lucio Petruzziello, Alessandro Repici, Yutaka Saito, Prateek Sharma, Masayoshi Yamada, Cristiano Spada, Leonardo Frazzoni
Summary: The widespread adoption of optical diagnosis of colorectal neoplasia is hindered by inadequate performance and lack of standardized training and competence evaluation for endoscopists. This study aimed to evaluate the diagnostic accuracy of endoscopists in optical diagnosis of colorectal neoplasia using artificial intelligence (AI) validation studies. The results showed suboptimal accuracy in human diagnosis, and educational interventions could benefit from AI validation settings for competence assessment.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Cesare Hassan, Giuseppina Balsamo, Roberto Lorenzetti, Angelo Zullo, Giulio Antonelli
Summary: This study demonstrates that artificial intelligence (AI) exceeds the required benchmarks for the optical diagnosis of colorectal polyps. AI could help implement cost-saving strategies in colonoscopy by reducing the burden of polypectomy and/or pathology.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Iddo Bar-Yishay, Neal Shahidi, Sunil Gupta, Sergei Vosko, W. Arnout van Hattem, Scott Schoeman, Mayenaaz Sidhu, David J. Tate, Luke F. Hourigan, Rajvinder Singh, Alan Moss, Spiro C. Raftopoulos, Gregor Brown, Simon Zanati, Steven J. Heitman, Eric Y. T. Lee, Nicholas Burgess, Stephen J. Williams, Karen Byth, Michael J. Bourke
Summary: The study evaluated the outcomes of intra-procedural deep mural injury (DMI) in large non-pedunculated colorectal polyps (LNPCPs) undergoing endoscopic mucosal resection (EMR). It found that significant DMI can be managed endoscopically with high success rates and does not impact technical success or recurrence.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Rupinder Mann, Mahesh Gajendran, Chandraprakash Umapathy, Abhilash Perisetti, Hemant Goyal, Shreyas Saligram, Juan Echavarria
Summary: Most colorectal cancers originate from adenomatous polyps and sessile serrated lesions. Screening colonoscopy combined with therapeutic polypectomy is an effective approach to decrease colorectal cancer incidence and mortality by detecting and removing these polyps at an early stage. Although the majority of polyps can be detected and removed by routine colonoscopy, complex polyps require advanced endoscopic techniques for management.
FRONTIERS IN MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Carola Rotermund, Roupen Djinbachian, Mahsa Taghiakbari, Markus D. Enderle, Axel Eickhoff, Daniel von Renteln
Summary: This study conducted a systematic review and meta-analysis to analyze the local recurrence rates (LRRs) of large colonic polyps. The results showed that endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) with routine margin ablation significantly reduced LRR compared to standard EMR. These techniques should be considered as the standard for endoscopic removal of large colorectal polyps.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Lina Cadili, Michael Horkoff, Scott Ainslie, Brian Chai, Jeffrey S. Demetrick, Karl Langer, Kevin Wiseman, Hamish Hwang
Summary: The introduction of a formalized protocol for the management of complex polyps has led to improved documentation, multidisciplinary discussion, and optimized management, particularly for polyps over 3 cm.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Health Care Sciences & Services
Scarlet Nazarian, Ben Glover, Hutan Ashrafian, Ara Darzi, Julian Teare
Summary: Artificial intelligence technologies show great potential in improving the detection and characterization of colorectal polyps, ultimately reducing the incidence of colorectal cancer. The current generation of AI-based systems demonstrate impressive accuracy in detecting and characterizing colorectal polyps.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Motomitsu Fukuhara, Yuji Urabe, Shiro Oka, Jyunichi Mizuno, Hidenori Tanaka, Ken Yamashita, Yuichi Hiyama, Hidehiko Takigawa, Takahiro Kotachi, Ryo Yuge, Koji Arihiro, Shinji Tanaka
Summary: Complete resection of metachronous esophageal squamous cell carcinoma close to post-ESD scars is challenging due to lower resection rate, longer procedure time, higher proportion of severe fibrosis, and increased intraoperative bleeding. Lesions located on the oral side of the post-ESD scar significantly affect the incidence of incomplete resection.
Article
Gastroenterology & Hepatology
Hirosato Tamari, Shiro Oka, Takahiro Kotachi, Hajime Teshima, Junichi Mizuno, Motomitsu Fukuhara, Hidenori Tanaka, Akiyoshi Tsuboi, Ken Yamashita, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Koji Arihiro, Shinji Tanaka
Summary: The aim of this study was to evaluate the efficacy and safety of gastric endoscopic submucosal dissection (ESD) using the SB Knife GX. A retrospective study was conducted on 716 patients who underwent gastric ESD, comparing the outcomes between the SB-GX group (45 patients) and the IT-2 group (671 patients). The SB Knife GX showed advantages in intraoperative bleeding control, although the procedure time was slightly longer.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Gastroenterology & Hepatology
Naoko Nagasaki, Hidehiko Takigawa, Masanori Ito, Tomoyuki Boda, Takahiro Kotachi, Ryohei Hayashi, Ryo Yuge, Yuji Urabe, Shiro Oka, Shinji Tanaka
Summary: This study aimed to identify the normal serum gastrin concentrations in normal stomach cases and investigate the usefulness of serum gastrin concentrations in diagnosing gastritis. The results showed that a gastrin cut-off value of 126 pg/mL has a good positive predictive value (97.0%) for detecting gastritis.
