Review
Medicine, General & Internal
Dennisdhilak Lourdusamy, Vamsee Krishna Mupparaju, Navila Fahmida Sharif, Uzoma N. Ibebuogu
Summary: Heyde's syndrome is a rare systemic disease in older adults, characterized by aortic stenosis, angiodysplasia with bleeding, and acquired von Willebrand syndrome. There are currently no established guidelines for managing the condition, but further studies may change the approach to treatment. Increasing awareness and suspicion of the syndrome can improve diagnostic potential.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Review
Cardiac & Cardiovascular Systems
Ramy Abdelmaseih, Ravi Thakker, Randa Abdelmasih, Arroj Ali, Mustajab Hasan
Summary: Heyde's syndrome is a multisystem disorder characterized by the association between calcified aortic stenosis, gastrointestinal tract bleeding from arteriovenous malformations, and acquired von Willebrand syndrome. The prevalence and management of Heyde's syndrome remain controversial. Our review provides a unique case to highlight the diagnosis and management of Heyde's syndrome, as well as briefly describing the prevalence, etiology, diagnosis, and management of calcific aortic valve disease in general.
CURRENT PROBLEMS IN CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Mario Gutierrez, Chandrasekhar Kesavan, Anjali Das, Christian S. Jackson, Richard M. Strong
Summary: This study retrospectively investigated 312 patients with gastrointestinal angiodysplasia. The results showed that iron treatment alone is more effective than somatostatin analogs in recovering from gastrointestinal angiodysplasia and can save a significant amount of medical costs. It is suggested to perform device-assisted enteroscopy on patients with ongoing bleeding, perform lesion ablation using a coagulation method, and provide iron supplementation.
Article
Medicine, General & Internal
Hira Cheema, Russell Roark, Seemeen Hassan, Kalyan Chakrala, Benjamin Tharian, Jiannis Anastasiou
Summary: Heyde syndrome is a rare disease characterized by aortic stenosis, anemia due to angiodysplasia-related bleeding, and von Willebrand syndrome type 2A. Treatment modalities include symptomatic management, blood transfusions, aortic valve replacement, and medications like octreotide.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Adham E. Obeidat, Jean Kim
Summary: Heyde's syndrome is defined as the coexistence of AS and GI bleeding from IA, requiring a high clinical suspicion for diagnosis. This case study discusses a 60-year-old male patient with severe AS presenting with recurrent GI bleeding and multiple intestinal angioectasias on endoscopy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Oncology
Shria Kumar, Natalie Farha, Carol A. Burke, Bryson W. Katona
Summary: This article reviews the risks of upper gastrointestinal cancers in Lynch syndrome, the varying recommendations for surveillance, the outcomes of surveillance, and the controversies in the field. Based on collective experience, a framework for incorporating upper gastrointestinal cancer surveillance into a risk management program for Lynch syndrome is provided.
Article
Gastroenterology & Hepatology
Joao A. Cunha Neves, Joana Roseira, Patricia Queiros, Helena Tavares Sousa, Gianluca Pellino, Miguel F. Cunha
Summary: In this interventional study, sustainability measures were applied to achieve reduction of regulated medical waste and daily recycling in endoscopy practice, without compromising productivity.
Review
Medicine, General & Internal
Nelson Musilanga, Hongli Zhou, Hongyu Cai
Summary: The occurrence of bleeding gastrointestinal angioectasia in elderly patients with degenerative calcific aortic stenosis, known as Heyde's syndrome, is a challenging clinical scenario. Heyde's syndrome is mainly caused by the loss of high-molecular-weight von Willebrand factor (HMW vWF) multimers due to their fragmentation passing through the stenosed aortic valve, resulting in acquired von Willebrand syndrome type IIA. Aortic valve replacement has been shown to be a more effective management approach for cessation of recurrent episodes of gastrointestinal bleeding, and a high index of suspicion is needed when dealing with elderly patients with established aortic stenosis presenting with iron deficiency anemia or unclear gastrointestinal bleeding. Collaboration between different specialties is essential for appropriate management.
EGYPTIAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Rui Li, Shuliang Ji, Jiaxi Shi, Lijin Qing, Wei Wu, Jiechun Zhang
Summary: Clinicians should be aware of the atypical presentation of Heyde's syndrome and the limited accuracy of diagnostic examinations. In this case, a patient's gastrointestinal bleeding was not completely cured through surgery, but was eventually stopped after transcatheter aortic valve implantation. Therefore, aortic valve replacement may be an effective treatment for Heyde's syndrome.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Article
Multidisciplinary Sciences
Hsuan-Jen Hung, Chen-Shuan Chung, Chi-Ming Tai, Chen-Wang Chang, Chao-Ming Tseng, Go-Shine Huang, Meng-Chiung Lin, Tien-Yu Huang
Summary: Valvular heart disease may increase the risk of rebleeding after deep enteroscopy in uremic patients with obscure gastrointestinal bleeding (OGIB). Uremic patients with angiodysplasia-related bleeding are more likely to experience rebleeding compared to those with alternative causes.
Article
Gastroenterology & Hepatology
Ye Chu, Fang Huang, Min Gao, Duo-Wu Zou, Jie Zhong, Wei Wu, Qi Wang, Xiao-Nan Shen, Ting-Ting Gong, Yuan-Yi Li, Li-Fu Wang
Summary: In this study, a segmentation network based on deep learning was proposed for segmenting and recognizing angiodysplasia lesions, which provides an efficient and feasible method for diagnosing such lesions. The test results showed satisfactory results in terms of pixel accuracy, mean intersection over union, negative predictive value, and positive predictive value.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Caterina Chiara De Carlini, Edoardo Cantu, Nicoletta Erba, Stefano Maggiolini
Summary: This article reports two cases of Heyde's syndrome treated successfully for anemia by percutaneous aortic valve replacement. Iron deficiency anemia and aortic stenosis are commonly associated in the elderly, and the correct diagnosis of Heyde's syndrome is crucial for deciding whether to treat valve stenosis.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Veterinary Sciences
Alice Defarges, Jenny Stiller, Jeffrey A. Solomon
Summary: This study describes the signalment, clinical features, and diagnostic characteristics of dogs with gastrointestinal angiodysplasia (AGD) diagnosed by video capsule endoscopy (VCE). The results indicate that AGD is rare in dogs; however, it should be considered in dogs with suspected gastrointestinal bleeding after negative conventional endoscopy or surgical exploration. VCE appears to be a sensitive test for identifying AGD within the gastrointestinal tract.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
M. Manjappa, D. Kumar, N. S. Devananda
Summary: Heyde's syndrome is a condition where elderly patients with severe calcific aortic stenosis (AS) experience angio-dysplastic gastrointestinal bleeding, resulting in anemia. Although less familiar, its incidence is increasing alongside the rising geriatric population. It has also been associated with other cardiovascular conditions.
INDIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Chemistry, Multidisciplinary
Sang-Hyun Kim, Hyuk-Soon Choi, Bora Keum, Hoon-Jai Chun
Summary: Recent advancements in endoscopic technology have revolutionized the treatment of gastrointestinal diseases, improving patient outcomes and quality of life. While robotics have enhanced maneuverability and treatment capability for endoscopists, further developments are needed to address technical limitations and create more sophisticated instruments. Innovative robotic systems are being developed to eventually facilitate minimally invasive robotic surgery across various clinical fields for lower patient risk.
APPLIED SCIENCES-BASEL
(2021)
