Understanding the lncRNA/miRNA-NF kappa B regulatory network in diabetes mellitus: From function to clinical translation

Diabetes mellitus (DM) and its significant ramifications make out one of the primary reasons behind morbidity worldwide. Noncoding RNAs (ncRNAs), such as microRNAs and long noncoding RNAs, are involved in regulating manifold biological processes, including diabetes initiation and progression. One of the established pathways attributed to DM development is NF-kappa B signaling. Neurons, beta cells, adipocytes, and hepatocytes are among the metabolic tissues where NF-kappa B is known to produce a range of inflammatory chemokines and cytokines. The direct or indirect role of ncRNAs such as lncRNAs and miRNAs on the NF-kappa B signaling pathway and DM development has been supported by many studies. As a result, effective diabetes treatment and preventive methods will benefit from a comprehensive examination of the interplay between NF-kappa B and ncRNAs. Herein, we provide a concise overview of the role of NF-kappa B-mediated signaling pathways in diabetes mellitus and its consequences. The reciprocal regulation of ncRNAs and the NF-kappa B signaling pathway in diabetes is then discussed, shedding light on the pathogenesis of the illness and its possible therapeutic interventions.

Automated summary

Diabetes mellitus (DM) and its consequences are one of the leading causes of morbidity worldwide. Noncoding RNAs (ncRNAs), such as microRNAs and long noncoding RNAs, play a role in regulating various biological processes, including the initiation and progression of diabetes. NF-kappa B signaling pathway has been established to be involved in the development of DM, producing inflammatory chemokines and cytokines in metabolic tissues. Many studies have supported the direct or indirect role of ncRNAs, such as lncRNAs and miRNAs, in the NF-kappa B signaling pathway and DM development. Therefore, understanding the interplay between NF-kappa B and ncRNAs is crucial for effective diabetes treatment and preventive methods.