BMC GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Takeshi Takasago, Ryohei Hayashi, Yoshitaka Ueno, Misa Ariyoshi, Kana Onishi, Ken Yamashita, Yuichi Hiyama, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Shiro Oka, Yasuhiko Kitadai, Shinji Tanaka
Summary: Anti-TNF alpha mAb acts as an inhibitor of tumor progression in the tumor microenvironment of a colorectal cancer orthotopic transplant mouse model by regulating immune response, apoptosis, angiogenesis, and tumor immunity.
Article
Gastroenterology & Hepatology
Motomitsu Fukuhara, Yuji Urabe, Shiro Oka, Kazuki Ishibashi, Hirona Konishi, Junichi Mizuno, Hidenori Tanaka, Akiyoshi Tsuboi, Ken Yamashita, Yuichi Hiyama, Hidehiko Takigawa, Takahiro Kotachi, Ryo Yuge, Ryohei Hayashi, Ikuno Nishibuchi, Yuji Murakami, Yasushi Nagata, Shinji Tanaka
Summary: This study aimed to identify endoscopic findings associated with the risk of non-radical cure after definitive chemoradiotherapy for cT1bN0M0 esophageal squamous cell carcinoma. The study found that larger tumor size, presence of B3 vessels, and type 0-I lesions had a higher risk of non-radical cure after treatment.
Article
Oncology
Hidehiko Takigawa, Ryo Yuge, Ryo Miyamoto, Rina Otani, Hiroki Kadota, Yuichi Hiyama, Ryohei Hayashi, Yuji Urabe, Kazuhiro Sentani, Naohide Oue, Yasuhiko Kitadai, Shiro Oka, Shinji Tanaka
Summary: This study aimed to explore predictive markers for the efficacy of eradication therapy in gastric mucosa-associated lymphoid tissue (MALT) lymphoma patients negative for both API2-MALT1 and Helicobacter pylori (Hp). Gene expression analysis identified OLFM4 and NANOG as potential predictive markers for eradication therapy efficacy in these patients.
Article
Oncology
Rina Otani, Hidehiko Takigawa, Ryo Yuge, Daisuke Shimizu, Misa Ariyoshi, Ryo Miyamoto, Hiroki Kadota, Yuichi Hiyama, Ryohei Hayashi, Yuji Urabe, Akira Ishikawa, Naohide Oue, Yasuhiko Kitadai, Shiro Oka, Shinji Tanaka
Summary: In this study, the significance of LAT1 expression in cancer progression was clarified through database analysis and clinical specimens. The efficacy of JPH203 in vitro and in vivo was also demonstrated. LAT1 expression plays an important role in colorectal cancer, and JPH203 may inhibit cancer progression and tumor stromal activity.
Article
Gastroenterology & Hepatology
Issei Hirata, Akiyoshi Tsuboi, Yuka Matsubara, Akihiko Sumioka, Takeshi Takasago, Hidenori Tanaka, Ken Yamashita, Hidehiko Takigawa, Takahiro Kotachi, Ryo Yuge, Yuji Urabe, Shiro Oka
Summary: This study investigated the long-term outcomes of 461 patients with OGIB after CE, revealing that rebleeding from the small bowel was rare in the P0 group, and a history of endoscopic hemostasis and P1 CE findings were predictive of small-bowel rebleeding.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Hirosato Tamari, Yasuhiko Kitadai, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Fumio Shimamoto, Shiro Oka
Summary: In colorectal cancer, tumor-infiltrating T cells are associated with lymph node metastasis and prognosis. This study investigated the relationship between T cells and lymph node metastasis in early-stage CRC and found that a higher number of Foxp3+ T cells and higher Foxp3/CD4 and Foxp3/CD8 ratios at the invasive front of the tumor were associated with lymph node metastasis. Tumor invasion was also positively correlated with the number of T cells in CRC.
Meeting Abstract
Gastroenterology & Hepatology
Takeshi Takasago, Ryohei Hayashi, Yoshitaka Ueno, Misa Ariyoshi, Ken Yamashita, Yuichi Hiyama, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Yasuhiko Kitadai, Shiro Oka, Shinji Tanaka
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Takeshi Takasago, Ryohei Hayashi, Yoshitaka Ueno, Misa Ariyoshi, Ken Yamashita, Yuichi Hiyama, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Yasuhiko Kitadai, Shiro Oka, Shinji Tanaka
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Issei Hirata, Akiyoshi Tsuboi, Shiro Oka, Yuka Matsubara, Akihiko Sumioka, Hidenori Tanaka, Ken Yamashita, Hidehiko Takigawa, Yuichi Hiyama, Takahiro Kotachi, Ryo Yuge, Ryohei Hayashi, Yuji Urabe, Shinji Tanaka
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Oncology
Hiroki Kadota, Ryo Yuge, Misa Ariyoshi, Daisuke Shimizu, Ryo Miyamoto, Rina Ohtani, Hidehiko Takigawa, Shiro Oka, Yasuhiko Kitadai, Shinji Tanaka
Meeting Abstract
Oncology
Ryo Miyamoto, Hidehiko Takigawa, Rina Ohtani, Hiroki Kadota, Ryo Yuge, Yasuhiko Kitadai, Shinji Tanaka
